Static Monopoles and Their Anti-Configurations

Recently, we have reported on the existence of some monopoles, multimonopole, and antimonopoles configurations. In this paper we would like to present more monopoles, multimonopole, and antimonopoles configurations of the magnetic ansatz of Ref.\cite{kn:9} when the parameters $p$ and $b$ of the solutions takes different serial values. These exact solutions are a different kind of BPS solution. They satisfy the first order Bogomol'nyi equation but possess infinite energy. They can have radial, axial, or rotational symmetry about the z-axis. We classified these serial solutions as (i) the multimonopole at the origin; (ii) the finitely separated 1-monopoles; (iii) the screening solutions of multimonopole and (iv) the axially symmetric monopole solutions. We also give a construction of their anti-configurations with all the magnetic charges of poles in the configurations reversed. Half-integer topological magnetic charge multimonopole also exist in some of these series of solutions.Comment: 20 pages with 4 figure

Overcoming data scarcity of Twitter: using tweets as bootstrap with application to autism-related topic content analysis

Notwithstanding recent work which has demonstrated the potential of using Twitter messages for content-specific data mining and analysis, the depth of such analysis is inherently limited by the scarcity of data imposed by the 140 character tweet limit. In this paper we describe a novel approach for targeted knowledge exploration which uses tweet content analysis as a preliminary step. This step is used to bootstrap more sophisticated data collection from directly related but much richer content sources. In particular we demonstrate that valuable information can be collected by following URLs included in tweets. We automatically extract content from the corresponding web pages and treating each web page as a document linked to the original tweet show how a temporal topic model based on a hierarchical Dirichlet process can be used to track the evolution of a complex topic structure of a Twitter community. Using autism-related tweets we demonstrate that our method is capable of capturing a much more meaningful picture of information exchange than user-chosen hashtags.Comment: IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, 201

Research Article Analysis of Worst-month Relationship with Annual Rain Attenuation in Malaysia

Abstract: The main of this study is to study effect of rain attenuation during the annual and worst month towards communication link especially in the region where heavy rain is a main factor to signal degeration at high frequencies above 10 GHz. Spectral congestion due to the high demand in satellite communication has enforced the development of the conventional frequency bands. Lower frequency band have shifted to higher frequency band such as microwave frequency in order to provide higher data rates as well as wider bandwidths. However, rain fade has become the major hindrance which could cause severe perturbation towards wireless communication tools and satellite communications. Therefore, in this study, analysis of 1 year rain attenuation measurement was done, in order to observe the relationship between the average worst month statistics with the average annual distribution. The result obtained was found to be large different with the one proposed by ITU, hence for better accuracy, the values of Q 1 and β was modified to be adapted in Malaysia

Activation of the HTLV-I Long Terminal Repeat by the Hepatitis B Virus X Protein

AbstractThe human T-cell leukemia virus type I (HTLV-I) Tax protein and the hepatitis B virus (HBV) X protein have each been shown to activate transcription of their respective viral promoters as well as a subset of cellular gene promoters. Here we show that the HTLV-I long terminal repeat (LTR) is responsive to HBV X transactivation. Maximum levels of X-mediated transactivation of the LTR were 8-fold. An X-responsive-region (XRR) of the LTR is located between nucleotides −355 and −276 and contains an AP-2 binding site, a previously recognized X-responsive element. We demonstrated that Tax and X synergize to activate transcription from the HTLV-I LTR, although the AP-2 binding site was not required for this synergy. These results raise the possibility that the HBV X protein may affect the level of HTLV-I gene expression in co-infected individuals

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Purpose The immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achievinghigh-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aimofthis study was to evaluate metastatic melanoma survivors in terms of health-related quality of life (HRQoL), immune-relatedadverse events (irAEs) and exposure to immunosuppressive agents in a large single centre in the UK.Methods We defined the survivor population as patients with a diagnosis of metastatic melanoma who achieved a durableresponse to an ICI and had been followed-up for a minimum of 12 months from initiation of ICI without disease progression.HRQoL was assessed using SF-36. Electronic health records were accessed to collect data on demographics, treatments, irAEsand survival. HRQoL data was compared with two norm-based datasets.Results Eighty-four metastatic melanoma survivors were eligible and 87% (N = 73) completed the SF-36. ICI-related toxicity ofany grade occurred in 92%of patients and 43%had experienced a grade 3 or 4 toxicity. Almost half (49%) of the patients requiredsteroids for the treatment of ICI-related toxicity, whilst 14% required treatment with an immunosuppressive agent beyondsteroids.Melanoma survivors had statistically significant lower HRQoL scores with regard to physical, social and physical rolefunctioning and general health compared with the normative population. There was a trend towards inferior scores in patientswith previous exposure to ipilimumab compared with those never exposed to ipilimumab.Conclusions Our results show that metastatic melanoma survivors have potentially experienced significant ICI-related toxicityand experience significant impairments in specific HRQoL domains. Future service planning is required to meet this population’sunique survivorship needs.Peer reviewe

Discovering transcriptional modules by Bayesian data integration

Motivation: We present a method for directly inferring transcriptional modules (TMs) by integrating gene expression and transcription factor binding (ChIP-chip) data. Our model extends a hierarchical Dirichlet process mixture model to allow data fusion on a gene-by-gene basis. This encodes the intuition that co-expression and co-regulation are not necessarily equivalent and hence we do not expect all genes to group similarly in both datasets. In particular, it allows us to identify the subset of genes that share the same structure of transcriptional modules in both datasets. Results: We find that by working on a gene-by-gene basis, our model is able to extract clusters with greater functional coherence than existing methods. By combining gene expression and transcription factor binding (ChIP-chip) data in this way, we are better able to determine the groups of genes that are most likely to represent underlying TMs

Three-phase series resonant DC-DC boost converter with double LLC resonant tanks and variable frequency control

This paper proposes a three-phase inverter combined with two LLC resonant tanks series resonant DC-DC boost converter with variable frequency control. The three-phase inverter side of the proposed circuit is connected to identical two-level LLC tanks to ensure balanced resonant currents. The proposed converter requires less switching devices and transformers as compared to the conventional interleaved LLC resonant converter, which competitively offers higher efficiency and reduced size and cost. Furthermore, the proposed converter works above the resonant frequency to achieve zero voltage switching (ZVS) for the entire operating frequency range {(42.5kHz < }{f}{s}{ < 50kHz)} for all switches. Variable frequency controller is considered in order to obtain better stability for diverse loads. Therefore, the proposed converter will have the ability to respond to the load changes by varying the switching frequency to the value that fulfils the requirement. In order to verify the improvement of the proposed converter, the converter performance is compared to conventional interleaved LLC resonant converter. The theoretical outcomes are confirmed through simulation studies using MATLAB/SIMULINK and validated experimentally using a laboratory prototype. Selected results are presented to verify the effectiveness of the proposed converter

Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study

This study aimed to evaluate the efficacy of 3 mouthwashes in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the saliva of coronavirus disease 2019 (COVID-19) patients at 30 min, 1, 2 and 3 h after rinsing. This pilot study included 40 admitted COVID-19 positive patients (10 in each group). Saliva samples were collected before rinsing and at 30 min, 1, 2 and 3 h after rinsing with: Group 1-0.2% Chlorhexidine digluconate (CHX); Group 2-1.5% Hydrogen peroxide (H2O2); Group 3-Cetylpyridinium chloride (CPC) or Group 4 (control group)-No rinsing. Viral load analysis of saliva samples was assessed by Reverse Transcription quantitative PCR. Mean log10 viral load at different time points was compared to that at baseline in all groups using a random effects linear regression analysis while for comparison between groups linear regression analysis was used. The results showed that all groups had a significantly reduced mean log10 viral load both at 2 (p = 0.036) and 3 (p = 0.041) hours compared to baseline. However, there was no difference in mean log10 viral load between any of the investigated mouthwashes and the control group (non-rinsing) at the evaluated time points. Although a reduction in the SARS-CoV-2 viral load in the saliva of COVID-19 patients was observed after rinsing with mouthwashes containing 0.2% CHX, 1.5% H2O2, or CPC, the reduction detected was similar to that achieved by the control group at the investigated time points. The findings of this study may suggest that the mechanical action of rinsing/spitting results in reduction of SARS-CoV-2 salivary load