Intelligent modelling of bioprocesses: A comparison of structured and unstructured approaches

This contribution moves in the direction of answering some general questions about the most effective and useful ways of modelling bioprocesses. We investigate the characteristics of models that are good at extrapolating. We trained 3 fully predictive models with different representational structures (diff eqns, inheritance of rates, network of reactions) on Saccharopolyspora erythraea shake flask fermentation data using genetic programming. The models were then tested on unseen data outside the range of the training data and the resulting performances compared. It was found that constrained models with mathematical forms analogous to internal mass balancing and stoichiometric were superior to flexible unconstrained models even though no A priori knowledge of this fermentation was used

Drip Paintings and Fractal Analysis

It has been claimed [1-6] that fractal analysis can be applied to unambiguously characterize works of art such as the drip paintings of Jackson Pollock. This academic issue has become of more general interest following the recent discovery of a cache of disputed Pollock paintings. We definitively demonstrate here, by analyzing paintings by Pollock and others, that fractal criteria provide no information about artistic authenticity. This work has also led to two new results in fractal analysis of more general scientific significance. First, the composite of two fractals is not generally scale invariant and exhibits complex multifractal scaling in the small distance asymptotic limit. Second the statistics of box-counting and related staircases provide a new way to characterize geometry and distinguish fractals from Euclidean objects

Identification of the Beutler-Fano formula in eigenphase shifts and eigentime delays near a resonance

Eigenphase shifts and eigentime delays near a resonance for a system of one discrete state and two continua are shown to be functionals of the Beutler- Fano formulas using appropriate dimensionless energy units and line profile indices. Parameters responsible for the avoided crossing of eigenphase shifts and eigentime delays are identified. Similarly, parameters responsible for the eigentime delays due to a frame change are identified. With the help of new parameters, an analogy with the spin model is pursued for the S matrix and time delay matrix. The time delay matrix is shown to comprise three terms, one due to resonance, one due to a avoided crossing interaction, and one due to a frame change. It is found that the squared sum of time delays due to the avoided crossing interaction and frame change is unity.Comment: 17 pages, 3 figures, RevTe

Renormalized Equilibria of a Schloegl Model Lattice Gas

A lattice gas model for Schloegl's second chemical reaction is described and analyzed. Because the lattice gas does not obey a semi-detailed-balance condition, the equilibria are non-Gibbsian. In spite of this, a self-consistent set of equations for the exact homogeneous equilibria are described, using a generalized cluster-expansion scheme. These equations are solved in the two-particle BBGKY approximation, and the results are compared to numerical experiment. It is found that this approximation describes the equilibria far more accurately than the Boltzmann approximation. It is also found, however, that spurious solutions to the equilibrium equations appear which can only be removed by including effects due to three-particle correlations.Comment: 21 pages, REVTe

Quantum Mechanical Carrier of the Imprints of Gravitation

We exhibit a purely quantum mechanical carrier of the imprints of gravitation by identifying for a relativistic system a property which (i) is independent of its mass and (ii) expresses the Poincare invariance of spacetime in the absence of gravitation. This carrier consists of the phase and amplitude correlations of waves in oppositely accelerating frames. These correlations are expressed as a Klein-Gordon-equation-determined vector field whose components are the ``Planckian power'' and the ``r.m.s. thermal fluctuation'' spectra. The imprints themselves are deviations away from this vector field.Comment: 8 pages, RevTex. Html version of this and related papers on accelerated frames available at http://www.math.ohio-state.edu/~gerlac

Karhunen-Loeve eigenvalue problems in cosmology: how should we tackle large data sets?

Since cosmology is no longer "the data-starved science", the problem of how to best analyze large data sets has recently received considerable attention, and Karhunen-Loeve eigenvalue methods have been applied to both galaxy redshift surveys and Cosmic Microwave Background (CMB) maps. We present a comprehensive discussion of methods for estimating cosmological parameters from large data sets, which includes the previously published techniques as special cases. We show that both the problem of estimating several parameters jointly and the problem of not knowing the parameters a priori can be readily solved by adding an extra singular value decomposition step. It has recently been argued that the information content in a sky map from a next generation CMB satellite is sufficient to measure key cosmological parameters (h, Omega, Lambda, etc) to an accuracy of a few percent or better - in principle. In practice, the data set is so large that both a brute force likelihood analysis and a direct expansion in signal-to-noise eigenmodes will be computationally unfeasible. We argue that it is likely that a Karhunen-Loeve approach can nonetheless measure the parameters with close to maximal accuracy, if preceded by an appropriate form of quadratic "pre-compression". We also discuss practical issues regarding parameter estimation from present and future galaxy redshift surveys, and illustrate this with a generalized eigenmode analysis of the IRAS 1.2 Jy survey optimized for measuring beta=Omega^{0.6}/b using redshift space distortions.Comment: 15 pages, with 5 figures included. Substantially expanded with worked COBE examples for e.g. the multiparameter case. Available from http://www.sns.ias.edu/~max/karhunen.html (faster from the US), from http://www.mpa-garching.mpg.de/~max/karhunen.html (faster from Europe) or from [email protected]

Summary of the Very Large Hadron Collider Physics and Detector Workshop

One of the options for an accelerator beyond the LHC is a hadron collider with higher energy. Work is going on to explore accelerator technologies that would make such a machine feasible. This workshop concentrated on the physics and detector issues associated with a hadron collider with an energy in the center of mass of the order of 100 to 200 TeV