The relationship between serum lipid levels and lifetime suicide attempts in patients with schizophrenia

Patients with schizophrenia have a higher risk of suicide than the general population. Due to these high rates, researchers are investigating biomarkers associated with suicidal behavior to prevent suicide. Conflicting findings have also been reported in studies investigating the relationship between cholesterol and suicide in patients with schizophrenia. The aim of our study was to compare schizophrenia patients with and without a history of suicide attempt in terms of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels and to investigate the relationship between cholesterol levels and lifetime suicide attempts. A retrospective, cross-sectional study was carried out in a psychotic disorders outpatient clinic at a psychiatric hospital in Turkey. Two hundred and twenty-eight patients with schizophrenia were evaluated. We present a retrospective analysis of longitudinal data addressing socio-demographic characteristics, metabolic parameters, lipid profile, scales. Lifetime suicide attempts were reported by %28 of patients. It was found that schizophrenia patients with suicide attempt had higher TC and TG levels than schizophrenia patients without suicide attempt. Similar findings were repeated male patients with schizophrenia. In female patients, only TG level showed a significant difference between those with and without suicide attempt. Our findings indicate an association between high cholesterol levels and lifetime suicidality. The findings of our study may indicate that lifetime suicide attempt in schizophrenia exhibits a different lipid profile. [Med-Science 2018; 7(4.000): 826-30

[The Relationship Between Emotion Recognition and the Symptoms of Attention Deficit and Impulsivity in Adult Patients With Attention Deficit Hyperactivity Disorder].

Purpose: Interpersonal relationship disorders in adults with Attention Deficit Hyperactivity Disorder (ADHD) can be associated with the impairment of non-verbal communication. The purpose of our study was to compare the emotion recognition, facial recognition and neuropsychological assessments of adult ADHD patients with those of healthy controls, and to thus determine the effect of neuropsychological data on the recognition of emotional expressions

The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: Results from the EU-GEI study

Background The relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little is known about the relationship between subtypes of trauma and specific symptoms in patients, their siblings, and controls. It is also not clear which variables mediate the relationship between trauma and psychotic symptoms. Methods Seven hundred and forty-two patients with SCZ, 718 of their unaffected siblings and 1039 controls from three EU-GEI sites were assessed for CT, symptom severity, and cognitive schemas about self/others. CT was assessed with the Childhood Trauma Questionnaire, and cognitive schemas were assessed by The Brief Core Schema Scale. Results Patients with psychosis were affected by CT more than their siblings and controls in all domains. Childhood emotional abuse and neglect were more common in siblings than controls. CT was related to negative cognitive schemas toward self/others in patients, siblings, and controls. We found that negative schemas about self-mediated the relationship between emotional abuse and thought withdrawal and thought broadcasting. Approximately 33.9% of the variance in these symptoms was explained by the mediator. It also mediated the relationship between sexual abuse and persecutory delusions in SCZ. Conclusions Our findings suggest that childhood abuse and neglect are more common in patients with schizophrenia than their siblings and healthy controls, and have different impacts on clinical domains which we searched. The relationship between CT and positive symptoms seems to be mediated by negative cognitive schemas about self in schizophrenia