4,401 research outputs found
Application of digital particle image velocimetry to insect aerodynamics: measurement of the leading-edge vortex and near wake of a Hawkmoth.
Some insects use leading-edge vortices to generate high lift forces, as has been inferred from qualitative smoke visualisations of the flow around their wings. Here we present the first Digital Particle Image Velocimetry (DPIV) data and quantitative analysis of an insect’s leading-edge vortex and near wake at two flight speeds. This allows us to describe objectively 2D slices through the flow field of a tethered Tobacco Hawkmoth (Manduca sexta). The near-field vortex wake appears to braodly resemble elliptical vortex loops. The presence of a leading-edge vortex towards the end of the downstroke is found to coincide with peak upward force production measured by a six-component force–moment balance. The topology of Manduca’s leading-edge vortex differs from that previously described because late in the downstroke, the structure extends continuously from wingtip across the thorax to the other wingtip
Long term changes in health-related quality of life for people with heart failure:the ECHOES study
Aims: Heart failure (HF) impairs all aspects of health-related quality of life (HRQoL), but little is known about the effect of developing HF on HRQoL over time. We aimed to report changes in HRQoL over a 13-year period. Methods and results: HRQoL was measured in the Echocardiographic Heart of England Screening (ECHOES) study and the ECHOES-X follow-up study (N = 1618) using the SF-36 questionnaire (Version 1). Mixed modelling compared changes in HRQoL across diagnostic groups, adjusting for potential predictors and design variables. Patients who had developed HF with reduced ejection fraction (HFrEF) or HF with preserved ejection fraction (HFpEF) at rescreening had significantly greater reduction in physical functioning (PF) and role physical (RP) scores compared with those without HF; adjusted mean difference in PF: HFrEF −16.1, [95% confidence interval (CI) −22.2 to −10.1]; HFpEF −14.6, (95% CI −21.2 to −8.1); in RP: HFrEF −20.7, (95% CI −31.8 to −9.7); HFpEF −19.3, (95% CI −31.0 to −7.6). Changes in HRQoL of those with a HF diagnosis at baseline and rescreen, with exception of role emotion, were similar to those without HF but started from a much lower baseline score. Conclusions: People with a new diagnosis of HF at rescreening had a significant reduction in HRQoL. Conversely, for those with HF detected on initial screening, little change was observed in HRQoL scores on rescreening. Further research is required to understand the development of HF over time and to test interventions designed to prevent decline in HRQoL, potentially through earlier diagnosis and treatment optimization.</p
Magnetorotational Instability in Liquid Metal Couette Flow
Despite the importance of the magnetorotational instability (MRI) as a
fundamental mechanism for angular momentum transport in magnetized accretion
disks, it has yet to be demonstrated in the laboratory. A liquid sodium
alpha-omega dynamo experiment at the New Mexico Institute of Mining and
Technology provides an ideal environment to study the MRI in a rotating metal
annulus (Couette flow). A local stability analysis is performed as a function
of shear, magnetic field strength, magnetic Reynolds number, and turbulent
Prandtl number. The later takes into account the minimum turbulence induced by
the formation of an Ekman layer against the rigidly rotating end walls of a
cylindrical vessel. Stability conditions are presented and unstable conditions
for the sodium experiment are compared with another proposed MRI experiment
with liquid gallium. Due to the relatively large magnetic Reynolds number
achievable in the sodium experiment, it should be possible to observe the
excitation of the MRI for a wide range of wavenumbers and further to observe
the transition to the turbulent state.Comment: 12 pages, 22 figures, 1 table. To appear in the Astrophysical Journa
Nimbus 7 solar backscatter ultraviolet (SBUV) ozone products user's guide
Three ozone tape products from the Solar Backscatter Ultraviolet (SBUV) experiment aboard Nimbus 7 were archived at the National Space Science Data Center. The experiment measures the fraction of incoming radiation backscattered by the Earth's atmosphere at 12 wavelengths. In-flight measurements were used to monitor changes in the instrument sensitivity. Total column ozone is derived by comparing the measurements with calculations of what would be measured for different total ozone amounts. The altitude distribution is retrieved using an optimum statistical technique for the inversion. The estimated initial error in the absolute scale for total ozone is 2 percent, with a 3 percent drift over 8 years. The profile error depends on latitude and height, smallest at 3 to 10 mbar; the drift increases with increasing altitude. Three tape products are described. The High Density SBUV (HDSBUV) tape contains the final derived products - the total ozone and the vertical ozone profile - as well as much detailed diagnostic information generated during the retrieval process. The Compressed Ozone (CPOZ) tape contains only that subset of HDSBUV information, including total ozone and ozone profiles, considered most useful for scientific studies. The Zonal Means Tape (ZMT) contains daily, weekly, monthly and quarterly averages of the derived quantities over 10 deg latitude zones
On the Phenomenology of Hydrodynamic Shear Turbulence
The question of a purely hydrodynamic origin of turbulence in accretion disks
is reexamined, on the basis of a large body of experimental and numerical
evidence on various subcritical (i.e., linearly stable) hydrodynamic flows.
One of the main points of this paper is that the length scale and velocity
fluctuation amplitude which are characteristic of turbulent transport in these
flows scale like , where is the minimal Reynolds number for
the onset of fully developed turbulence. From this scaling, a simple
explanation of the dependence of with relative gap width in subcritical
Couette-Taylor flows is developed. It is also argued that flows in the shearing
sheet limit should be turbulent, and that the lack of turbulence in all such
simulations performed to date is most likely due to a lack of resolution, as a
consequence of the effect of the Coriolis force on the large scale fluctuations
of turbulent flows.
These results imply that accretion flows should be turbulent through
hydrodynamic processes. If this is the case, the Shakura-Sunyaev
parameter is constrained to lie in the range in accretion
disks, depending on unknown features of the mechanism which sustains
turbulence. Whether the hydrodynamic source of turbulence is more efficient
than the MHD one where present is an open question.Comment: 31 pages, 3 figures. Accepted for publication in Ap
The custom-made titanium orbital floor prosthesis in reconstruction for orbital floor fractures
The custom-made titanium orbital floor prosthesis in reconstruction for orbital floor fracture
Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair
DNA ligase III and the essential protein XRCC1 are present at greatly reduced levels in the xrcc1 mutant CHO cell line EM-C11. Cell-free extracts prepared from these cells were used to examine the role of the XRCC1 gene product in DNA base excision repair in vitro. EM-C11 cell extract was partially defective in ligation of base excision repair patches, in comparison to wild type CHO-9 extracts. Of the two branches of the base excision repair pathway, only the single nucleotide insertion pathway was affected; no ligation defect was observed in the proliferating cell nuclear antigen-dependent pathway. Full complementation of the ligation defect in EM-C11 extracts was achieved by addition to the repair reaction of recombinant human DNA ligase III but not by XRCC1. This is consistent with the notion that XRCC1 acts as an important stabilizing factor of DNA ligase III. These data demonstrate for the first time that xrcc1 mutant cells are partially defective in ligation of base excision repair patches and that the defect is specific to the polymerase beta-dependent single nucleotide insertion pathway
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