Conceitos Atuais No Tratamento Das Ataxias Hereditárias

Hereditary ataxias (HA) represents an extensive group of clinically and genetically heterogeneous neurodegenerative diseases, characterized by progressive ataxia combined with extra-cerebellar and multi-systemic involvements, including peripheral neuropathy, pyramidal signs, movement disorders, seizures, and cognitive dysfunction. There is no effective treatment for HA, and management remains supportive and symptomatic. In this review, we will focus on the symptomatic treatment of the main autosomal recessive ataxias, autosomal dominant ataxias, X-linked cerebellar ataxias and mitochondrial ataxias. We describe management for different clinical symptoms, mechanismbased approaches, rehabilitation therapy, disease modifying therapy, future clinical trials and perspectives, genetic counseling and preimplantation genetic diagnosis. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.74324425

Derek Denny-brown: O Homem Por Detrás Dos Gânglios

The authors present an historical review about the main contributions of Professor Derek Denny-Brown to neurology. Some of his achievements include the first description of sensory neuronopathies, and some of the essential textbooks on the function and anatomy of the basal ganglia. In 2016, on the 35th anniversary of his death, modern neurologists are still strongly influenced by his legacy. © 2017, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.75212712

"high Doses Of Riboflavin And The Elimination Of Dietary Red Meat Promote The Recovery Of Some Motor Functions In Parkinson's Disease Patients. C.g. Coimbra And V.b.c. Junqueira. Brazilian Journal Of Medical And Biological Research, 36: 1409-1417, 2003"

[No abstract available]37912971299Coimbra, C.G., Junqueira, V.B.C., High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients (2003) Brazilian Journal of Medical and Biological Research, 36, pp. 1409-1417Pare, S., Burr, S.I., Ross, S.E., Effect of day-time protein restriction on nutrient intakes of free-living Parkinson's disease patients (1992) American Journal of Clinical Nutrition, 55, pp. 701-707Simon, N., Gantcheva, R., Bruguerolle, B., Viallet, F., The effects of a normal protein diet on levodopa plasma kinetics in advanced Parkinson's disease (2004) Parkinsonism and Related Disorders, 10, pp. 137-142Fahn, S., Elton, R.L., Unified Parkinson's Disease Rating Scale (1987) Recent Developments in Parkinson's Disease, 2, pp. 153-164. , Members of the UPDRS Development Committee Fahn S, Marsden CD, Calne DB & Goldstein M (Editors), MacMillan Health Care Information, Florham Park, NJ, USABaldereschi, M., DiCarlo, A., Vanni, P., Ghetti, A., Carbonin, P., Amaducci, L., Inzitani, D., Italian longitudinal study on aging working group. Lifestyle related risk factors for Parkinson's disease: A populational study (2003) Acta Neurologica Scandinavica, 108, pp. 239-244Tsai, C.H., Lo, S.K., See, L.C., Chen, H.Z., Chen, R.S., Weng, Y.H., Chang, F.C., Lu, C.S., Environmental risk factors of young onset Parkinson's disease (2002) Clinical Neurology and Neurosurgery, 104, pp. 328-333Tanner, C.M., Epidemiological clues to the cause of Parkinson's disease (1994) Movement Disorders 3, pp. 124-146. , Marsden CD & Fahn S (Editors) Butterworth-Heinemann, Oxford, UKGolbe, L.I., Farrel, T.M., Davis, P.H., Case-control study of early life dietary factors in Parkinson's disease (1988) Archives of Neurology, 45, pp. 350-353Abbot, R.D., Ross, G.W., White, C.R., Sanderson, W.T., Burchfiel, C.M., Kashon, M., Sharp, D.S., Petrovitch, H., Environment, lifestyle, and physical precursors of clinical Parkinson's disease: Recent findings from the Honolulu-Asia aging study (2003) Journal of Neurology, 250 (SUPPL. 3), pp. III30-III3

Frequency of obsessive and compulsive symptoms in patients with blepharospasm and hemifacial spasm

BACKGROND: Blepharospasm (BS) is a form of central focal dystonia recently associated with psychiatric disorders, particularly obsessive and compulsive symptoms. Hemifacial spasm (HFS) represents a focal myoclonus with peripheral origin in the facial nerve. OBJECTIVE: To determine the frequency of obsessive and compulsive symptoms in patients with BS in comparison with patients with HFS. METHODS: 30 patients from each group (BS and HFS) followed by the botulinum toxin clinic at the HC-UFPR were evaluated using a structured interview based on the DSM-IV criteria and the Yale-Brown scale. RESULTS: were compared by the mean two-tailed t test. RESULTS: We found obsessive or compulsive symptoms in 20 (66.6%) patients with BE and 21 (70%) with HFS. Yale-Brown scale scores for each group were higher among BS patients; however, diferences were not statisticaly significant. CONCLUSION: Our study did not show a significant diference in the comparison of the prevalence of obsessive and compulsive symptoms among patients with BS and HFS.FUNDAMENTOS: Blefaroespasmo (BE) é uma forma de distonia focal central recentemente relacionada a desordens psiquiátricas, particularmente sintomas obsessivos e compulsivos. Espasmo hemifacial (EHF) representa uma forma de mioclonia com origem periférica, no nervo facial. OBJETIVO: Determinar a frequência de sintomas obsessivos e compulsivos em pacientes com BE em comparação com pacientes com EHF. MÉTODO: Foram avaliados 30 pacientes de cada grupo acompanhados no ambulatório de toxina botulínica do HC-UFPR, através de entrevista estruturada baseada nos critérios do DSM-IV e pela escala de Yale-Brown. Os resultados foram comparados pela média do teste de t de Student bicaudal. RESULTADOS: Observaram-se sintomas obsessivos ou compulsivos em 20 (66,6%) pacientes com BE e 21 (70%) pacientes com EHF. Os escores da escala de Yale-Brown em cada grupo foram maiores entre aqueles com BE, porém, as diferenças não foram estatisticamente significativas. CONCLUSÃO: Nosso estudo não evidenciou diferença significativa na comparação de prevalência de sintomas obsessivos e compulsivos entre pacientes com BE e EHF

The G209a Mutation In The α-synuclein Gene In Brazilian Families With Parkinson's Disease

A missense G209A mutation of the alpha-synuclein gene was recently described in a large Contursi kindred with Parkinson's disease (PD). The objective of this study is to determine if the mutation G209A of the alpha-synuclein gene was present in 10 Brazilian families with PD. PD patients were recruited from movement disorders clinics of Brazil. A family history with two or more affected in relatives was the inclusion criterion for this study. The alpha-synuclein G209A mutation assay was made using polymerase chain reaction and the restriction enzyme Tsp451. Ten patients from 10 unrelated families were studied. The mean age of PD onset was 42.7 years old. We did not find the G209A mutation in our 10 families with PD. Our results suggest that alpha-synuclein mutation G209A is uncommon in Brazilian PD families.593 B722724Polymeropoulos, M.H., Autosomal dominant Parkinson's disease and alpha-synuclein (1998) Ann Neurol, 44 (1 SUPPL.), pp. 63-64Polymeropoulos, M.H., Levadan, C., Leroy, E., Mutation in the alpha-synuclein gene identified in families with Parkinson's disease (1997) Science, 276, pp. 2045-2047Krüger, R., Kühn, W., Muller, T., Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease (1998) Nat Genet, 18, pp. 106-108Chan, P., Tanner, C.M., Jiang, X., Langsten, J.W., Failure to find the alpha-synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease (1998) Neurology, 50, pp. 513-514Wang, W.W., Khajavi, M., Patel, B.J., Beach, J., Jankovic, J., Ashizawa, T., The G209A mutation in the α-synuclein gene is not detected in familial cases of Parkinson disease in non-Greek and/or Italian populations (1998) Arch Neurol, 55, pp. 1521-1523Vaughan, Jr., Durr, A., Tassin, J., Bereznai, B., Gasser, T., Bonifati, V., The a-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases (1998) Ann Neurol, 44, pp. 270-273Chan, D.K.Y., Mellich, G., Cai, H., The α-synuclein gene and Parkinson disease in a Chinese population (2000) Arch Neurol, 57, pp. 501-503Gasser, T., Müller-Myhsok, B., Wszolek, Z.K., A susceptibility locus for Parkinson's disease maps to chromosome 2p13 (1998) Nat Genet, 18, pp. 262-265Farrer, M., Gwinn-Hardy, K., Muenter, M., A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor (1999) Hum Mol Genet, 8, pp. 81-85Leroy, E., Boyer, R., Auburger, G., The ubiquitin pathway in Parkinson's disease (1998) Nature, 395, pp. 451-452Kitada, T., Askawa, S., Hattori, N., Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism (1998) Nature, 392, pp. 605-608Gasser, T., Genetics of Parkinson's disease (1998) Ann Neurol, 44 (1 SUPPL.), pp. 53-57Golbe, L.I., Di Iorio, G., Sanges, G., Lazzarini, A.M., LaSala, S., Bonavita, V., Clinical genetic analysis of Parkinson's disease in the Contursi kindred (1996) Ann Neurol, 40, pp. 767-775Gasser, T., Müller-Myhsok, B., Wszolek, Z.K., Genetic complexity and Parkinson's disease (1997) Science, 277, pp. 388-389Bennet, P., Nicholl, D.J., Absence of G209A mutation in alpha-synuclein gene in British families with Parkinson's disease (1998) Neurology, 50, p. 1183Ho, S.L., Kung, M.H.W., G209A mutation in the a-synuclein gene is rare and not associated with sporadic Parkinson's disease (1998) Mov Disord, 13, pp. 970-971Parsian, A., Racette, B., Zhang, Z.H., Mutation, sequence, analysis, and association of a-synuclein in Parkinson's disease (1998) Neurology, 51, pp. 1757-1759Waner, T.T., Schapira, A.H.V., The role of the a-synuclein gene mutation in patients with sporadic Parkinson's disease in the United Kingdom (1998) J Neurol Neurosurg Psychiatry, 65, pp. 378-379Farrer, M., Wavrant-De Vrieze, F., Crook, R., Low frequency of a-synuclein mutations in familial Parkinson's disease (1998) Ann Neurol, 43, pp. 394-397Vaughan, J., Farrer, M.J., Wszolek, Z.K., Sequencing of the alpha-synuclein gene in a large series of case of familial Parkinson's disease fails to reveal any further mutations (1998) Hum Mol Genet, 7, pp. 751-753Lücking, C.B., Dürr, A., Bonifati, V., Association between early-onset Parkinson's disease and mutations in the parkin gene (2000) N Engl J Med, 342, pp. 1560-156