Barriers to the use of a diagnostic oral microbiology laboratory by general dental practitioners

OBJECTIVE: To identify barriers on the use of diagnostic microbiology facilities in general dental practice. DESIGN: A cross-sectional survey using a postal questionnaire. SETTING: Primary/secondary care interface between the diagnostic oral microbiology laboratory, University of Glasgow Dental Hospital and School, Glasgow and dental practitioners within the surrounding health boards, 1998. SUBJECTS: All GDPs (797) within Argyll and Clyde, Ayrshire and Arran, Lanarkshire and Greater Glasgow Health Boards. MAIN OUTCOME MEASURES: The responses were expressed as both absolute and relative frequencies. RESULTS: Responses were received from 430 (55%). The most frequent reason for failure to use the service was lack of information, with more than half of the respondents claiming to be unaware of the facility. Lack of request forms and sampling equipment were also viewed as barriers to using the service. CONCLUSIONS: The laboratory is failing to successfully communicate its role in addressing the growing burden of antibiotic resistance in the community and must be more proactive in encouraging appropriate use and increasing accessibility of the service to GDPs

Assessing the reliability and validity of television and game violence exposure measures

This study evaluated whether common self-report measures of television and game violence exposure represent reliable and valid measurement tools. Three self-report measures—direct estimates, user-rated favorites, and agency-rated favorites—were assessed in terms of test-retest reliability, criterion validity (their relationship with coded media diaries), and construct validity (their relationship with aggression and gender). A total of 238 adolescents participated in a two-wave survey and completed two media diaries. For game violence, the three self-report measures were reliable and valid. For television violence, only direct estimates achieved test-retest reliability and construct validity. Criterion validity could not be established for the television violence measures because the media diary was not a valid criterion for television violence. Our findings indicate that both direct estimates and favorites are valid measures for game violence, whereas for television violence, only direct estimates are valid. We conclude with a discussion about ways to further improve upon and reconceptualize media violence exposure measurement

Helping to distinguish primary from secondary transfer events for trace DNA.

DNA is routinely recovered in criminal investigations. The sensitivity of laboratory equipment and DNA profiling kits means that it is possible to generate DNA profiles from very small amounts of cellular material. As a consequence, it has been shown that DNA we detect may not have arisen from a direct contact with an item, but rather through one or more intermediaries. Naturally the questions arising in court, particularly when considering trace DNA, are of how DNA may have come to be on an item. While scientists cannot directly answer this question, forensic biological results can help in discriminating between alleged activities. Much experimental research has been published showing the transfer and persistence of DNA under varying conditions, but as of yet the results of these studies have not been combined to deal with broad questions about transfer mechanisms. In this work we use published data and Bayesian networks to develop a statistical logical framework by which questions of transfer mechanism can be approached probabilistically. We also identify a number of areas where further work could be carried out in order to improve our knowledge base when helping to address questions about transfer mechanisms. Finally, we apply the constructed Bayesian network to ground truth known data to determine if, with current knowledge, there is any power in DNA quantities to distinguish primary and secondary transfer events

Ballistic electron transport through magnetic domain walls

Electron transport limited by the rotating exchange-potential of domain walls is calculated in the ballistic limit for the itinerant ferromagnets Fe, Co, and Ni. When realistic band structures are used, the domain wall magnetoresistance is enhanced by orders of magnitude compared to the results for previously studied two-band models. Increasing the pitch of a domain wall by confinement in a nano-structured point contact is predicted to give rise to a strongly enhanced magnetoresistance.Comment: 4 pages, 2 figures; to appear in PRB as a brief repor

Tomography of full sawtooth crashes on the Tokamak Fusion Test Reactor

Full sawtooth crashes in high temperature plasmas have been investigated on the Tokamak Fusion Test Reactor (TFTR) [Plasma Phys. Controlled Fusion 33, 1509 (1991)]. A strong asymmetry in the direction of major radius, a feature of the ballooning mode, and a remaining m=1 region after the crash have been observed with electron cyclotron emission image reconstructions. The TFTR data is not consistent with two-dimensional (2-D) models; it rather suggests a three-dimensional (3-D) localized reconnection arising on the bad curvature side. This process explains the phenomenon of fast heat transfer which keeps the condition q0<1

Tomography of (2, 1) and (3, 2) magnetic island structures on Tokamak Fusion Test Reactor

High-resolution electron cyclotron emission (ECE) image reconstruction has been used to observe (m,n)=(2,1) and (3, 2) island structures on Tokamak Fusion Test Reactor [Plasma Phys. Controlled. Fusion 33, 1509 (1991)], where m and n are the poloidal and the toroidal mode number, respectively. The observed island structure is compared with other diagnostics, such as soft x-ray tomography and magnetic measurements. A cold elliptic island is observed after lithium pellet injection. Evidence for the enhancement of the heat transfer due to the island is observed. A relaxation phenomenon due to the m=2 mode is newly observed in Ohmic plasmas

Intra- and inter-annual uranium concentration variability in a Belizean stalagmite controlled by prior aragonite precipitation: A new tool for reconstructing hydro-climate using aragonitic speleothems

Aragonitic speleothems are increasingly utilised as palaeoclimate archives due to their amenability to high precision U–Th dating. Proxy records from fast-growing aragonitic stalagmites, precisely dated to annual timescales, can allow investigation of climatic events occurring on annual or even sub-annual timescales with minimal chronological uncertainty. However, the behaviour of many trace elements, such as uranium, in aragonitic speleothems has not thus far been as well constrained as in calcitic speleothems. Here, we use uranium concentration shifts measured across primary calcite-to-aragonite mineralogical transitions in speleothems to calculate the distribution coefficient of uranium in aragonitic speleothems (derived DU = 3.74 ± 1.13). Because our calculated DU is considerably above 1 increased prior aragonite precipitation due to increased karst water residence time should strongly control stalagmite aragonite U/Ca values. Consequently, uranium concentrations in aragonitic speleothems should act as excellent proxies for effective rainfall. We test this using a high-resolution ICP-MS derived trace element dataset from a Belizean stalagmite. YOK-G is an aragonitic stalagmite from Yok Balum cave in Belize with an extremely robust monthly-resolved chronology built using annual δ13C cycles. We interpret seasonal U/Ca variations in YOK-G as reflecting changes in the amount and seasonality of prior aragonite precipitation driven by variable rainfall amounts. The U/Ca record strongly suggests that modern drying has occurred in Belize, and that this drying was primarily caused by a reduction in wet season rainfall. This is consistent with published stable isotope data from YOK-G also very strongly suggesting modern rainfall reductions, previously interpreted as the result of southward ITCZ displacement. Our results strongly suggest that U/Ca values in aragonitic speleothems are excellent proxies for rainfall variability. This new tool, combined with the exceptional chronological control characteristic of aragonitic stalagmites and the high spatial resolution afforded by modern microanalytical techniques, should facilitate the construction of new exquisitely resolved rainfall records, providing rare insights into seasonality changes as well as long-term changes in local recharge conditions

Properties of branes in curved spacetimes

A generic property of curved manifolds is the existence of focal points. We show that branes located at focal points of the geometry satisfy special properties. Examples of backgrounds to which our discussion applies are AdS_m x S^n and plane wave backgrounds. As an example, we show that a pair of AdS_2 branes located at the north and south pole of the S^5 in AdS_5 x S^5 are half supersymmetric and that they are dual to a two-monopole solution of N=4 SU(N) SYM theory. Our second example involves spacelike branes in the (Lorentzian) plane wave. We develop a modified lightcone gauge for the open string channel, analyze in detail the cylinder diagram and establish open-closed duality. When the branes are located at focal points of the geometry the amplitude acquires most of the characteristics of flat space amplitudes. In the open string channel the special properties are due to stringy modes that become massless.Comment: 41 pages; v2:typos corrected, ref adde

Large Scale Structure Formation with Global Topological Defects. A new Formalism and its implementation by numerical simulations

We investigate cosmological structure formation seeded by topological defects which may form during a phase transition in the early universe. First we derive a partially new, local and gauge invariant system of perturbation equations to treat microwave background and dark matter fluctuations induced by topological defects or any other type of seeds. We then show that this system is well suited for numerical analysis of structure formation by applying it to seeds induced by fluctuations of a global scalar field. Our numerical results are complementary to previous investigations since we use substantially different methods. The resulting microwave background fluctuations are compatible with older simulations. We also obtain a scale invariant spectrum of fluctuations with about the same amplitude. However, our dark matter results yield a smaller bias parameter compatible with $b\sim 2$ on a scale of $20 Mpc$ in contrast to previous work which yielded to large bias factors. Our conclusions are thus more positive. According to the aspects analyzed in this work, global topological defect induced fluctuations yield viable scenarios of structure formation and do better than standard CDM on large scales.Comment: uuencoded, compressed tar-file containing the text in LaTeX and 12 Postscript Figures, 41 page