Ribosomal protein RpL35/uL29 Function in Different Diseases

RpL35/uL29 is member of large subunits. It is shown that RpL35/uL29 participate in different processes in diseases and development. It is shown that RpL35/uL29 is important for ribosome mature. Many authors show that RpL35/uL29 is good indicator for diagnosis. Here we will described role and function of ribosomal protein RpL35/uL29 in different cancer diseases such as colorectal adenocarcinoma and atherosclerosis

Correlations of Lactobacillus in Saliva and OHI, PI, GI and PBI Indices in Pregnant Women

Pregnancy is a completely new physiological condition that stimulates important protective forces of the future mother. The changes that occur in the body of the pregnant woman are hormonal, biochemical, anatomical, and histological which are manifested in the functions of all organs. This study included 66 pregnant women in their first pregnancy living in Pristina or coming from nearby places in Kosovo. It aimed at dermining the Oral Hygiene Index (OHI), Plaque Index (PI), Gingival index (GI) and Index of interdental gingival bleeding (PBI) in pregnant women in the first and third trimester of pregnancy. The amount of Lactobacillus in saliva was determined by the diagnostic test of CRT-bacteria. The results show that OHI value in the third trimester of pregnancy for (p = 0.000) was significantly higher than the value in the first trimester; IDP value in the third trimester of pregnancy for (p=0.000) was significantly higher than the first trimester value; GI value in the third trimester of pregnancy was significantly higher than in the first trimester p 0.05). The correlation between IDP and the value Lactobacillus in pregnant women in the first and third trimesters showed a weak positive value (p> 0.05). The correlation between GI and the value of Lactobacillus in pregnant women in the first and third trimester showed a weak negative insignificant correlation for Spearman Rank Order R = –0.05 and p> 0.05. The results obtained from this study pointed at small differences in the examined parameters which are very important for early detection and timely prevention

Recoding of nonsense mutation as a pharmacological strategy

Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a nonsense-mediated decay (NMD) pathway. The NMD pathway reduces the burden of unproductive protein synthesis by lowering the level of PTC mRNA. There is an endogenous rescue mechanism that produces a full-length protein from a PTC mRNA. Nonsense suppression therapies aim to increase readthrough, suppress NMD, or are a combination of both strategies. Therefore, treatment with translational readthrough-inducing drugs (TRIDs) and NMD inhibitors may increase the effectiveness of PTC suppression. Here we discuss the mechanism of PTC readthrough and the development of novel approaches to PTC suppression. We also discuss the toxicity and bioavailability of therapeutics used to stimulate PTC readthrough

Investigational Anti SARS-COVID 19 Medication

The newly identified severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) that originated in December 2019 in Wuhan, China. By July 2020, the WHO reported over 17 million confirmed cases in over 200 countries around the globe. This review discusses how the COVID-19 pandemic may affect healthy people, structure and replication cycle of SARS- CoV-2; targets and therapeutics SARS- CoV-2 and anti-COVID drugs: strategies and perspectives

Comparative Analysis of Dermatoglyphic Traits in Albanian and Turkish Population Living in Kosovo

The aim of the study was to compare quantitative dermatoglyphic traits of two ethnic groups with different origin and customs, living on the same territory. The dermatoglyphic prints were collected from 800 inhabitants of the Dukagjin valley in southwest Kosovo, of Albanian (400) and Turkish (400) ethnic origin. The quantitative analysis comprised the number of ridges and triradii on the fingers, and the number of ridges in the interdigital areas on the palm (a-b, b-c, and c-d) as well as the size of the atd angle. The statistical analysis showed significant differences between the Albanian and the Turkish males for two fingers and pattern intensity index left, and on palms for a-b rc and c-d rc on both hands and b-c rc on the left hand, and between females for six fingers and almost all palmar traits. Significant inter-population variations were observed for most palmar areas in both sexes but more pronouncedly in females. The differences found between the examined population groups show that admixture between Albanian and Turkish population in Kosovo has been small, and the Turks have retained their ethnic identity for several centuries

Comparative Analysis of Dermatoglyphic Traits in Albanian and Turkish Population Living in Kosovo

The aim of the study was to compare quantitative dermatoglyphic traits of two ethnic groups with different origin and customs, living on the same territory. The dermatoglyphic prints were collected from 800 inhabitants of the Dukagjin valley in southwest Kosovo, of Albanian (400) and Turkish (400) ethnic origin. The quantitative analysis comprised the number of ridges and triradii on the fingers, and the number of ridges in the interdigital areas on the palm (a-b, b-c, and c-d) as well as the size of the atd angle. The statistical analysis showed significant differences between the Albanian and the Turkish males for two fingers and pattern intensity index left, and on palms for a-b rc and c-d rc on both hands and b-c rc on the left hand, and between females for six fingers and almost all palmar traits. Significant inter-population variations were observed for most palmar areas in both sexes but more pronouncedly in females. The differences found between the examined population groups show that admixture between Albanian and Turkish population in Kosovo has been small, and the Turks have retained their ethnic identity for several centuries

Pharmacogenetics- gene and SARS-COVID 19 Medication

An analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes collected from the patients worldwide has identified mutations in the virus that could aid in drug and vaccine development. The researchers found that the virus’s genetic diversity in most countries is similar to what it is globally, suggesting that it was introduced repeatedly by many infected people in each country rather than by a “patient zero.” The genetic analysis found 198 mutations that have occurred more than once. “Mutations in themselves are not a bad thing it is nothing to suggest SARS-CoV-2 is mutating faster or slower than expected. Several factors, including pharmacogenetics, it is possible to contribute to inter-individual variability in drug response. However, till today little is known about the host genetics interaction with infection and COVID-19 progression. To understand the role of host gene, we review the current literature, aggregate readily available genetic resources, and provide some updated analysis relevant to COVID-19 and associated phenotypes

Comparative Analysis of Qualitative Dermatoglyphic Traits of Albanian and Turkish Populations Living in the Area of Dukagjin Valley in Kosovo

Dermatoglyphic prints were collected from 800 inhabitants of Dukagjin valley in Kosovo. The sample consisted of two ethnically different sub-populations who refer themselves as Albanians (N=400) and Turks (N=400). Qualitative analysis of prints concerned the frequency of the patterns on fingers (arch, ulnar and radial loop, whorl, accidental whorl) and on palms (Thenar and I, II, III, and IV interdigital area and the hypothenar, main line index, and the axial »t« triradius position). As was expected due to previous study of quantitative dermatoglyphic traits, in the same population the Albanians and Turks showed to be significantly different in most explored qualitative dermatoglyphic variables. Found differences indicated that the reproductive isolation between the Albanian and Turkish population in Kosovo is substantial, despite the fact that those two ethnic sub-populations live in the close vicinity through several centuries

Comparative Analysis of Qualitative Dermatoglyphic Traits of Albanian and Turkish Populations Living in the Area of Dukagjin Valley in Kosovo

Dermatoglyphic prints were collected from 800 inhabitants of Dukagjin valley in Kosovo. The sample consisted of two ethnically different sub-populations who refer themselves as Albanians (N=400) and Turks (N=400). Qualitative analysis of prints concerned the frequency of the patterns on fingers (arch, ulnar and radial loop, whorl, accidental whorl) and on palms (Thenar and I, II, III, and IV interdigital area and the hypothenar, main line index, and the axial »t« triradius position). As was expected due to previous study of quantitative dermatoglyphic traits, in the same population the Albanians and Turks showed to be significantly different in most explored qualitative dermatoglyphic variables. Found differences indicated that the reproductive isolation between the Albanian and Turkish population in Kosovo is substantial, despite the fact that those two ethnic sub-populations live in the close vicinity through several centuries

Anti-SARS-coronavirus treatment based on molecular interaction

SARS-CoV-2 belongs the family betacoronavirus in Coronoviridae; it is known to have single strand RNA which is enveloped. The first case is reported late2019 in China. From there it is circulate around the world, causing the COVID-19 pandemic situation with higher fatality rates. At the beginner of April 2021 SARS-CoV-2 has infected more than 130 million people and led to 2.84 million death. There are several strategies for cure of SARS-CoV-2 infection, to date the number of drugs who are used for treatment is increased depends of these drugs are used alone or in combination form. FDA has approved remedesivir who have the ability to neutralized antibodies, although clinical effects were controversial. Here we discuss for development of new strategies for therapeutic reason in patients infected by SARS-CoV-2