Thin film bonded to elastic orthotropic substrate under thermal loading

The problem of thin elastic films bonded on an elastic orthotropic substrate under thermal load is investigated in this work. Differently from past studies on the same topic, the effects induced by anisotropic behavior of the elastic substrate will be taken into account. Particular attention will also be paid to the determination of the displacement and stress fields induced by thermal loading. In particular, it is assumed that the thin films are deposed on the substrate at high temperature, and then the mismatch occurring during the cooling process, due to the difference between the thermal expansion coefficients of the two materials, is responsible for the permanent deformation assumed by the system. This phenomenon can be exploited for realizing a crystalline undulator. To this aim, the permanent deformation must be optimized in order to encourage the channeling phenomenon. By imposing equilibrium conditions and perfect adhesion between the film and the substrate, a singular integral equation is derived. A closed-form solution is achieved by expanding the interfacial shear stress fields in Chebyshev series. The unknown coefficients in the series expansion are then determined by transforming the integral equation into an infinite algebraic system

Pitt-Hopkins syndrome: report of a case with a TCF4 gene mutation

<p>Abstract</p> <p>Aims</p> <p>We will discuss the clinical and genetic diagnosis of a child with severe psychomotor delay, who at 3 years of age presented with paroxysms of hyperpnea-apnea and seizures unrelated to breathing anomalies.</p> <p>Methods</p> <p>The child underwent genetic (karyotype, FISH telomeres) and neuroradiological (cranial CT and MRI) tests, which proved to be normal. He came under our clinical observation at 3 years and 5 months of age. Due to severe psychomotor delay and facial dysmorphisms we completed the genetic investigations based on his clinical feature and analysis of the available literature.</p> <p>Results</p> <p>The presence of severe mental retardation associated with anomalous breathing pattern may suggest the Joubert and Rett syndrome, however these were excluded on the basis of clinical and genetic examination. Angelman syndrome, suspected for facial dysmorphisms and absent language, was also excluded because of the presence of a normal pattern of methylation at SNRPN locus. Another possible diagnosis was the Pitt-Hopkins Syndrome (PHS), characterized by severe mental retardation, breathing anomalies (paroxisms of hyperpnea-apnea), dysmorphisms and sometimes epilepsy. Haploinsufficiency of TCF4 gene located at 18q21.2 region has been recently identified as causative of this syndrome. In our patient the research of TCF4 mutation by the Institute of Human Genetics, University Hospital Erlangen (Germany), showed a de novo mutation.</p> <p>Conclusions</p> <p>The diagnosis of Pitt-Hopkins syndrome, an underdiagnosed cause of mental retardation, was based on clinical and genetic findings. Searching for TCF4 mutations is highly recommended when others overlapping syndromes was excluded. At our knowledge our patient is the first italian case of PHS diagnosed at molecular level.</p

Electromagnetic sensors for underwater scour monitoring

Scour jeopardises the safety of many civil engineering structures with foundations in riverbeds and it is the leading cause for the collapse of bridges worldwide. Current approaches for bridge scour risk management rely mainly on visual inspections, which provide unreliable estimates of scour and of its effects, also considering the difficulties in visually monitoring the riverbed erosion around submerged foundations. Thus, there is a need to introduce systems capable of continuously monitoring the evolution of scour at bridge foundations, even during extreme flood events. This paper illustrates the development and deployment of a scour monitoring system consisting of smart probes equipped with electromagnetic sensors. This is the first application of this type of sensing probes to a real case-study for continuous scour monitoring. Designed to observe changes in the permittivity of the medium around bridge foundations, the sensors allow for detection of scour depths and the assessment of whether the scour hole has been refilled. The monitoring system was installed on the A76 200 Bridge in New Cumnock (S-W Scotland) and has provided a continuous recording of the scour for nearly two years. The scour data registered after a peak flood event (validated against actual measurements of scour during a bridge inspection) show the potential of the technology in providing continuous scour measures, even during extreme flood events, thus avoiding the deployment of divers for underwater examination

IMPlementing split Regimen OVEr Single dose using a Plan-Do-Study-Act approach (IMPROVES study)

Background and aims A split-dose regimen for colonoscopy is recommended by international guidelines, but its adoption is still suboptimal. Our aim was to assess whether a Plan-Do-Study-Act approach (PDSA), a scientific method promoting quality improvement, would be able to improve adherence to a split-dose regimen, and to identify factors influencing its adoption. Methods This study consisted of three phases: Cycle 1: a cross-sectional assessment of split-dose adherence in consecutive outpatients/inpatients undergoing colonoscopies in 74 Italian centers; Educational intervention: regional meetings with literature review, analysis of Cycle 1 data, and discussion on corrective measures; local diffusion of educational material and tools for improvement; Cycle 2: reassessment of split-dose adherence after spontaneous local interventions. Demographic, clinical, and procedural variables were systematically collected. Multivariate logistic regression was used to identify predictors of split-dose adoption. Results In total, 8213 patients (mean age = 60.29 years (SD = 13.58), men = 54 %, outpatients = 88.4 %) were enrolled between 2013 and 2016 (Cycle 1 = 4189 patients and Cycle 2 = 4024 patients). Split-dose adoption rose from 29.1 % in Cycle 1 to 51.1 % in Cycle 2 ( P &lt; 0.0001), and being enrolled in Cycle 2 independently predicted split-dose adherence (OR = 2.9; 95 %CI 2.6 - 3.3). The adoption improved in all time slots, including colonoscopies scheduled before 0930. The main corrective measures were: rescheduling of colonoscopies after 0930 (between 0930 and 1130: OR = 2.6; 95 %CI 2.3 - 3.1; after 1130: OR = 7; 95 %CI 5.9 - 8.4); the cleansing regimen communicated by the Endoscopy unit (via form: OR = 1.6; 95 %CI 1.3 - 1.9; via visit: OR = 2.1; 95 %CI 1.7 - 2.5); a decrease in the use of deep sedation (OR = 2; 95 %CI 1.7 - 2.5). Conclusions An educational intervention with observation-driven corrections through a PDSA approach was able to substantially increase the adoption of a split-dose regimen

Standard Model updates and new physics analysis with the Unitarity Triangle fit

We present here the update of the Unitarity Triangle (UT) analysis performed by the UTfit Collaboration within the Standard Model (SM) and beyond. Continuously updated flavour results contribute to improving the precision of several constraints and through the global fit of the CKM parameters and the SM predictions. We also extend the UT analysis to investigate new physics (NP) effects on $\Delta F=2$ processes. Finally, based on the NP constraints, we derive upper bounds on the coefficients of the most general $\Delta F=2$ effective Hamiltonian. These upper bounds can be translated into lower bounds on the scale of NP that contributes to these low-energy effective interactions.Comment: Proceedings of the 8th International Workshop on the CKM Unitarity Triangle (CKM 2014), Vienna, Austria, September 8-12, 201

Management of hydrocele in adolescent patients

Hydrocele is defined as an abnormal collection of serous fluid in the potential space between the parietal and visceral layers of the tunica vaginalis. In the majority of affected adolescents, hydrocele is acquired and is idiopathic in origin. The pathogenesis of idiopathic hydrocele is thought to be an imbalance in the normal process of fluid production and reabsorption. The diagnosis is usually clinical. Taking a thorough history is essential to rule out any fluctuation in size, which is an indication of a patent processus vaginalis. Scrotal ultrasonography is mandatory in nonpalpable testicles to rule out a subtending testicular solid mass requiring inguinal exploration. Otherwise, open hydrocelectomy via a scrotal incision is the standard treatment of idiopathic hydroceles. The second most common cause of hydrocele in adolescents is varicocelectomy. The risk of hydrocele formation is higher with non-artery-sparing procedures or those performed without microsurgical aid, and in surgery requiring cord dissection. If hydrocele occurs after varicocelectomy, initial management should include observation with or without hydrocele aspiration. Large persistent hydroceles are best served by open hydrocelectomy

Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID-19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS-CoV-2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut-off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID-19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk

A Qualitative Exploration of the Use of Contraband Cell Phones in Secured Facilities

Offenders accepting contraband cell phones in secured facilities violate state corrections law, and the possession of these cell phones is a form of risk taking behavior. When offenders continue this risky behavior, it affects their decision making in other domains where they are challenging authorities; and may impact the length of their incarceration. This qualitative phenomenological study examined the lived experience of ex-offenders who had contraband cell phones in secured correctional facilities in order to better understand their reasons for taking risks with contraband cell phones. The theoretical foundation for this study was Trimpop\u27s risk-homeostasis and risk-motivation theories that suggest an individual\u27s behaviors adapt to negotiate between perceived risk and desired risk in order to achieve satisfaction. The research question explored beliefs and perceptions of ex-offenders who chose to accept the risk of using contraband cell phones during their time in secured facilities. Data were collected anonymously through recorded telephone interviews with 8 male adult ex-offenders and analyzed using thematic content analysis. Findings indicated participants felt empowered by possession of cell phones in prison, and it was an acceptable risk to stay connected to family out of concern for loved ones. The study contributes to social change by providing those justice system administrators, and prison managers responsible for prison cell phone policies with more detailed information about the motivations and perspectives of offenders in respect to using contraband cell phones while imprisoned in secured facilities

Combining Interior Orientation Variables to Predict the Accuracy of Rpas–Sfm 3D Models

Remotely piloted aerial systems (RPAS) have been recognized as an effective low-cost tool to acquire photogrammetric data of low accessible areas reducing collection and processing time. Data processing techniques like structure from motion (SfM) and multiview stereo (MVS) techniques, can nowadays provide detailed 3D models with an accuracy comparable to the one generated by other conventional approaches. Accuracy of RPAS-based measures is strongly dependent on the type of adopted sensors. Nevertheless, up to now, no investigation was done about relationships between camera calibration parameters and final accuracy of measures. In this work, authors tried to fill this gap by exploring those dependencies with the aim of proposing a prediction function able to quantify the potential final error in respect of camera parameters. Predictive functions were estimated by combining multivariate and linear statistical techniques. Four photogrammetric RPAS acquisitions were considered, supported by ground surveys, to calibrate the predictive model while a further acquisition was used to test and validate it. Results are preliminary, but promising. The calibrated predictive functions relating camera internal orientation (I.O.) parameters with final accuracy of measures (root mean squared error) showed high reliability and accuracy