Conceptual definition of a high voltage power supply test facility

NASA Lewis Research Center is presently developing a 60 GHz traveling wave tube for satellite cross-link communications. The operating voltage for this new tube is - 20 kV. There is concern about the high voltage insulation system and NASA is planning a space station high voltage experiment that will demonstrate both the 60 GHz communications and high voltage electronics technology. The experiment interfaces, requirements, conceptual design, technology issues and safety issues are determined. A block diagram of the high voltage power supply test facility was generated. It includes the high voltage power supply, the 60 GHz traveling wave tube, the communications package, the antenna package, a high voltage diagnostics package and a command and data processor system. The interfaces with the space station and the attached payload accommodations equipment were determined. A brief description of the different subsystems and a discussion of the technology development needs are presented

Static Monopoles and Their Anti-Configurations

Recently, we have reported on the existence of some monopoles, multimonopole, and antimonopoles configurations. In this paper we would like to present more monopoles, multimonopole, and antimonopoles configurations of the magnetic ansatz of Ref.\cite{kn:9} when the parameters $p$ and $b$ of the solutions takes different serial values. These exact solutions are a different kind of BPS solution. They satisfy the first order Bogomol'nyi equation but possess infinite energy. They can have radial, axial, or rotational symmetry about the z-axis. We classified these serial solutions as (i) the multimonopole at the origin; (ii) the finitely separated 1-monopoles; (iii) the screening solutions of multimonopole and (iv) the axially symmetric monopole solutions. We also give a construction of their anti-configurations with all the magnetic charges of poles in the configurations reversed. Half-integer topological magnetic charge multimonopole also exist in some of these series of solutions.Comment: 20 pages with 4 figure

Half-Monopole and Multimonopole

We would like to present some exact SU(2) Yang-Mills-Higgs monopole solutions of half-integer topological charge. These solutions can be just an isolated half-monopole or a multimonopole with topological magnetic charge, ${1/2}m$, where $m$ is a natural number. These static monopole solutions satisfy the first order Bogomol'nyi equations. The axially symmetric one-half monopole gauge potentials possess a Dirac-like string singularity along the negative z-axis. The multimonopole gauge potentials are also singular along the z-axis and possess only mirror symmetries.Comment: 12 pages and 4 figures; typos corrected, reference adde

Overcoming data scarcity of Twitter: using tweets as bootstrap with application to autism-related topic content analysis

Notwithstanding recent work which has demonstrated the potential of using Twitter messages for content-specific data mining and analysis, the depth of such analysis is inherently limited by the scarcity of data imposed by the 140 character tweet limit. In this paper we describe a novel approach for targeted knowledge exploration which uses tweet content analysis as a preliminary step. This step is used to bootstrap more sophisticated data collection from directly related but much richer content sources. In particular we demonstrate that valuable information can be collected by following URLs included in tweets. We automatically extract content from the corresponding web pages and treating each web page as a document linked to the original tweet show how a temporal topic model based on a hierarchical Dirichlet process can be used to track the evolution of a complex topic structure of a Twitter community. Using autism-related tweets we demonstrate that our method is capable of capturing a much more meaningful picture of information exchange than user-chosen hashtags.Comment: IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, 201

Real-time information processing of environmental sensor network data using Bayesian Gaussian processes

In this article, we consider the problem faced by a sensor network operator who must infer, in real time, the value of some environmental parameter that is being monitored at discrete points in space and time by a sensor network. We describe a powerful and generic approach built upon an efficient multi-output Gaussian process that facilitates this information acquisition and processing. Our algorithm allows effective inference even with minimal domain knowledge, and we further introduce a formulation of Bayesian Monte Carlo to permit the principled management of the hyperparameters introduced by our flexible models. We demonstrate how our methods can be applied in cases where the data is delayed, intermittently missing, censored, and/or correlated. We validate our approach using data collected from three networks of weather sensors and show that it yields better inference performance than both conventional independent Gaussian processes and the Kalman filter. Finally, we show that our formalism efficiently reuses previous computations by following an online update procedure as new data sequentially arrives, and that this results in a four-fold increase in computational speed in the largest cases considered

Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study

This study aimed to evaluate the efficacy of 3 mouthwashes in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the saliva of coronavirus disease 2019 (COVID-19) patients at 30 min, 1, 2 and 3 h after rinsing. This pilot study included 40 admitted COVID-19 positive patients (10 in each group). Saliva samples were collected before rinsing and at 30 min, 1, 2 and 3 h after rinsing with: Group 1-0.2% Chlorhexidine digluconate (CHX); Group 2-1.5% Hydrogen peroxide (H2O2); Group 3-Cetylpyridinium chloride (CPC) or Group 4 (control group)-No rinsing. Viral load analysis of saliva samples was assessed by Reverse Transcription quantitative PCR. Mean log10 viral load at different time points was compared to that at baseline in all groups using a random effects linear regression analysis while for comparison between groups linear regression analysis was used. The results showed that all groups had a significantly reduced mean log10 viral load both at 2 (p = 0.036) and 3 (p = 0.041) hours compared to baseline. However, there was no difference in mean log10 viral load between any of the investigated mouthwashes and the control group (non-rinsing) at the evaluated time points. Although a reduction in the SARS-CoV-2 viral load in the saliva of COVID-19 patients was observed after rinsing with mouthwashes containing 0.2% CHX, 1.5% H2O2, or CPC, the reduction detected was similar to that achieved by the control group at the investigated time points. The findings of this study may suggest that the mechanical action of rinsing/spitting results in reduction of SARS-CoV-2 salivary load

Identification of MEN1 gene mutations in families with MEN 1 and related disorders

Following identification of the MEN1 gene, we analysed patients from 12 MEN 1 families, 8 sporadic cases of MEN 1, and 13 patients with MEN 1-like symptoms (e.g. cases of familial isolated hyperparathyroidism (FIHPT), familial acromegaly, or atypical MEN 1 cases) for the presence of germline MEN1 mutations. The entire coding region of the MEN1 gene was sequenced, and mutations were detected in 11 MEN 1 families; one sporadic MEN 1 patient, one case of FIHPT and one MEN 1-like case. Constitutional DNA samples from individuals without MEN1 mutations were digested with several restriction enzymes, Southern blotted and probed with MEN1 cDNA to analyse for the presence of larger deletions of the MEN1 gene unable to be detected by PCR. One MEN 1 patient was found to carry such a deletion. This patient was heterozygous for the D418D polymorphism, however sequence analysis of RT-PCR products showed that only the variant allele was transcribed, thus confirming the result obtained by Southern analysis, which indicated loss of a region containing the initiation codon of one allele. © 2000 Cancer Research Campaig

Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study

Abstract This study aimed to evaluate the efficacy of 3 mouthwashes in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the saliva of coronavirus disease 2019 (COVID-19) patients at 30 min, 1, 2 and 3 h after rinsing. This pilot study included 40 admitted COVID-19 positive patients (10 in each group). Saliva samples were collected before rinsing and at 30 min, 1, 2 and 3 h after rinsing with: Group 1—0.2% Chlorhexidine digluconate (CHX); Group 2—1.5% Hydrogen peroxide (H2O2); Group 3—Cetylpyridinium chloride (CPC) or Group 4 (control group)—No rinsing. Viral load analysis of saliva samples was assessed by Reverse Transcription quantitative PCR. Mean log10 viral load at different time points was compared to that at baseline in all groups using a random effects linear regression analysis while for comparison between groups linear regression analysis was used. The results showed that all groups had a significantly reduced mean log10 viral load both at 2 (p = 0.036) and 3 (p = 0.041) hours compared to baseline. However, there was no difference in mean log10 viral load between any of the investigated mouthwashes and the control group (non-rinsing) at the evaluated time points. Although a reduction in the SARS-CoV-2 viral load in the saliva of COVID-19 patients was observed after rinsing with mouthwashes containing 0.2% CHX, 1.5% H2O2, or CPC, the reduction detected was similar to that achieved by the control group at the investigated time points. The findings of this study may suggest that the mechanical action of rinsing/spitting results in reduction of SARS-CoV-2 salivary load