Genome-wide association study for systemic lupus erythematosus in an egyptian population

Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian ancestries, while many other ethnic populations remain underexplored. We conducted the first SLE GWAS on Egyptians–an admixed North African/Middle Eastern population–using 537 patients and 883 controls. To identify novel susceptibility loci and replicate previously known loci, we performed imputation-based association analysis with 6,382,276 SNPs while accounting for individual admixture. We validated the association analysis using adaptive permutation tests (n = 109). We identified a novel genome-wide significant locus near IRS1/miR-5702 (Pcorrected = 1.98 × 10−8) and eight novel suggestive loci (Pcorrected 0.8) with lead SNPs from four suggestive loci (ARMC9, DIAPH3, IFLDT1, and ENTPD3) were associated with differential gene expression (3.5 × 10−95 < p < 1.0 × 10−2) across diverse tissues. These loci are involved in cellular proliferation and invasion—pathways prominent in lupus and nephritis. Our study highlights the utility of GWAS in an admixed Egyptian population for delineating new genetic associations and for understanding SLE pathogenesis

RADIO ACCESS NETWORK REQUIREMENT FOR NEW DEPLOYMENT OF WIMAX IN DHAKA

Mobile WiMAX is expected to be the next generation radio-interface, complementing WLAN and challenging EVDO/HSPA/LTE. High speed data rate, reduced latency, better Quality of service, and mobility can allow WiMAX to meet the rapidly growing demand of the users. A study of WiMAX Radio Network Planning (RNP) for an urban area like Dhaka city in Bangladesh is presented in this paper in order to help predetermine the radio access infrastructure requirements. A suitable radio planning tool has been used for this purpose. The simulation results of throughput and Carrier to Interference plus Noise Ratio (CINR) are provided