831 research outputs found

    Gender trouble and its impact on fertility intentions

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    It is often an underlying assumption that the new role of women and in general the trend toward a more egalitarian view of the concept of partnership is a main factor behind the low fertility rates in rich countries The aim of this paper is to test the consequences of gender (in)equity on the desire of women and men to have (further) children by using gender inequity as an important category within population science. In our assumptions we want to test whether an unequal distribution of household chores and childcare duties has a negative effect on the desire to have children. Another assumption examines the potential correlation that the perception of (in)equality of women and men in society or the acceptance of government measures to ensure equal rights might have with the desire to have children. The data are derived from the recent Austrian survey Population Policy Acceptance Survey. The assumptions are tested by means of logistic regression analysis. The results show that it is new men who are likely to express a wish for children, rather than those who live in traditional partnership models

    Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1.

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    RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3. RasGAP has been reported to bind to G3BP1 (RasGAP SH3-domain-binding protein 1), a protein regulating mRNA stability and stress granule formation. The region of RasGAP (amino acids 317-326) thought to bind to G3BP1 corresponds exactly to the sequence within fragment N2, a caspase-3-generated fragment of RasGAP, that mediates sensitization of tumor cells to genotoxins. While assessing the contribution of G3BP1 in the anti-cancer function of a cell-permeable peptide containing the 317-326 sequence of RasGAP (TAT-RasGAP₃₁₇₋₃₂₆), we found that, in conditions where G3BP1 and RasGAP bind to known partners, no interaction between G3BP1 and RasGAP could be detected. TAT-RasGAP₃₁₇₋₃₂₆ did not modulate binding of G3BP1 to USP10, stress granule formation or c-myc mRNA levels. Finally, TAT-RasGAP₃₁₇₋₃₂₆ was able to sensitize G3BP1 knock-out cells to cisplatin-induced apoptosis. Collectively these results indicate that G3BP1 and its putative RasGAP binding region have no functional influence on each other. Importantly, our data provide arguments against G3BP1 being a genuine RasGAP-binding partner. Hence, G3BP1-mediated signaling may not involve RasGAP

    Giant Presternal Dermoid Cyst: An Adult Case

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    Epidermal cysts are more common above the shoulder and within the face and scalp. The authors report a case of giant presternal dermoid cyst in a 25 year old man. The case illustrates that dermoid cysts can appear in atypical location. Dermoid cysts should be considered in the differential diagnosis of midsternal lesions regardless of the size and imaging characteristics.Key Words: Dermoid cyst, Presternal chest wall, Thoracic surger

    Giant adrenal pseudocyst, about a new case report

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    Introduction: Adrenal pseudocysts are rare benign lesions. Mostly, these are small lesions discovered incidentally by imaging. The giant forms are rare. Through a new observation, we describe the different epidemiological, clinical, pathological features and treatment of this entity.Observation: A patient of 52 years old, without notable medical history, suffered left flank pain associated with bilious vomiting of 15 days duration. Abdominal examination revealed a voluminous mass at the left hypochondrium. Imaging revealed a huge heterogeneous mass, located between the spleen and kidney, compressing adjacent organs. Given the diagnostic difficulty, a laparotomy was undertaken to excise the mass. Histological examination revealed a giant benign adrenal pseudocyst.Comment: Giant adrenal pseudocysts are very rare. Clinical and radiological signs are not specific. Only pathological study can confirm the diagnosis and exclude malignancy. The treatment is based on surgery for large or symptomatic cysts

    Tuberculose uro-génitale : A propos de 95 cas

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    Objectif: PrĂ©ciser les aspects cliniques, iconographiques et thĂ©rapeutiques de la tuberculose urogĂ©nitale. Patients et mĂ©thodes: D’avril 1992 Ă  avril 2007, 95 patients atteints de tuberculose uro-gĂ©nitale ont Ă©tĂ© vus. Il s’agissait de 53 hommes et 42 femmes ĂągĂ©s de 18 Ă  72 ans. Tous nos malades ont bĂ©nĂ©ficiĂ© d’un interrogatoire, avec recherche des antĂ©cĂ©dents de tuberculose extra urinaire, d’un examen clinique, d’une crĂ©atinĂ©mie, d’une urographie intra veineuse (UIV), d’une Ă©chographie et/ou tomodensitomĂ©trie, de la recherche du bacille de Koch (BK) dans les urines, d’un ECBU, d’une cystoscopie, et d’une analyse histologique des fragments biopsiques et/ou de la piĂšce d’exĂ©rĂšse. RĂ©sultats: Le diagnostic Ă©tait basĂ© sur un faisceau d’arguments cliniques, bactĂ©riologiques et radiologiques. L’irritation vĂ©sicale reprĂ©sentait la manifestation clinique la plus frĂ©quente (51,5%). L’atteinte gĂ©nitale isolĂ©e Ă©tait prĂ©sente chez 17,8% des patients. 16,8% de nos malades avaient une insuffisance rĂ©nale inaugurale (crĂ©atinine moyenne de 24 mg/l). La recherche de BK a Ă©tĂ© rĂ©alisĂ©e chez tous les patients et n’a Ă©tĂ© positive que dans 9,4% des cas. Les anomalies Ă  l’UIV concernaient 86% des malades avec un rein muet dans 42% des cas. On a traitĂ© tous nos patients par une chimiothĂ©rapie antibacillaire associĂ©e Ă  la chirurgie (85,2%) et/ou Ă  des manoeuvres endo-urologiques (20%). Avec un recul moyen de 3 ans (extrĂȘmes allant de 1 Ă  9 ans), la plupart de nos patients ont bien Ă©voluĂ© sous traitement. L’amĂ©lioration clinique a Ă©tĂ© spectaculaire avec disparition des signes cliniques chez 88% des patients. La fonction rĂ©nale a Ă©tĂ© normalisĂ©e chez 70% des cas. Conclusion: La tuberculose reste une maladie grave par son Ă©volution latente et le diagnostic tardif. L’amĂ©lioration de son pronostic passe par la prĂ©vention et par une bonne prise en charge diagnostique et thĂ©rapeutique.Mots clĂ©s : Tuberculose uro-gĂ©nitale, diagnostic, traitemen

    Abord trans-symphysaire des ruptures posttramatiques de l’urĂštre postĂ©rieur chez l’adulte

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    Objectif: Etudier la place de la voie trans-symphysaire dans le traitement des ruptures posttraumatiques de l’urĂštre postĂ©rieur vues tardivement et en Ă©valuer ses rĂ©sultats. Patients et mĂ©thodes: Cinq malades ayant une rupture complĂšte post-traumatique de l’urĂštre postĂ©rieur (> 2,5 cm et/ou Ă©chec d’un traitement antĂ©rieur) ont Ă©tĂ© traitĂ©s dans notre service au stade de stĂ©nose urĂ©trale. Tous les patients ont eu une urĂ©trorraphie termino-terminale par voie trans-symphysaire seule. Une description technique et une Ă©valuation clinique et paraclinique des rĂ©sultats sur le plan mictionnel et sexuel ont Ă©tĂ© rĂ©alisĂ©es dans ce travail. RĂ©sultats: Les rĂ©sultats ont Ă©tĂ© Ă©valuĂ©s avec un suivi mĂ©dian de 19 mois. Aucune complication post-opĂ©ratoire immĂ©diate (saignement, fistule, douleur) n’a Ă©tĂ© rapportĂ©e. Sur le plan mictionnel, on a constatĂ© dans tous les cas une miction satisfaisante, sans troubles de la continence et un cas de dysfonction Ă©rectile amĂ©liorĂ©e par le traitement mĂ©dical. Aucun patient ne s’est plaint de troubles de la statique pelvienne. Conclusion: La voie trans-symphysaire constitue un excellent abord pour le traitement des lĂ©sions complexes de l’urĂštre postĂ©rieur vues tardivement. Cette technique permet d’avoir un abord direct sur l’urĂštre postĂ©rieur et de rĂ©aliser une suture termino-terminale sans tension. Les rĂ©sultats sont satisfaisants et les inconvĂ©nients sont plus thĂ©oriques que rĂ©els.Mots clĂ©s : Rupture de l’urĂštre postĂ©rieur, stĂ©nose de l’urĂštre postĂ©rieur, urĂ©trorraphie, voie transsymphysair

    Emphysematous cystitis and emphysematous pyelitis: A clinically misleading association

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    We present a rare case of emphysematous cystitis associated with an emphysematous pyelonephritis in a diabetic Arab man who was admitted ina confusional state. A 60-year-old man was admitted to the emergency department with confusion and hypogastric mass. The Clinical examinationfound comatose patient with a mass in the tympanic hypogastric percussion. The pelvic computed tomography (CT) demonstrated intramural gas in the urinarytract, which suggested a diagnosis of emphysematous cystitis and emphysematous pyelitis. The treatment was based on an antibiotics  associated with a bladder drainage and diabetes stabilization. The evolution was uneventful. Every diabetic patient with a urinary tract infection who seems to be severely ill should have an abdominal X-ray as a minimal screening tool to detect emphysematous complications. The rarity and the association with an emphysematous pyelitis, which is rarely reported in the literature, are two remarkable characteristics described in this case report

    Invasive group B streptococcal infections in adults, France (2007–2010)

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    AbstractGroup B streptococcus (GBS) has emerged as an important cause of invasive infection in adults. Here, we report the clinical and microbiological characteristics of 401 non-redundant GBS strains causing adult invasive infections collected during a 4-year period (2007–2010). Bacteraemia without focus (43.4%) and bone and joint infections (18.7%) were the main clinical manifestations. The distribution of capsular polysaccharide (CPS) type showed that types Ia, III, and V accounted for 71.8% of all strains. Resistance to erythromycin increased from 20.2% in 2007 to 35.3% in 2010, and was mainly associated with CPS type V harbouring the erm(B) resistant determinant
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