Suggested Practices for Making I-O Connections: Let’s Build Bridges and Grow I-O!

It may come as no surprise, but there are an awful lot of people who have no idea what I-O pychology is or what I-O psychologists do. Common reactions from new acquaintances include, “Ooo, I could really use some help organizing my home and be a more industrious person” or “Wow, that’s a mouthful” or “No really, what do you do for a living?” Perhaps even more alarming is the number of students across universities who aren’t introduced to I-O—even if they are psychology majors! We are struck by the number of prospective graduate students who tell us that they wouldn’t know that I-O existed had it not been for a chance encounter with an I-O psychologist. For every one of these talented young people who join the field, there are 10 more who don’t have that chance encounter and end up in a different field

(E)-1-(6-Chloro-2-methyl-4-phenyl-3-quinol­yl)-3-(4-ethoxy­phen­yl)prop-2-en-1-one

In the title compound, C27H22ClNO2, the phenyl substituent on the quinoline ring system is almost perpendicular to it [dihedral angle = 88.2 (1)°]. The quinoline ring system and the ethoxy­phenyl ring are oriented at dihedral angles of 79.5 (1) and 17.6 (3)°, respectively, with respect to the almost planar [r.m.s. deviation= 0.037 (3) Å] –C(=O)—C=C– linkage. In the crystal, the inversion-related mol­ecules exist as C—H⋯O hydrogen-bonded R 2 2(8) dimers

4-{2-[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]thia­zol-4-yl}benzonitrile

The asymmetric unit of the title compound, C25H14ClFN4S, contains two independent mol­ecules (A and B). Each mol­ecule consists of five rings, namely chloro­phenyl, fluoro­phenyl, 1H-pyrazole, thia­zole and benzonitrile. In mol­ecule A, the 1H-pyrazole ring makes dihedral angles of 52.54 (8), 35.96 (8) and 15.43 (8)° with respect to the attached chloro­phenyl, fluoro­phenyl and thia­zole rings. The corresponding values in mol­ecule B are 51.65 (8), 37.26 (8) and 8.32 (8)°. In the crystal, mol­ecules are linked into dimers by C—H⋯N hydrogen bonds, generating R 2 2(10) ring motifs. These dimers are further linked into two-dimensional arrays parallel to the ab plane via inter­molecular weak C—H⋯N and C—H⋯F hydrogen bonds. The crystal structure is further stabilized by weak π-π inter­actions [with centroid–centroid distances of 3.4303 (9) and 3.6826 (9) Å] and weak C—H⋯π inter­actions

4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-ethyl­piperazine-1-carboxamide

The asymmetric unit of the title compound, C23H23ClFN5O2, contains two crystallographically independent mol­ecules. In one mol­ecule, the pyrazole ring makes dihedral angles of 43.93 (7) and 35.82 (7)°, respectively, with the fluoro- and chloro-substituted benzene rings, while the corresponding angles in the other mol­ecule are 52.26 (8) and 36.85 (7)°. The piperazine rings adopt chair conformations. In the crystal, adjacent mol­ecules are connected via inter­molecular N—H⋯O, C—H⋯F, C—H⋯N and C—H⋯O hydrogen bonds, forming a two-dimensional network parallel to the bc plane. The crystal structure is further stabilized by a weak π–π inter­action with a centroid–centroid distance of 3.6610 (8) Å and by C—H⋯π inter­actions

(2E,6E)-2,6-Bis(2,4,5-trimethoxy­benzyl­idene)cyclo­hexa­none

In the title compound, C26H30O7, one atom in the cyclo­hexa­none ring is disordered over two positions with a site-occupancy ratio of 0.871 (6):0.129 (6). The dihedral angles formed between the mean plane through the six C atoms of the major component of the cyclo­hexa­none ring and two benzene rings are 35.09 (10) and 34.21 (10)°; the corresponding angles for the minor component are 20.1 (2) and 19.5 (2)°. Both the major and minor disordered components of the cyclo­hexa­none ring adopt half-boat conformations. In the crystal packing, inter­molecular C—H⋯O hydrogen bonds connect the mol­ecules into a three-dimensional network

3-Acetyl-6-chloro-2-methyl-4-phenyl­quinolinium perchlorate

In the title mol­ecular salt, C18H15ClNO+·ClO4 −, the quinolin­ium ring system is approximately planar, with a maximum deviation of 0.027 (1) Å. The dihedral angle formed between the mean planes of the quinolinium ring system and the benzene ring is 78.46 (3)°. In the crystal structure, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the cations and anions into a three-dimensional network. The crystal structure is further consolidated by C—H⋯π inter­actions

4-Methyl-5-phenyl-1H-pyrazol-3-ol

The title compound, C10H10N2O, crystallizes with two independent mol­ecules in the asymmetric unit, having closely comparable geometries. The dihedral angles between the 1H-pyrazole and benzene rings in the two mol­ecules are 39.57 (14) and 41.95 (13)°. The two mol­ecules are each connected to neighbouring mol­ecules by pairs of inter­molecular O—H⋯N hydrogen bonds, forming dimers with R 2 2(8) ring motifs. These dimers are further linked into R 4 4(10) ring motifs by inter­molecular N—H⋯O hydrogen bonds, forming chains along [101]. The crystal structure is further stabilized by a C—H⋯π inter­action

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

Acknowledgements This work was supported by the Wellcome Trust (203128/Z/16/Z, 110126/Z/ 15/Z, and 106898/A/15/Z) and the Medical Research Council UK (MR/ K01207X/2). TE Sutherland was supported by Medical Research Founda- tion UK joint funding with Asthma UK (MRFAUK-2015-302). We thank Andrew McKenzie (Cambridge) for providing the Il13 tm3.1Anjm mice. We further thank the Flow Cytometry, Bioimaging, Genomic Technologies, BioMS, and Bio- logical Services core facilities at the University of Manchester.Peer reviewedPublisher PD

Molecular Epidemiology of Anthrax Cases Associated with Recreational Use of Animal Hides and Yarn in the United States

To determine potential links between the clinical isolate to animal products and their geographic origin, we genotyped (MLVA-8, MVLA-15, and canSNP analysis) 80 environmental and 12 clinical isolates and 2 clinical specimens from five cases of anthrax (California in 1976 [n = 1], New York in 2006 [n = 1], Connecticut in 2007 [n = 2], and New Hampshire in 2009[n = 1]) resulting from recreational handling of animal products. For the California case, four clinical isolates were identified as MLVA-8 genotype (GT) 76 and in the canSNP A.Br.Vollum lineage, which is consistent with the Pakistani origin of the yarn. Twenty eight of the California isolates were in the A.Br.Vollum canSNP lineage and one isolate was in the A.Br. 003/004 canSNP sub-group. All 52 isolates and both clinical specimens related to the New York and Connecticut cases were MLVA-8 GT 1. The animal products associated with the NY and CT cases were believed to originate from West Africa, but no isolates from this region are available to be genotyped for comparison. All isolates associated with the New Hampshire case were identical and had a new genotype (GT 149). Isolates from the NY, CT and NH cases diverge from the established canSNP phylogeny near the base of the A.Br.011/009. This report illustrates the power of the current genotyping methods and the dramatically different epidemiological conditions that can lead to infections (i.e., contamination by a single genotype versus widespread contamination of numerous genotypes). These cases illustrate the need to acquire and genotype global isolates so that accurate assignments can be made about isolate origins