Multivariate Measures of Concordance for Copulas and their Marginals

Building upon earlier work in which axioms were formulated for multivariate measures of concordance, we examine properties of such measures. In particular, we examine the relations between the measure of concordance of an $n$-copula and the measures of concordance of the copula's marginals

Role of Novel Receptor GPR171 in Chemotherapy-Induced Neuropathic Pain

First-line chemotherapies against solid tumors are highly efficacious in reducing the tumor burden, but have many adverse side-effects including nerve damage, leading to chronic pain. Non-addictive, efficacious pain relievers are an area of active interest, and we propose a novel target to address this pressing issue. GPR171 is a G-Protein Coupled Receptor that was recently deorphanized and was identified to be expressed in the brain in regions that regulate reward, anxiety, and pain. Within the pain circuit, it was shown previously that systemic administration of the GPR171 agonist enhances morphine antinociception in acute pain tests. Preliminary data from our lab has shown that GPR171 activation can also alleviate persistent inflammatory pain. However, the role of this receptor has not been investigated in other chronic pain models. Given these findings in acute and inflammatory pain, we hypothesize that GPR171 can reduce neuropathic pain. To test this hypothesis, we investigate the role of GPR171 in chronic neuropathic pain. We tested the efficacy of a GPR171 agonist in a chemotherapy-induced neuropathy mouse model. Neuropathic pain was induced by injecting paclitaxel (16 mg/kg) followed by assessment of mechanical pain thresholds using Von Frey filaments. Our results indicate that the GPR171 agonist can relieve neuropathic pain. In addition, using immunofluorescence we observed that mice with neuropathic pain show a decrease in GPR171 receptors within a key brain region involved in pain modulation, the periaqueductal gray (PAG). Overall, this study proposes that GPR171 may be a novel target for the treatment of neuropathic pain. Presentation Time: Thursday, 1-2 p.m

Fragments of the earliest land plants

The earliest fossil evidence for land plants comes from microscopic dispersed spores. These microfossils are abundant and widely distributed in sediments, and the earliest generally accepted reports are from rocks of mid-Ordovician age (Llanvirn, 475 million years ago). Although distribution, morphology and ultrastructure of the spores indicate that they are derived from terrestrial plants, possibly early relatives of the bryophytes, this interpretation remains controversial as there is little in the way of direct evidence for the parent plants. An additional complicating factor is that there is a significant hiatus between the appearance of the first dispersed spores and fossils of relatively complete land plants (megafossils): spores predate the earliest megafossils (Late Silurian, 425 million year ago) by some 50 million years. Here we report the description of spore-containing plant fragments from Ordovician rocks of Oman. These fossils provide direct evidence for the nature of the spore-producing plants. They confirm that the earliest spores developed in large numbers within sporangia, providing strong evidence that they are the fossilized remains of bona fide land plants. Furthermore, analysis of spore wall ultrastructure supports liverwort affinities

IDENTIFICATION AND CHARACTERIZATION OF THE GLUCAGON-LIKE PEPTIDE-2 HORMONAL SYSTEM IN RUMINANTS

The hormone glucagon-like peptide-2 (GLP-2) is important in the regulation of intestinal growth and blood flow in nonruminant animals. However, no research reports the existence of GLP-2 in ruminants. Therefore, this dissertation examined the existence of GLP-2 and its receptor, their response to physiological stimuli, and its ability to induce gastrointestinal growth and intestinal blood flow in ruminants. Experiments 1 and 2 established the gastrointestinal distribution of mRNA for proglucagon (the GLP-2 precursor) and the GLP-2 receptor. Furthermore, these experiments determined the effects of changing dietary energy intake on plasma GLP-2 concentrations and proglucagon and GLP-2 receptor mRNA expression. Experiment 3 examined the effect of exogenous bovine GLP-2 on splanchnic blood flow, splanchnic nutrient flux, and gastrointestinal growth. This research shows that ruminants possess a functional GLP-2 signaling system that responds to nutrient ingestion. Based on observed receptor distribution and growth changes with GLP-2 treatment, GLP-2 targets the small intestine and does not affect forestomach or large intestinal growth. Increases in ileal proglucagon mRNA expression and plasma GLP-2 with increasing energy intake demonstrate that GLP-2 responds to physiologic changes in nutrient intake and can be relevant to feeding practices. Furthermore, observed increases in small intestinal growth and blood flow with GLP-2 suggest that it could substantially affect the capacity of the gastrointestinal tract for nutrient absorption. Modification of GLP-2 through diet could allow for improvements in nutrient utilization and animal productivity. This research also has important implications for use of GLP-2 for human disease therapy as the observed downregulation in the blood flow response to 10-d GLP-2 administration has never been reported in any species prior to this dissertation. This research systematically characterized and evaluated the potential role of GLP-2 in the control of gastrointestinal growth and splanchnic blood flow in ruminants. While it extends the knowledge of hormonal control of the gastrointestinal tract in ruminants, it also adds crucial information to the larger body of work investigating the actions of GLP- 2. This dissertation research has contributed to the groundwork necessary to enable the use of GLP-2 in improving the health and productivity of a diverse group of mammalian species

Unbuilt Clemson: a story of institutional resilience

Unbuilt Clemson (slated for publication in Spring 2020 by Clemson University Press) is an in-depth excavation—from institutional records, archival evidence, and oral histories—of selected unrealized building projects throughout the history of campus development and planning at Clemson University, with a focus on projects developed to the building design or site plan stage. Six chapters, a dozen case studies, and 50+ illustrations will span the years 1890-2017, documenting how campus planners both shaped and accommodated Clemson’s evolution from an all-male, cadet-corps “agricultural and mechanical” college to a 21st-century, nationally-ranked Carnegie R-1 institution with an international student body and an expanding global network of government, business, and industry partnerships. Telling Clemson’s development history through the lens of unbuilt projects reconstitutes a more complete and inclusive institutional biography, one that acknowledges diverging visions, competing priorities and ideologies, rejected possibilities, winners and losers, even lost opportunities on the part of campus leaders, whether faculty, administrators, or benefactors. Central to our narrative is the school’s accelerating pursuit of a ‘campus master plan’/multi-year ‘strategic plan’ ethos, one progressively in sync with the professionalization of both planning and university administration—first nationally, then regionally—starting in the mid-20th century. At the same time, our account never loses sight of the indelible influence Clemson’s plantation legacy continues to exert on the campus environment, physically and ideologically, and the inherent tension between that legacy and the university’s land-grant, public higher education mandate

A Proposed Guidance Program for the Goliad Colored School in Goliad, Texas

The problem in this study is to determine what happens to the students who withdraw and those who graduate from the Goliad Colored High School. In the light of the findings the writer attempts to make some suggestions for a guidance program. Among the questions to be answered in the attempt to solve the problem are the following: 1. What is the family status of those who withdraw? Of those who graduate? 2. What do the withdrawals and graduates do after leaving school? 3. What are their vocational ambitions? 4. Why have the students withdrawn from the school? 5. How do these groups spend their leisure time? 6. What opportunities exist for the Negroes in Goliad

The Swinburne Intermediate Latitude Pulsar Survey

We have conducted a survey of intermediate Galactic latitudes using the 13-beam 21-cm multibeam receiver of the Parkes 64-m radio telescope. The survey covered the region enclosed by 5 deg < |b| < 15 deg and -100 deg < l < 50 deg with 4,702 processed pointings of 265 s each, for a total of 14.5 days of integration time. Thirteen 2x96-channel filterbanks provided 288 MHz of bandwidth at a centre frequency of 1374 MHz, one-bit sampled every 125 microsec and incurring ~DM/13.4 cm^-3 pc samples of dispersion smearing. The system was sensitive to slow and most millisecond pulsars in the region with flux densities greater than approximately 0.3--1.1 mJy. Offline analysis on the 64-node Swinburne workstation cluster resulted in the detection of 170 pulsars of which 69 were new discoveries. Eight of the new pulsars, by virtue of their small spin periods and period derivatives, may be recycled and have been reported elsewhere. The slow pulsars discovered are typical of those already known in the volume searched, being of intermediate to old age. Several pulsars experience pulse nulling and two display very regular drifting sub-pulses. We discuss the new discoveries and provide timing parameters for the 48 slow pulsars for which we have a phase-connnected solution.Comment: 19 pages, 11 figures, accepted to MNRA

Submergence and uplift associated with the giant 1833 Sumatran subduction earthquake: Evidence from coral microatolls

The giant Sumatran subduction earthquake of 1833 appears as a large emergence event in fossil coral microatolls on the reefs of Sumatra's outer-arc ridge. Stratigraphic analysis of these and living microatolls nearby allow us to estimate that 1833 emergence increased trenchward from about 1 to 2 m. This pattern and magnitude of uplift are consistent with about 13 m of slip on the subduction interface and suggest a magnitude (M_w) of 8.8–9.2 for the earthquake. The fossil microatolls also record rapid submergence in the decades prior to the earthquake, with rates increasing trenchward from 5 to 11 mm/yr. Living microatolls show similar rates and a similar pattern. The fossil microatolls also record at least two less extensive emergence events in the decades prior to 1833. These observations show that coral microatolls can be useful paleoseismic and paleogeodetic instruments in convergent tectonic environments

First impressions: introducing the 'Real Times' third sector case studies

‘Real Times’ is the Third Sector Research Centre’s qualitative longitudinal study of third sector organisations, groups and activities. Over a three year period the study is following the fortunes, strategies, challenges and performance of a diverse set of fifteen ‘core’ case studies of third sector activity, and their relations with a number ‘complementary’ case studies. This report introduces the core case studies through summary sketches, and provides a descriptive account of the research up to the end of the first wave of fieldwork

Grappling with the complexity of the New Zealand Curriculum: Next steps in exploring the NZC in initial teacher education.

Teacher educators in New Zealand are charged with supporting student teachers' understandings of the New Zealand Curriculum document (Ministry of Education, 2007). Integral to this challenge is the need to provide relevant knowledge and understandings that are contextually and pedagogically appropriate (Fullan, 2007; Jasman, 2003). Aspects of the "front end" of the New Zealand Curriculum document such as the vision, principles, values and key competencies along with the learning area statements need to be understood by newly graduated teachers who will be applying this curriculum in their own classrooms. This paper reports on ongoing research investigating and reflecting on student-teacher understandings of these components of the New Zealand curriculum, on completion of three different compulsory papers within the Bachelor of Teaching degree and Graduate Diploma of Teaching (Primary). Implications for pre-service teacher education and for supporters of provisionally registered teachers are considered