Knowledge management: Using a knowledge requirements framework to enhance UK health sector supply chains

The gaps of mismatch both knowledge and understanding of beneficiaries and solution providers at the initial stage of developing projects have led to the failures of many projects including supply chains (SC) and related information technology systems (ITS) projects (Lyytinen and Hirschheim, 1987) . The aims of this paper are first, to address theoretical framework by bridging the gaps of different types of knowledge. Second, to establishing business requirements and the flow of information in supply chains between beneficiaries and solution providers in the long and complicated supply chains of the UK’s Health Sector. On the basis of brief introduction to knowledge, knowledge management and supply chain, the paper presents a practical framework that has been developed through critical and relevant literatures in the above three subject areas. Techniques and Tools stem from both management science and information systems were used to provide a possible solution for the problem in bridging the gaps of mismatch knowledge and understanding at the initial stage of identifying requirements in projects through knowledge sharing and transfer

Taking Tasers Seriously: The Need for Better Regulation of Stun Guns in New York

This report analyzes 851 Taser incident reports from eight police departments across the state as well as 10 departments' policies and guidelines for using the weapons, which deliver up to 50,000 volts of electricity and have caused the deaths of more than a dozen New Yorkers in recent years. The report concludes that police officers throughout New York State are consistently misusing and overusing Tasers

Continuous Nowhere Differentiable Functions

In this presentation we study functions that are continuous everywhere on their domain but differentiable nowhere.  One such function is the function whose graph is called the Kiesswetter curve.  First we construct the curve and the piece-wise function that represents that curve.  We prove several key properties of the function that gives us insight to why this function is continuous on the unit interval.  We then prove the continuity and nondifferentiability of the function

Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH

Background Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug resistance and co-infection with HIV/AIDS. Tuberculosis control requires new drugs that act at novel drug targets to help combat resistant forms of Mycobacterium tuberculosis and reduce treatment duration. Methodology/Principal Findings Our approach was to modify the naturally occurring and synthetically challenging antibiotic thiolactomycin (TLM) to the more tractable 2-aminothiazole-4-carboxylate scaffold to generate compounds that mimic TLM's novel mode of action. We report here the identification of a series of compounds possessing excellent activity against M. tuberculosis H37Rv and, dissociatively, against the β-ketoacyl synthase enzyme mtFabH which is targeted by TLM. Specifically, methyl 2-amino-5-benzylthiazole-4-carboxylate was found to inhibit M. tuberculosis H37Rv with an MIC of 0.06 µg/ml (240 nM), but showed no activity against mtFabH, whereas methyl 2-(2-bromoacetamido)-5-(3-chlorophenyl)t​hiazole-4-carboxylateinhibited mtFabH with an IC50 of 0.95±0.05 µg/ml (2.43±0.13 µM) but was not active against the whole cell organism. Conclusions/Significance These findings clearly identify the 2-aminothiazole-4-carboxylate scaffold as a promising new template towards the discovery of a new class of anti-tubercular agents

Multiple directorships, family ownership and the board nomination committee: International evidence from the GCC

In this paper, we investigate the association between outside board directorships and family ownership concentration. Using a sample of 1091 firm-year observations of non-financial publicly listed firms from Gulf Cooperation Countries (GCC) during the 2005 to 2013 period, we find a positive association between family ownership and the number of outside directorships held by board members. This finding is consistent with the notion that family ownership reduces a board's monitoring capabilities. We also test whether the recent corporate governance reforms in GCC, which were designed to protect investors and minority shareholders, affect firms' incentives to establish a board nomination committee (NC). We find the existence of a board NC and the quality and characteristics of NC membership act to suppress the positive association between outside directorships and family ownership. Our results are robust to the use of alternative measures of outside directorships and family ownership and models that test for endogeneity. Overall, our results suggest that the institutional specificities of emerging economies such as those in the GCC can sustain high levels of multiple directorships, which could impair the quality of corporate governance

Spectropolarimetric Variability and Co-Rotating Structure in HD 92207

We report on low resolution (R~3000) spectropolarimetry of the A0 supergiant star HD 92207. This star is well-known for significant spectral variability. The source was observed on seven different nights spanning approximately 3 months in time. With a rotation period of approximately 1 year, our data covers approximately a quarter of the star's rotational phase. Variability in the continuum polarization level is observed over this period of time. The polarization across the Halpha line on any given night is typically different from the degree and position angle of the polarization in the continuum. Interestingly, Hbeta is not in emission and does not show polarimetric variability. We associate the changes at Halpha as arising in the wind, which is in accord with the observed changes in the profile shape and equivalent width of Halpha along with the polarimetric variability. For the continuum polarization, we explore a spiral shaped wind density enhancement in the equatorial plane of the star, in keeping with the suggestion of Kaufer etal (1997). Variable polarization signatures across Halpha are too complex to be explained by this simple model and will require a more intensive polarimetric follow-up study to interpret properly.Comment: to appear in A