Radiative transitions involving the (2p2)(3 Pe) metastable autodetaching of H(-)

The absorption coefficient for the free-bound transition H (ls) + e(-)+ h omega yields H(-)(2 sq p,(3)P(e)) is calculated (together with the differential emission rate for the inverse process) using ls - 2s - 2p close coupling continuum wave functions and a Hylleraas bound state wave function. A maximum in the absorption and emission spectra is found to occur at a photon wavelength of 1219.5 A, which is 2 A closer to the Lyman alpha line than predicted by the calculations of Drake, and is in closer agreement with the stellar absorption feature identified by Heap and Stecher. The free-bound absorption process appears to be a significant source of continuous ultraviolet opacity

Coexistence of localized and extended states in the Anderson model with long-range hopping

We study states arising from fluctuations in the disorder potential in systems with long-range hopping. Here, contrary to systems with short-range hopping, the optimal fluctuations of disorder responsible for the formation of the states in the gap, are not rendered shallow and long-range when $E$ approaches the band edge ($E\to 0$). Instead, they remain deep and short-range. The corresponding electronic wave functions also remain short-range-localized for all $E<0$. This behavior has striking implications for the structure of the wave functions slightly above $E=0$. By a study of finite systems, we demonstrate that the wave functions $\Psi_E$ transform from a localized to a quasi-localized type upon crossing the $E=0$ level, forming resonances embedded in the $E>0$ continuum. The quasi-localized $\Psi_{E>0}$ consists of a short-range core that is essentially the same as $\Psi_{E=0}$ and a delocalized tail extending to the boundaries of the system. The amplitude of the tail is small, but it decreases with $r$ slowly. Its contribution to the norm of the wave function dominates for sufficiently large system sizes, $L\gg L_c(E)$; such states behave as delocalized ones. In contrast, in small systems, $L\ll L_c(E)$, quasi-localized states are overwhelmingly dominated by the localized cores and are effectively localized.Comment: 18+1 pages, 9+1 figure

Differential carrier lifetime in oxide-confined vertical cavity lasers obtained from electrical impedance measurements

Includes bibliographical references (page 901).Differential carrier lifetime measurements were performed on index-guided oxide-confined vertical cavity surface emitting lasers operating at 980 nm. Lifetimes were extracted from laser impedance measurements at subthreshold currents, with device size as a parameter, using a simple small-signal model. The carrier lifetimes ranged from 21 ns at 9 µA, to about 1 ns at a bias close to threshold. For a 6 × 6 µm2 oxide aperture device the threshold carrier density was nth ~ 2 × 1018cm-3. The effect of carrier diffusion was also considered. An ambipolar diffusion coefficient of D ~ 11 cm2s-1 was obtained.Work at Texas Tech is supported by BMDO (monitored by Lou Lome), DARPA, and the J. F. Maddox Foundation

Anti-inflammatory therapy with nebulised dornase alfa in patients with severe COVID-19 pneumonia A Randomised Clinical Trial

BACKGROUND: SARS-CoV2 infection causes severe, life-threatening pneumonia. Hyper-inflammation, coagulopathy and lymphopenia are associated with pathology and poor outcomes in these patients. Cell-free (cf) DNA is prominent in COVID-19 patients, amplifies inflammation and promotes coagulopathy and immune dysfunction. We hypothesized that cf-DNA clearance by nebulised dornase alfa may reduce inflammation and improve disease outcomes. Here, we evaluated the efficacy of nebulized dornase alfa in patients hospitalised with severe COVID-19 pneumonia. METHODS: In this randomised controlled single-centre phase 2 proof-of-concept trial, we recruited adult patients admitted to hospital that exhibited stable oxygen saturation (≥94%) on supplementary oxygen and a C-reactive protein (CRP) level ≥30mg/L post dexamethasone treatment. Participants were randomized at a 3:1 ratio to receive twice-daily nebulised dornase alfa in addition to best available care (BAC) or BAC alone for seven days or until hospital discharge. A 2:1 ratio of historical controls to treated individuals (HC, 2:1) were included as the primary endpoint comparators. The primary outcome was a reduction in systemic inflammation measured by blood CRP levels over 7 days post-randomisation, or to discharge if sooner. Secondary and exploratory outcomes included time to discharge, time on oxygen, D-dimer levels, lymphocyte counts and levels of circulating cf-DNA. RESULTS: We screened 75 patients and enrolled 39 participants out of which 30 in dornase alfa arm, and 9 in BAC group. We also matched the recruited patients in the treated group (N=30) to historical controls in the BAC group (N=60). For the the primary outcome, 30 patients in the dornase alfa were compared to 69 patients in the BAC group. Dornase alfa treatment reduced CRP by 33% compared to the BAC group at 7-days (P=0.01). The dornase alfa group least squares mean CRP was 23.23 mg/L (95% CI 17.71 to 30.46) and the BAC group 34.82 mg/L (95% CI 28.55 to 42.47). A significant difference was also observed when only randomised participants were compared. Furthermore, compared to the BAC group, the chance of live discharge was increased by 63% in the dornase alfa group (HR 1.63, 95% CI 1.01 to 2.61, P=0.03), lymphocyte counts were improved (least-square mean: 1.08 vs 0.87, P=0.02) and markers of coagulopathy such as D-dimer were diminished (least-square mean: 570.78 vs 1656.96μg/mL, P=0.004). Moreover, the dornase alfa group exhibited lower circulating cf-DNA levels that correlated with CRP changes over the course of treatment. No differences were recorded in the rates and length of stay in the ICU or the time on oxygen between the groups. Dornase alfa was well-tolerated with no serious adverse events reported. CONCLUSION: In this proof-of-concept study in patients with severe COVID-19 pneumonia, treatment with nebulised dornase alfa resulted in a significant reduction in inflammation, markers of immune pathology and time to discharge. The effectiveness of dornase alfa in patients with acute respiratory infection and inflammation should be investigated further in larger trials

Mindfulness-based interventions in epilepsy: a systematic review

Mindfulness based interventions (MBIs) are increasingly used to help patients cope with physical and mental long-term conditions (LTCs). Epilepsy is associated with a range of mental and physical comorbidities that have a detrimental effect on quality of life (QOL), but it is not clear whether MBIs can help. We systematically reviewed the literature to determine the effectiveness of MBIs in people with epilepsy. Medline, Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, Allied and Complimentary Medicine Database, and PsychInfo were searched in March 2016. These databases were searched using a combination of subject headings where available and keywords in the title and abstracts. We also searched the reference lists of related reviews. Study quality was assessed using the Cochrane Collaboration risk of bias tool. Three randomised controlled trials (RCTs) with a total of 231 participants were included. The interventions were tested in the USA (n = 171) and China (Hong Kong) (n = 60). Significant improvements were reported in depression symptoms, quality of life, anxiety, and depression knowledge and skills. Two of the included studies were assessed as being at unclear/high risk of bias - with randomisation and allocation procedures, as well as adverse events and reasons for drop-outs poorly reported. There was no reporting on intervention costs/benefits or how they affected health service utilisation. This systematic review found limited evidence for the effectiveness of MBIs in epilepsy, however preliminary evidence suggests it may lead to some improvement in anxiety, depression and quality of life. Further trials with larger sample sizes, active control groups and longer follow-ups are needed before the evidence for MBIs in epilepsy can be conclusively determined

Plasma structures observed in gas breakdown using a 1.5 MW, 110 GHz pulsed gyrotron

Regular two-dimensional plasma filamentary arrays have been observed in gas breakdown experiments using a pulsed 1.5 MW, 110 GHz gyrotron. The gyrotron Gaussian output beam is focused to an intensity of up to 4 MW/ cm2. The plasma filaments develop in an array with a spacing of about one quarter wavelength, elongated in the electric field direction. The array was imaged using photodiodes, a slow camera, which captures the entire breakdown event, and a fast camera with a 6 ns window. These diagnostics demonstrate the sequential development of the array propagating back toward the source. Gases studied included air, nitrogen, SF6, and helium at various pressures. A discrete plasma array structure is observed at high pressure, while a diffuse plasma is observed at lower pressure. The propagation speed of the ionization front for air and nitrogen at atmospheric pressure for 3 MW/ cm2 was found to be of the order of 10 km/s.open322

Observation of large arrays of plasma filaments in air breakdown by 1.5-MW 110-GHz gyrotron pulses

We report the observation of two-dimensional plasma filamentary arrays with more than 100 elements generated during breakdown of air at atmospheric pressure by a focused Gaussian beam from a 1.5-MW, 110-GHz gyrotron operating in 3-mu s pulses. Each element is a plasma filament elongated in the electric field direction and regularly spaced about one-quarter wavelength apart in the plane perpendicular to the electric field. The development of the array is explained as a result of diffraction of the beam around the filaments, leading to the sequential generation of high intensity spots, at which new filaments are created, about a quarter wavelength upstream from each existing filament. Electromagnetic wave simulations corroborate this explanation and show very good correlation to the observed pattern of filaments.open424

Electron exchange model potential: Application to positronium-helium scattering

The formulation of a suitable nonlocal model potential for electron exchange is presented, checked with electron-hydrogen and electron-helium scattering, and applied to the study of elastic and inelastic scattering and ionization of ortho positronium (Ps) by helium. The elastic scattering and the $n = 2$ excitations of Ps are investigated using a three-Ps-state close-coupling approximation. The higher ($n\ge 3$) excitations and ionization of Ps atom are treated in the framework of Born approximation with present exchange. Calculations are reported of phase shifts, and elastic, Ps-excitation, and total cross sections. The present target elastic total cross section agrees well with experimental results at thermal to medium energies.Comment: 16 latex pages, 7 postscript figure