Experimental study of intrinsic multiple Andreev reflections effect in GdO(F)FeAs superconductor array junctions

We report the first observation of the intrinsic multiple Andreev reflections effect (IMARE) in S-n-S-...-S-arrays (S = superconductor, n = normal metal) formed by "break-junction" technique in GdO(F)FeAs superconductor (Tc = 48 - 53 K). We show that superconducting gap peculiarities at dI/dV-spectra sharpen dramatically in the arrays as compared with that in the single-contact spectra; this enables to improve significantly accuracy of the bulk superconducting parameters determination. Using IMARE, we determined the large and the small gap values \Delta_L = 11 +- 1.1 meV and \Delta_S = 2.6 +- 0.4 meV. The BCS-ratio 2\Delta_L/kTc^{local} = 5.0 - 5.9 > 3.52 (Tc^{local} is the contact area critical temperature) evidences for a strong electron-boson coupling. The results obtained agree well with our previous data by Andreev spectroscopy for single SnS-contacts.Comment: 6 pages, 6 figure

An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase

Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm

Observation of Multi-Gap Superconductivity in GdO(F)FeAs by Andreev Spectroscopy

We have studied current-voltage characteristics of Andreev contacts in polycrystalline GdO$_{0.88}$F$_{0.12}$FeAs samples with bulk critical temperature ${T_c}$ = (52.5 \pm 1)K using break-junction technique. The data obtained cannot be described within the single-gap approach and suggests the existence of a multi-gap superconductivity in this compound. The large and small superconducting gap values estimated at T = 4.2K are {\Delta}L = 10.5 \pm 2 meV and {\Delta}S = 2.3 \pm 0.4 meV, respectively.Comment: 5 pages, 4 figures, submitted to JETP Letter

Study of the Two-Gap Superconductivity in GdO(F)FeAs by ScS-Andreev Spectroscopy

Current-voltage characteristics and dynamic conductance of the superconductor - constriction - superconductor junctions in GdO(F)FeAs polycrystalline samples with critical temperatures Tc^local = 46 - 53 K were investigated. Two superconducting gaps, the large Delta_L = 10.5 +- 2 meV, and the small one Delta_S = 2.3 +- 0.4 meV were clearly observed at T = 4.2 K. The 2Delta_L/kTc^local = 5.5 +- 1 ratio gives support to the strong coupling mechanism which is responsible for the high Tc value. Temperature dependence of the large gap Delta_L(T) indicates the presence of intrinsic proximity effect (in k-space) between two superconducting condensates.Comment: 7 pages, 6 figures. Submitted to Journal of Physics: Conference Serie

Safety perspectives on presently considered drugs for the treatment of COVID‐19

Intense efforts are underway to evaluate potential therapeutic agents for the treatment of COVID‐19. In order to respond quickly to the crisis, the repurposing of existing drugs is the primary pharmacological strategy. Despite the urgent clinical need for these therapies, it is imperative to consider potential safety issues. This is important due to the harm–benefit ratios that may be encountered when treating COVID‐19, which can depend on the stage of the disease, when therapy is administered and underlying clinical factors in individual patients. Treatments are currently being trialled for a range of scenarios from prophylaxis (where benefit must greatly exceed risk) to severe life‐threatening disease (where a degree of potential risk may be tolerated if it is exceeded by the potential benefit). In this perspective, we have reviewed some of the most widely researched repurposed agents in order to identify potential safety considerations using existing information in the context of COVID‐19