Evaluation of the prognostic utility of the combination of platelet count with mean platelet volume as a prognostic indicator in head and neck cancer.

The combination of platelet count to mean platelet volume (COP-MPV) has been recently reported as a prognostic indicator of oral cavity cancer and other cancer sites. The aim of the present study was to validate the utility of the COP-MPV as a prognostic indicator in all head and neck cancer (HNC) sites. The clinicopathological characteristics of the COP-MPV with HNC were also investigated. This is a retrospective cohort study that recruited consecutively treated patients at a tertiary level academic hospital. Clinicopathological characteristics were recorded, including the COP-MPV scores. Survival was analyzed using Kaplan-Meier analysis, as well as multivariate Cox Proportional Hazards regression. COP-MPV was not associated with the survival outcome in univariate or multivariate analysis. In the multivariate model, tumor differentiation, tumor stage, nodal stage, surgical margins and hemoglobin were revealed to be significantly associated with survival. The results demonstrated that the COP-MPV is not a suitable prognostic factor for HNC

Is human papillomavirus and p16 expression associated with survival outcomes in nasopharyngeal cancer?: A systematic review and meta-analysis

© 2018 Elsevier Inc. Introduction: Human papillomavirus (HPV) is a known prognostic indicator in oropharyngeal cancer. Not much is known about the prognostic role of HPV in Nasopharyngeal cancer (NPC). Here, we performed a systematic review and meta-analysis of the literature to investigate if HPV status was a prognostic factor for NPC. Methods: PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled Hazard Ratios (HR) for Overall Survival (OS). Results: A total of 7 studies from 2014 to 2018, reporting data on 2646 patients (range 43–1328) were included in this meta-analysis. The pooled data showed that HPV/p16 status was not associated with OS in NPC with HR of 0.77 (95% CI: 0.55–1.09, p = 0.14). The test for heterogeneity showed little to no heterogeneity of results (I2 = 4%, p = 0.38). Subgroup analysis showed that in large sample sizes, HPV was significantly associated with survival. Conclusion: Despite the finding in the pooled HR, we could not draw a definitive conclusion as to the prognostic significance of HPV in NPC. Recommendations for future research are given

Neutrophil-to-lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta-analysis

© 2018 Wiley Periodicals, Inc. Background: The purposes of this systematic review and meta-analysis were to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in head and neck cancer. Methods: A systematic review and meta-analysis were done to investigate the role of NLR in overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and progression-free survival (PFS). Results: For qualitative analysis, 33 cohorts with over 10 072 patients were included. For quantitative analysis, 15 studies were included with 5562 patients. The pooled data demonstrated that an elevated NLR significantly predicted poorer OS and DSS. Conclusion: An elevated pretreatment NLR is a prognostic marker for head and neck cancer. It represents a simple and easily obtained marker that could be used to stratify groups of high-risk patients who might benefit from adjuvant therapy

C Programming Mastery- Job Interview Oriented Preparation

<p>C Programming Mastery- Job Interview Oriented Preparation</p&gt

Evaluation of the prognostic utility of the hemoglobin-to-red cell distribution width ratio in head and neck cancer

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Hemoglobin is a known prognostic marker in many cancers, including head and neck cancer (HNC). There is some evidence that the red cell distribution width, which is an index of variation in size of red blood cells (RBCs), might be associated with prognosis as well. Recently, a novel prognostic biomarker has been reported—the ratio of the hemoglobin-to-red cell distribution width (Hb/RDW). Our objective was to evaluate the prognostic utility of the pretreatment Hb/RDW in HNC, controlled with known prognostic indices. Methods: Retrospective cohort study in a tertiary academic hospital setting. Patients diagnosed with HNC treated with curative-intent surgery were eligible. Metastatic disease was excluded. The variables collected were age, sex, BMI, alcohol/tobacco exposure, performance scores, ACE-27, tumor characteristics, adjuvant treatment, and lab values. The primary endpoints were event-free survival (EFS) and overall survival (OS). OS was defined as time from start of treatment to death from any cause, and EFS was defined as time from start of treatment to any progression, recurrence, or death from any cause. Univariate and multivariate survival analysis was performed on the primary endpoints. Results: A total of 205 patients were enrolled from 2010 to 2016. In multivariate analysis, the factors independently associated with EFS were BMI (p = 0.0364), advanced T stage (p = 0.001), and low Hb/RDW ratio (p = 0.017). The factors independently associated with OS were ECOG score (p = 0.042), advanced T stage (p \u3c 0.0001), positive nodes (p = 0.0195), and Hemoglobin (0.0134). Conclusion: A low Hb/RDW ratio was associated with poorer EFS (HR = 2.02, 95% CI 1.13–3.61, p = 0.017), but was not associated with OS. This is the first study reporting the prognostic utility of Hb:RDW in head and neck cancer

A Comprehensive Study on the Recent Progress and Trends in Development of Small Hydropower Projects

In terms of fuel resource, hydropower possesses a prominent advantage over any other large power plants which burn fossil fuels to generate electricity. Moreover, due to the abundance in resource availability (as a domestic source in small streams and rivers), small hydropower (SHP) plants are showing prominence all over the world. SHP plants have led to improved access to electricity usage in under-developed and developing nations, thereby contributing to sustainable development goals and social empowerment. SHP, as a technology, is regarded as the largest density renewable resource with high adaptability, and low investment costs. The primary objective of the paper is to study and analyze recent developments in SHP technologies with reporting statistical figures in terms of installed capacity and MW potential in several parts of the world. Methodologies adopted by researchers to conduct techno-economic analysis of SHP projects are reviewed. Various costs involved in conducting pre-feasibility studies—such as constructing, maintaining, and sustainably operating SHP projects—are studied. The results of the study indicate cost and regulatory issues are the major factors affecting the growth of the small hydropower sector in many nations. Major impediments to construction, development and deployment of SHP projects, mutually existing among the nations worldwide, are also reported. Technical hindrances include non-availability of the grid and very limited accessibility to SHP sites, emissions due to storage of water, disruptive technologies with limited manpower and non-technical hindrances include discouragement from local bodies and groups, lack of suitable and precise pathways to accomplish SHP goals of a nation, lack of incentives for encouraging private players to invest in SHP projects, complex approval processes, and many more

Levelized cost of electricity generation by small hydropower projects under clean development mechanism in India

Abstract Contrary to conventional fossil fuel-based electricity generation technologies, renewable energy centered technologies, specifically small hydropower, release a lesser amount of anthropogenic greenhouse gases but are normally more expensive. A major segment of the capital investment in the current small hydropower scenario accounts for equipment and construction process costs. The construction and cost administration process are generally limited to analysis of the capital cost of civil constructions, electro-mechanical equipment works, neglecting the costs related to operating and maintaining the plant, replacement or refurbishment, certified emission reductions, among others. Contemporary studies indicate that these costs form a substantial fraction of the total capital investment. Consequently, for cost management and investment decision making, small hydropower plant developers are drawing increased attention in recent years towards conducting life cycle costing studies that take into account the ignored costs. In addition, small hydropower plants in developing nations can become more competitive by trading the emission reductions achieved under the provision of the Clean Development Mechanism, an outcome of the Kyoto Protocol proposed at the United Nations Framework Convention on Climate Change. In this paper, a modest attempt has been made to determine the Levelized cost of electricity generation using life cycle costing methodology, which accounts for all the costs over operating lifetime on a range of small hydropower plants and the results are analyzed