3 research outputs found
Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid
904-908Platelets aggregation around migrating tumor
cells offers protection against the cytotoxic activity of the natural killers
cells (NKC). The ascorbic acid in 3X10-3Μ
concentration completely inhibited platelet aggregation, decreased thromboxane
B2 levels, and inhibited the expression of platelet membranic
receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC
cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells
ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of
ascorbic acid in increasing the susceptibility of tumor cells to NKC; the
ascorbic acid could be used as part of a multidrug therapy to treat diseases
which up to now have been treated only through chemotherapy