Plasma neutrophil gelatinase-associated lipocalin levels and the hemogram levels and their relationship to disease severity in OCD

Objective: The release of neutrophil gelatinase-associated lipocalin (NGAL), involved with immunity regulation, is a neuromediators. The number of studies related to disease-hemogram in Obsessive Compulsive Disorder (OCD) is low. The aim of our study was to measure the blood NGAL levels and hemogram results in first diagnosis of OCD and to evaluate the relationship between the findings and disease severity. Methods: A total of 28,050 patients, who were presented to psychiatry outpatient clinic between January 2018 and January 2020 were evaluated. Thirty-two patients, for who were diagnosed first-episode OCD and agreed to participate the study were examined with using the Yale Brown Obsession Compulsion Scale (Y-BOCS), to measure the peripheral blood NGAL levels and hemogram results, and related to immune regulation the total leukocyte counts and neutrophil granulocyte percent-age (NEU%); and the C reactive protein (CRP) levels were recorded. Results: In the comparison of the first-episode OCD patients, a significant difference was found between the NEU% and CRP values while was not found between the blood NGAL levels. Although there was no significant difference between the Y-BOCS scores and blood NGAL levels, the Y-BOCS scores increased as the blood hemoglobin and hematocrit values decreased. Conclusion: This is the first study on this topic in the literature, indicated that although there was an increase in some inflammatory mediators in first-episode OCD patients, there was no significant increase between plasma NGAL levels and OCD severity; and that increasing OCD severity did have an effect on blood hemoglobin and hematocrit levels

Evaluation of sleep-wakefulness disorders in healthcare professionals working at a university hospital during COVID-19

BACKGROUND: The COVID-19 pandemic has impaired the sleep-wakefulness cycle especially of healthcare professionals (HP). Sleep is affected by many factors and preventable risk factors protect HP from sleep disorders. To evaluate sleep quality and sleep disorders in HP working to gain insight risk factors and to raise awareness about working risk groups. MATERIAL AND METHODS: The study population consisted of a total of 1190 HP employed at a hospital during the COVID-19 pandemic. From this population, a sample of 110 HP was selected based on reported only complaints of sleep. A sociodemographic data form and subjective sleep-wakefulness scales were applied. Sleep disorder was evaluated according to the ICSD-3. RESULTS: Most of the participants were female. It was observed that 67.3%of the HP had disturbed sleep quality, and that nurses and medical secretaries had more complaints compared to doctors. Insomnia disorders was the most common disorder among the participants. Cases of insomnia disorders were found to be 15.477 times higher among those who had a history of mental disorders in their families, smoking was shown to have the most negative effect on biological rhythm, and married people experienced more sleepiness during the day. CONCLUSIONS During the COVID-19 pandemic, ancillary health staff is at greater risk of experiencing deterioration of sleep quality and insomnia disorders. Female, being married, cigarette smoking, and family history of psychiatric disorders were correlated with the development of sleep complaints

FALLS AND AWARENESS ABOUT FALLS IN ELDERLY AND DEFINING THEIR RELATIONS WITH QUALITY OF LIFE

Uner, Sarp/0000-0002-9880-8811; Telatar, Gokhan/0000-0002-3261-3464; Bicer, Burcu Kucuk/0000-0002-5615-264XWOS: 000446617400606[No abstract available