Development of Scroll Compressor for 16HP VRF System

Usage of multiple compressors is applied for general VRF system at more than 12HP capacity because it is difficult to keep capacity and performance by usage of one compressor for such large capacity system. But usage of multiple compressors has problem controlling cost and keeping oil level in each compressor. In this paper, new scroll compressor which can reduce oil circulation in refrigerant circuit, keep oil level in the compressor, keep high capacity and performance and operate in a wide running range and can be applied until 16HP capacity by usage of one compressor was developed. It is important to keep oil level in a compressor because VRF system has large refrigerant circuit. Analysis of oil and refrigerant flow in the compressor was applied and structure of preventing oil agitation was introduced to reduce oil circulation in refrigerant circuit and keep oil level. The compressor for VRF system is demanded to operate in a wide running range from low speed to high speed and from low load to high load. This compressor can supply oil even if rotational speed is low because this compressor supplies oil by differential pressure and can supply enough oil at low differential pressure by new structure of oil lubrication, therefore running range become wider. And analysis of lubrication between shaft and bearing was applied and this compressor can keep reliability against high load at large capacity by optimal structure

An Interdisciplinary Approach for ESD-oriented Understanding of Natural Environmental Systems through Collaboration between Meteorology and Botany: Practical Trials in University Classes

理科の学問分野である気象学と植物学との連携により，持続可能な開発のための教育（ESD）を志向した自然環境系の理解を目指し，大学の教科・分野横断的な科目における授業実践を行った。最初の試みとして，気象・季節・気候および植物との関連が重要となる理科の教科内容をベースに，学際的な側面を持ついくつかのテーマが見出された。とりわけ，生物季節（フェノロジー）は，ESD に関連した気象・気候の季節サイクルと植物の成長および環境応答との関わりに関する学生の理解を促進するうえで有用であることが，授業分析から示唆された。これらの授業実践から，気象学と植物学との連携が，自然環境系の ESD 的理解の促進のみならず，教科内容構成の分野横断的な検討にも役立ち，教師教育のためのアプローチとして有望である可能性が示された。Practical lessons for liberal arts in university aimed at education for sustainable development (ESD)-oriented understanding of the natural environmental systems were conducted through collaboration between meteorological and botanical scientific studies. As the first trial, some interdisciplinary themes were identified, based on subject contents in science education in which the relationship between weather/seasons/climate and plants is important. In particular, an analysis of the lesson, “Seasons and plants”, revealed that phenology was helpful in enhancing students’ understanding of the relationship between the seasonal cycle of weather/climate and plant growth and responses to the environment associated with ESD. These practical lessons proved that collaboration between meteorology and botany is valuable for both the promotion of ESD-oriented understanding of the natural environmental systems and cross-cutting consideration of the subject content in science education, providing a promising approach for teacher education

Resonant tunneling of Hydrogen in Pd

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High-fidelity conversion of photonic quantum information to telecommunication wavelength with superconducting single-photon detectors

We experimentally demonstrate a high-fidelity visible-to-telecommunication wavelength conversion of a photon by using a solid-state-based difference frequency generation. In the experiment, one half of a pico-second visible entangled photon pair at 780 nm is converted to a 1522-nm photon, resulting in the entangled photon pair between 780 nm and 1522 nm. Using superconducting single-photon detectors with low dark count rates and small timing jitters, we selectively observed well-defined temporal modes containing the two photons. We achieved a fidelity of $0.93 \pm 0.04$ after the wavelength conversion, indicating that our solid-state-based scheme can be used for faithful frequency down-conversion of visible photons emitted from quantum memories composed of various media.Comment: 5 pages, 4 figure

Cancer Immunol Immunother

Purpose Through genome-wide expression profile analysis, hypoxia-inducible protein 2 (HIG2) has previously been identified as an oncoprotein involved in development/progression of renal cell carcinoma (RCC). We subsequently identified a highly immunogenic HLA-A*0201/0206-restricted epitope peptide (HIG2-9-4) corresponding to a part of HIG2 and applied it as a therapeutic vaccine. We conducted a phase I clinical trial using the HIG2-9-4 peptide for patients with advanced RCC. Materials and Methods Nine patients having HLA-A*0201 or HLA-A*0206 with metastatic or unresectable RCC after failure of the cytokine and/or tyrosine kinase inhibitor therapies were enrolled in this study. The patients received subcutaneous administration of the peptide as an emulsion form with Montanide ISA-51 VG once a week in a dose-escalation manner (doses of 0.5, 1.0, or 3.0 mg/body, 3 patients for each dose). The primary endpoint was safety, and the secondary endpoints were immunological and clinical responses. Results Vaccinations with HIG2-9-4 peptide could be well tolerated without any serious systemic adverse events. Peptide-specific cytotoxic T lymphocyte (CTL) responses were detected in eight of the nine patients. Doses of 1.0 or 3.0 mg/body seemed to induce a CTL response better than did a dose of 0.5 mg/body, although the number of patients was too small to draw a firm conclusion. The disease control rate (stable disease for ≥4 months) was 77.8 %, and the median progression-free survival time was 10.3 months. Conclusions HIG2-9-4 peptide vaccine treatment was tolerable and effectively induced peptide-specific CTLs in RCC patients. This novel peptide vaccine therapy for RCC is promising

Sulfate transporters involved in sulfate secretion in the kidney are localized in the renal proximal tubule II of the elephant fish (Callorhinchus milii)

Most vertebrates, including cartilaginous fishes, maintain their plasma SO4 (2-) concentration ([SO4 (2-)]) within a narrow range of 0.2-1 mM. As seawater has a [SO4 (2-)] about 40 times higher than that of the plasma, SO4 (2-) excretion is the major role of kidneys in marine teleost fishes. It has been suggested that cartilaginous fishes also excrete excess SO4 (2-) via the kidney. However, little is known about the underlying mechanisms for SO4 (2-) transport in cartilaginous fish, largely due to the extraordinarily elaborate four-loop configuration of the nephron, which consists of at least 10 morphologically distinguishable segments. In the present study, we determined cDNA sequences from the kidney of holocephalan elephant fish (Callorhinchus milii) that encoded solute carrier family 26 member 1 (Slc26a1) and member 6 (Slc26a6), which are SO4 (2-) transporters that are expressed in mammalian and teleost kidneys. Elephant fish Slc26a1 (cmSlc26a1) and cmSlc26a6 mRNAs were coexpressed in the proximal II (PII) segment of the nephron, which comprises the second loop in the sinus zone. Functional analyses using Xenopus oocytes and the results of immunohistochemistry revealed that cmSlc26a1 is a basolaterally located electroneutral SO4 (2-) transporter, while cmSlc26a6 is an apically located, electrogenic Cl(-)/SO4 (2-) exchanger. In addition, we found that both cmSlc26a1 and cmSlc26a6 were abundantly expressed in the kidney of embryos; SO4 (2-) was concentrated in a bladder-like structure of elephant fish embryos. Our results demonstrated that the PII segment of the nephron contributes to the secretion of excess SO4 (2-) by the kidney of elephant fish. Possible mechanisms for SO4 (2-) secretion in the PII segment are discussed