SOME ISSUES OF THE THEORY OF ECONOMIC INTEGRATION AND PRACTICE OF MEGA-REGIONAL AGREEMENTS

The author gives a definition of mega-agreements and outlines their qualitative characteristics such as versatility, extra regionality, large scale, regulatory questions which do not fall in WTO competence. Quantitative criteria of mega-integration (a cumulative share of alliance in the world trade, GWP, world investments, market capacity) and their threshold values are offered. It is proved that mega- agreements’ practice does not conform to the majority of requirements for the linearly-stadial model devised by B. Balassa. Specific features of TTP and TTIP are revealed on the basis of the hub-and-spoke model

Бытие как фактор взаимодействия и развития трансцендентных и трансцендентальных отношений

In this atical devoted about the time reason possibly in the future speedy permission for the and future civilization about it resemble development the scientific paradigma of the Russia to-day. The speech no aboute «europecentrist» model or the «western» scheme of the historical process, but the large importance in the character existence append the interaction, mutual understanding and mutual assistance of the etnos, that is base foundation of the generally the mankind. And no only to-day! What does the possibility to decide the basic question of the lifе without the politic measure. The answer on the question can make only the time.Автором статьи подняты вопросы о том, что является основным фактором взаимодействия и развития трансцендентных и трансцендентальных отношений в обществе. Возможно, в скором будущем он будет способствовать успеху цивилизации. Речь не идет о «европоцентристской» или «западнической» модели исторического процесса. Наибольшую важность в характере развития бытия, по мнению автора статьи, приобретают взаимодействие, взаимопонимание и взаимопомощь этносов. Однако, ответ на вопрос о том, возможно ли решить на этой основе вопрос перспективы для человечества в целом, даст только время

Вопросы отражения шестой парадигмы глобализма в религиоведении Дагестана

Автором статьи предпринята попытка рассмотреть роль религиоведения Дагестана в развитии социума через конфессиональный и научный опыт в определении категориального отражения шестой парадигмы глобализма. Проводимые социологические опросы показывают, что население нуждается в научных знаниях, порой испытывает в них острую необходимость. Это касается категории учителей школ, гимназий, лицеев

Наука: ключевой вопрос современности

In the article analyses the role and importance of scientific knowledge as a major source of objective knowledge about the development of the society nature and the man. The author is par attention the role of the modern science for the mankind, ask on so that scientific picture of the world perception how is existing in the reality, only no visible. Absolute, the science no is perceiving, passionately and accurate mirror, which is reflected the world in the concepts and the mathematical calculations, but she is how consequence of the evolution consciousness of the people, which are respected the world of ideas, and is develop successful in Dagestan

Суфизм – онтология истинного

The author pay attention on the problem еthic of the sufism in the relative field ethos, when the ethical thought … the man experience the difficultys in the cultural and spiritual attitude, anexample for his the gods, to spend the time in the intence reconnaissance raid of the meaning life and further life program. Trying to save his individuality, the man long the best shape, but no strugle with the realism, for touch the ethical sufism. The different cultures and the different traditions, inherent to the peoples of the Russia, compile the unity carpet of the unitycultur field of the ethoc. Showing influence jn the each concrete man, the ethos how the general ways and manners of the mankind – has the right to give for him the suchas field of the activities, the such as possibility for the interaction with another culturs, which can to fortify in him the belief the hope on the further perspective of the life, in which no was sinking performance and more concrete useful and construction actions, so need the further time. The unity of the culture must to bring to the allworld, global prossec: from integration – to the trancformation of the social structures.В этой статье автор делает акцент на важных проблемах суфизма, рассматривая их как онтологию подлинного. Автор бращает внимание на вопросы этики в релятивном поле этоса, когда этическая мысль заставляет человека задуматься о том, какова причина трудностей в культурном и духовном отношении, заняться напряженным поиском смысла своей жизни, осуществляя труд души. Человек надеется на лучшее, стремясь сохранить свою индивидуальность, но не методом борьбы с реальностью, не вступая с ней в противоречие, а на основе гармонизации своей жизни, чему учит этика суфизма, соблюдением культуры и традиций, которые присущи народам России, поддерживая общекультурное поле этоса. Оказывая влияние на каждого конкретного человека, этос как общий значимый путь для человечества, может активизировать человека, дать опыт взаимодействия с другими культурами, укрепить надежду на хорошую перспективу не в мистическом образе, а в конкретном представлении, что так необходимо в будущем времени. Единство культуры должно привести к общемировому, глобальному процессу, от интеграции – к трансформации социальных структур

The impact of lifestyle factors on age-related differences in hair trace element content in pregnant women in the third trimester

BACKGROUND: Trace elements play a significant role in the regulation of human reproduction, while advanced age may have a significant impact on trace element metabolism. The objective of the present study was to assess the impact of lifestyle factors on age-related differences in hair trace element content in pregnant women in the third trimester. METHODS: A total of 124 pregnant women aged 20–29 (n = 72) and 30–39 (n = 52) were ex- amined. Scalp hair trace element content was assessed using inductively coupled plasma mass spectrometry at NexION 300D (Perkin Elmer, USA) after microwave digestion. RESULTS: The results showed that the elder pregnant women had 36% (p = 0.009), 14% (p = 0.045), and 45% (p = 0.044) lower hair Zn, V, and Cd content, and 16% (p = 0.044) higher hair B levels – in comparison to the respective younger group values. Multiple regression analysis demonstrated that the age of the women had a significant influence on hair V and Zn levels. B content was also significantly influenced by age at first intercourse, smoking status, and specific dietary habits. None of the lifestyle factors were associated with hair Cd content in pregnant women. Hair V levels were also affected by following a special diet. Interestingly, alcohol intake did not have a significant impact on hair trace element content. CONCLUSIONS: These data indicate that lifestyle factors have a significant influence on age-related changes in hair trace elements during pregnancy that may impact the outcome of pregnancy

Outcomes of the multicenter monitoring of the causative agent of invasive listeriosis in the metropolis

Introduction. Invasive listeriosis is a rare disease posing a threat to high-risk groups and often leading to a fatal outcome. Its causative agent is Listeria monocytogenes, a ubiquitous saprophyte that has turned into an important foodborne pathogen with the growing industry of semi-cooked and ready-to-eat products. The aim of the study is the characterization of L. monocytogenes isolates in the Moscow region and identification of possible causes of susceptibility to infection Materials and methods. The multicenter monitoring of L. monocytogenes was conducted in the Moscow metropolitan area, using bacteriological and genomic methods for description of the pathogen, medical history collection and detailed analysis of patient case summaries. Results. In the cohorts of patients with perinatal listeriosis (PL) and meningitis-septicemia (MS), invasive listeriosis had a year-round occurrence with slight upswings in MarchApril and JulyNovember. During the COVID-19 pandemic, in the MS group, the minimum age of patients decreased to 31 years and the proportion of deaths increased 1.57-fold compared to 20182019. During the pandemic, an increase in the diversity of L. monocytogenes genotypes was observed, along with changes in the spectrum of pathogen genotypes throughout the pandemic stages. During the monitoring, a total of 73 L. monocytogenes clinical isolates belonging to 24 genotypes were described. Seven genotypes belonged to the first phylogenetic lineage (PLI); 14 genotypes belonged to PLII. The PL cohort had the highest proportion of PLI genotypes (52%). In the MS cohort, the group of men had the widest diversity of genotypes, 6 of which were identical to genotypes of food isolates. In the analysed set of isolates, 12 new profiles of internalin genes were identified and described. The whole genome sequencing detected the presence of plasmids in 9 of 58 genomes of clinical isolates. The comparison of core genomes revealed an epidemic relationship between isolates of the same genotype for ST4, ST21, and ST425. Conclusion. The performed study presents a detailed description of the diversity and virulence of L. monocytogenes circulating in the Moscow metropolitan area, thus providing information for timely diagnosis and treatment of invasive listeriosis

Design, synthesis, computational and biological evaluation of new anxiolytics

Abstract New anxiolytics have been discovered by prediction of biological activity with computer programs PASS and DE DEREK for a heterogeneous set of 5494 highly chemically diverse heterocyclic compounds (thiazoles, pyrazoles, isatins, a fused imidazoles and others). The majority of tested compounds exhibit the predicted anxiolytic effect. The most potent activity was found in 2 (4 nitro phenyl) 3 (4 phenylpiperazinomethyl)imidazo[1,2 a]pyridine 8, 1 [(4 bromophenyl) 2 oxoethyl] 3 (1,3 dioxolano) 2 indolinone 3, 5 hydroxy 3 methoxycarbonyl 1 phenylpyrazole 5 and 2 (4 fluorophenyl) 3 (4 methylpiperazinomethyl)imidazo[1,2 a]pyridine 7. The application of the computer assisted approach significantly reduced the number of synthesized and tested compounds and increased the chance of finding new chemical entities (NCEs)