Visual Recognition Difficulties: Identifying Primary School Students\u27 Directional Confusion In Writing Letters And Numbers

Background: Occupational therapists often assess primary school learners for letter and number reversal tendencies using scales which require recognition of reversed letters and numbers; however, these scales do not generally look at learners’ written production of letters and numbers to measure their reversal tendencies. This study aimed to determine whether learners reverse the same letters and numbers in reading and in writing. Method: This study utilised the Richmond Reversal Rating (RRR) Scale to identify which language symbols 118 primary school learners found difficult to recognise as being reversed when reading a series of letters and numbers and writing 20 letters and nine numerals. Analysis: Nonparametric correlations and parametric Chi-square statistics were used to investigate differences in the learners’ reading recognition and written production. Results: Letters and numbers reversed in recognition (reading) and writing were similar. Moreover, eleven letters and three numbers were identified as difficult to orientate on a page. Conclusion: Explicit teaching to remediate letter and number reversals and font use are paramount to improving language symbol orientation

Photoaging photography: Mothers\u27 attitudes toward adopting skin-protective measures pre- and post-viewing photoaged images of their and their child\u27s facial sun damage

One of the major sources for children to gain knowledge of skin-protective measures is from their parents. Therefore, an imperative exists for parents to model and reinforce the sun-safety practices they want their children to adopt. Although Australian mothers have been the recipients of two extensive sun-safety public health campaigns, little is known about their attitudes, behaviors, and application of health promotion knowledge toward their and their child’s ultraviolet (UV) sun exposure. Ten mothers with children aged 4 to 12 years were asked a series of questions about their sun-safety practices, both pre- and post-viewing an UV photoaged photograph of their and their child’s face. Interpretive Phenomenological Analysis identified four themes and 12 subthemes. The findings reveal that mothers expressed divergent views on skin protection pre- and post-inspecting their and their child’s photoaged photographs. At one end of the viewing spectrum, mothers expressed an opinion that some degree of skin damage was an inevitable reality in Australia’s sunny climate, and on the other end of the viewing spectrum mothers expressed their desire to keep themselves and their child out of the sun. Mothers in the mid-range of the spectrum stated that their parenting task was one of transferring the responsibility for adopting skin-protective measures from themselves to their preteen children. The combination of mothers viewing their own photos as well as their child’s photograph serves to enhance the difference seen in photoaging damage, which in turn provides greater impetus for mothers to be concerned about photoaging in general

\u27You get forced to live with randoms ... and that makes you stronger as a person\u27. Homeless Western Australian teenagers\u27 perspectives on their experiences of residing in crisis accommodation

Homelessness is a growing, but poorly understood, social phenomenon. It is hypothesised that the fulfilment of homeless teenagers’ psychosocial needs supports normative development and facilitates mental well-being. This exemplar phenomenological study investigated the crisis accommodation living experiences of eight homeless teenagers aged 16 to 19 years and interpreted these experiences in relation to Maslow’s hierarchy of human need. The findings reveal that homeless teenagers achieve a measure of resilience by overcoming their safety fears and subsequently establishing a sense of belonging within the homeless community. Finally, the teenagers’ ability, under difficult circumstances, to establish an identity, individuality, and integrity seemingly provided them with sufficient internal fortitude that they were then able to set and achieve their personal goals

Young australian adults’ reactions to viewing personalised uv photoaged photographs

Background: Despite two nationwide sun-protection awareness campaigns, young Australian adults continue to sunbathe. Since their primary motivation for tanning is appearance enhancement, it may well be that campaigns that highlight the negative effects of tanning on appearance are more effective than campaigns that emphasise the health risks associated with sun exposure.Aims: This study aims to explore young adults’ reactions to viewing a photoaged photograph of the sun damage already visible in their facial image.Methods: Semi-structured interviews were conducted with seven females and three males aged 20-30 years. The interview transcripts were transcribed verbatim and were then subjected to Interpretive Phenomenological Analysis (IPA).Results: Three themes and eight sub-themes emerged from the analysis. Collectively they revealed that participants’ fear-based reaction to their photoaged photographs triggered in them feelings of unattractiveness, which in turn motivated them to change to their existing sun-tanning behaviours.Conclusion: Although media-popularised representations of suntanned skin being the desired norm were identified as a barrier to skin-protective behavioural change, personalised ultraviolet (UV) photoaged photographs, when accompanied by an explanation of the skin damage that unprotected ultraviolet radiation (UVR) exposure causes, were effective in changing young adults’ sun-tanning intentions. Hence, a need exists for positive non-tanning appearance-related messages to be incorporated into sun exposure education campaigns

“Keeping It Together, Keeping Their Heads Above Water”: Western Australian Child Health Nurses’ Understanding Of Resilience In Postpartum Mothers

Assessing the well-being of postpartum mothers is an important aspect of postnatal nursing care. For this reason, Child Health Nurses (CHNs) are charged with the responsibility of identifying postpartum mothers who do/not manifest resilient behavioral qualities. However, little is known about CHNs’ conceptualization of resilience or how they assess resilience in postpartum mothers. This exemplar study addressed this knowledge shortfall by conducting semi-structured interviews with eight practicing CHNs. The study’s findings reveal that although CHNs’ conceptual understanding of resilience is congruent with current theoretical thinking, some variance does exist in the ways in which CHNs assess postpartum resilience, particularly, in relation to CHNs’ use of intuitive assessment techniques to appraise the critical maternal postpartum coping qualities of adaptation, responsiveness, self-confidence, and social connectedness

Mapping Schistosoma haematobium for Novel Interventions against Female Genital Schistosomiasis and Associated HIV Risk in KwaZulu-Natal, South Africa

publishedVersio

Antioxidant Protects against Increases in Low Molecular Weight Hyaluronan and Inflammation in Asphyxiated Newborn Pigs Resuscitated with 100% Oxygen

BACKGROUND: Newborn resuscitation with 100% oxygen is associated with oxidative-nitrative stresses and inflammation. The mechanisms are unclear. Hyaluronan (HA) is fragmented to low molecular weight (LMW) by oxidative-nitrative stresses and can promote inflammation. We examined the effects of 100% oxygen resuscitation and treatment with the antioxidant, N-acetylcysteine (NAC), on lung 3-nitrotyrosine (3-NT), LMW HA, inflammation, TNFα and IL1ß in a newborn pig model of resuscitation. METHODS & PRINCIPAL FINDINGS: Newborn pigs (n = 40) were subjected to severe asphyxia, followed by 30 min ventilation with either 21% or 100% oxygen, and were observed for the subsequent 150 minutes in 21% oxygen. One 100% oxygen group was treated with NAC. Serum, bronchoalveolar lavage (BAL), lung sections, and lung tissue were obtained. Asphyxia resulted in profound hypoxia, hypercarbia and metabolic acidosis. In controls, HA staining was in airway subepithelial matrix and no 3-NT staining was seen. At the end of asphyxia, lavage HA decreased, whereas serum HA increased. At 150 minutes after resuscitation, exposure to 100% oxygen was associated with significantly higher BAL HA, increased 3NT staining, and increased fragmentation of lung HA. Lung neutrophil and macrophage contents, and serum TNFα and IL1ß were higher in animals with LMW than those with HMW HA in the lung. Treatment of 100% oxygen animals with NAC blocked nitrative stress, preserved HMW HA, and decreased inflammation. In vitro, peroxynitrite was able to fragment HA, and macrophages stimulated with LMW HA increased TNFα and IL1ß expression. CONCLUSIONS & SIGNIFICANCE: Compared to 21%, resuscitation with 100% oxygen resulted in increased peroxynitrite, fragmentation of HA, inflammation, as well as TNFα and IL1ß expression. Antioxidant treatment prevented the expression of peroxynitrite, the degradation of HA, and also blocked increases in inflammation and inflammatory cytokines. These findings provide insight into potential mechanisms by which exposure to hyperoxia results in systemic inflammation

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine