First-Time Attendee: How to Get the Most Out of Being a Student at a Music Library Association Meeting

When you are a student in library school, the thought of attending a Music Library Association Annual Meeting can seem both daunting and logistically challenging. You might feel unsure about how to socialize with professionals, or worry that your presence will be unwelcome. You may be concerned about negotiating the time off from classes and your library job(s) and wonder if you should just avoid that hurdle altogether. On top of that, the cost of lodging and travel could be a serious strain on the student budget. While all these concerns are perfectly valid, you may find that the benefits of attending MLA as a student far outweigh the costs.https://digitalcommons.chapman.edu/librarian_books/1008/thumbnail.jp

First-Time Attendee: How to Get the Most Out of Being a Student at a Music Library Association Meeting in Careers in Music Libraries IV

While grappling with gaining education and experience to enter into a career in music libraries, students may find attendance at an MLA meeting to be particularly beneficial. Going to an MLA meeting as a student is a fantastic experience that facilitates a better understanding of the profession and creates the opportunity to make connections that can lead to greater success when entering a career in music libraries. From plenary presentations to informal gatherings, there are numerous opportunities to immerse yourself and learn about salient topics in music library work while also meeting potential collaborators, mentors, and future colleagues. In this new chapter, Taylor Greene and Zoua Sylvia Yang draw upon their experience attending national and regional MLA conferences as former student attendees and current music librarians. They provide guidance to help future music librarians and first-time attendees figure out what to expect from MLA national and local chapter meetings and to understand the importance of networking, with tips on doing it (even if you don’t want to!). They also provide advice for getting the most out of your MLA experience and pivoting from the conference to the job market

Regional Congruence of Vegetation and Summer Climate Patterns in the Queen Elizabeth Islands, Northwest Territories, Canada

In the Queen Elizabeth Islands, regional distributions of vegetation and many summer climate patterns show similar, distinctive S-shaped patterns, a response to the interaction between regional topography and persistent northwesterly flow from the central Arctic Ocean. The cool and cloudy central polar pack ice climate bulges almost unimpeded into the low-lying islands of the northwest and north-central sector. This region has the least vascular plant diversity and is dominated almost entirely by the herbaceous species. The mountains of Axel Heiberg and Ellesmere islands create a barrier that effectively shelters an intermontane region from both the central Arctic Ocean climate and travelling cyclonic systems. In this large intermontane zone regional minimums of cloud cover and maximums of temperatures and melt season duration are found. This area contains the most dense and diverse vascular plant assemblages. Woody species and sedges dominate, and many species with more southerly limits occur as disjuncts. The plateaus and highlands in the southern islands modify the central Arctic Ocean climate sufficiently to produce an intermediate climate. Woody species and sedges also dominate this area; however, the density and diversity are less than that of the intermontane area. Several phytogeographic limits occur in the Queen Elizabeth Islands, including the northern limits of woody plants and sedges, and the northern limits of the dominance of woody plants and sedges. These regional boundaries roughly coincide with regional mean July isotherms of 3 and 4°C respectively.Key words: Arctic, High Arctic, arctic vegetation, Canada, climate, summer climate, bioclimatic zones, Queen Elizabeth Islands, phytogeographical boundariesMots clés: Arctique, Extrême-Arctique, végétation arctique, Canada, climat, climat estival, zones bioclimatiques, îles de la Reine-Elizabeth, limites phytogéographique

Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in children worldwide and is a significant cause of hospital admissions in young children in England. No RSV vaccine has been licensed but a number are under development. In this work, we present two structurally distinct mathematical models, parameterized using RSV data from the UK, which have been used to explore the effect of introducing an RSV paediatric vaccine to the National programme. We have explored different vaccine properties, and dosing regimens combined with a range of implementation strategies for RSV control. The results suggest that vaccine properties that confer indirect protection have the greatest effect in reducing the burden of disease in children under 5 years. The findings are reinforced by the concurrence of predictions from the two models with very different epidemiological structure. The approach described has general application in evaluating vaccine target product profiles

Vida Carson, Sylvia Ashler, Howard Jones and Thornton Taylor to James Meredith (7 October 1962)

https://egrove.olemiss.edu/mercorr_pro/1838/thumbnail.jp

Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South Africa

<p>Abstract</p> <p>Background</p> <p>Treatment of women for high-grade cervical cancer precursors frequently results in clearance of the associated high-risk human papillomavirus (hrHPV) infection but the role of treatment among women without hrHPV is unknown. We investigated whether cervical cryotherapy reduces newly detected hrHPV infections among HIV-positive and HIV-negative women who were hrHPV negative when treated.</p> <p>Methods</p> <p>The impact of cryotherapy on newly detected hrHPV infections was examined among 612 women of known HIV serostatus, aged 35 to 65 years, who were negative for hrHPV DNA, and randomized to either undergo cryotherapy (n = 309) or not (n = 303). All women underwent repeat hrHPV DNA testing 6, 12, 24, and 36 months later.</p> <p>Results</p> <p>Among 540 HIV-negative women, cryotherapy was associated with a significant reduction in newly detected hrHPV infections. Women in the cryotherapy group were 55% less likely to have newly detected hrHPV than women in the control group (95% CI 0.28 to 0.71). This association was independent of the influence of changes in sexual behaviors following therapy (adjusted hazards ratio (HR) = 0.49, 95% CI 0.29 to 0.81). Among 72 HIV-positive women, similar reductions were not observed (HR = 1.10, 95% CI 0.53 to 2.29).</p> <p>Conclusions</p> <p>Cervical cryotherapy significantly reduced newly detected hrHPV infections among HIV-negative, but not HIV-positive women. These results raise intriguing questions about immunological responses and biological mechanisms underlying the apparent prophylactic benefits of cryotherapy.</p

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes

Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and β cell dysfunction. We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin. CE stabilize the ER-associated protein degradation (ERAD) system and promote misfolded proinsulin proteasomal degradation. This involves activation of nuclear and membrane estrogen receptor-α (ERα), promoting transcriptional repression and proteasomal degradation of the ubiquitin-conjugating enzyme and ERAD degrader, UBC6e. The selective ERα modulator bazedoxifene mimics CE protection of β cells in females but not in males. : Estrogens prevent diabetes in women, but the mechanism is poorly understood. Xu et al. report that estrogens activate the endoplasmic-reticulum-associated protein degradation pathway, which promotes misfolded proinsulin degradation, suppresses endoplasmic reticulum stress, and protects insulin secretion in mice and in human pancreatic β cells. Keywords: estrogens, beta cell, islet, endoplasmic reticulum stress, proinsulin misfolding, diabetes, bazedoxifene, sex dimorphism, ERAD, SER

The Iowa Homemaker vol.41, no.7

Foolproof Bachelor Budget, Gaylin Morgan, page 4 A “Lone Male”, Joy Reese, page 5 It All Started With ADAM, Sherry Stoddard, page 6 Going Forth, Dan Taylor, page 9 Bottled Beauty Since 1600 B.C., Diane Sharbo, page 10 What’s the Matter?, Bob MacDonough, page 11 The Awful Beginning, Don Wishart, page 12 Found: Scientific Formula for Women, page 15 When Men Entertain, Sylvia Noid, page 16 The Man Behind “the lady from Hancock”, LaVeda Jansonius, page 16 “We Want Steak!”, Barb Pierson, page 1

Comparison of the prevalence of common bacterial pathogens in the oropharynx and nasopharynx of gambian infants.

BACKGROUND: CRM- based pneumococcal conjugate vaccines generally have little impact on the overall prevalence of pneumococcal carriage because of serotype replacement. In contrast, protein vaccines could substantially reduce the overall prevalence of pneumococcal carriage with potential microbiological and clinical consequences. Therefore, trials of pneumococcal protein vaccines need to evaluate their impact on carriage of other potentially pathogenic bacteria in addition to the pneumococcus. METHODS: As a prelude to a trial of an investigational pneumococcal vaccine containing pneumococcal polysaccharide conjugates and pneumococcal proteins, the prevalence of carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella species and Staphylococcus aureus in the nasopharynx of 1030 Gambian infants (median age 35 weeks) was determined. An oropharyngeal swab was obtained at the same time from the first 371 infants enrolled. Standard microbiological techniques were used to evaluate the bacterial flora of the pharynx and to compare that found in the oropharynx and in the nasopharynx. RESULTS: The overall pneumococcal carriage rate was high. Isolation rates of S. pneumoniae and Moraxella species were significantly higher using nasopharyngeal rather than oropharyngeal swabs (76.1% [95% CI 73.4%,78.7%] vs. 21.3% [95% CI 17.2%,25.8%] and 48.9% [95% CI 45.8%, 52.0%] vs. 20.5% % [95% CI 16.5%,25.0%] respectively). In contrast, S. aureus and H. influenzae were isolated more frequently from oropharyngeal than from nasopharyngeal swabs (65.0% [95% CI 59.9%, 69.8%] vs. 33.6% [95% CI 30.7%, 36.5%] and 31.8% [95% CI 16.5%, 25.0%] vs. 22.4% [95% CI 19.9%, 25.1%] respectively). No group A β haemolytic streptococci were isolated. CONCLUSION: Collection of an oropharyngeal swab in addition to a nasopharyngeal swab will provide little additional information on the impact of a novel pneumococcal vaccine on pneumococcal carriage but it might provide additional, valuable information on the impact of the vaccine on the overall microbiota of the pharynx