On the thermal conduction in tangled magnetic fields in clusters of galaxies

Thermal conduction in tangled magnetic fields is reduced because heat conducting electrons must travel along the field lines longer distances between hot and cold regions of space than if there were no fields. We consider the case when the tangled magnetic field has a weak homogeneous component. We examine two simple models for temperature in clusters of galaxies: a time-independent model and a time-dependent one. We find that the actual value of the effective thermal conductivity in tangled magnetic fields depends on how it is defined for a particular astrophysical problem. Our final conclusion is that the heat conduction never totally suppressed but is usually important in the central regions of galaxy clusters, and therefore, it should not be neglected.Comment: 16 pages, 4 figure

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures.

Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmental exposures in complex diseases. However, detailed molecular events that result in epigenetic changes following exposures remain unclear. Here, we review the emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating these processes. Targeting TET1 and its associated pathways may have therapeutic potential in alleviating negative impacts of environmental exposures, preventing and treating exposure-related diseases

Interacting Multiple Model-Feedback Particle Filter for Stochastic Hybrid Systems

In this paper, a novel feedback control-based particle filter algorithm for the continuous-time stochastic hybrid system estimation problem is presented. This particle filter is referred to as the interacting multiple model-feedback particle filter (IMM-FPF), and is based on the recently developed feedback particle filter. The IMM-FPF is comprised of a series of parallel FPFs, one for each discrete mode, and an exact filter recursion for the mode association probability. The proposed IMM-FPF represents a generalization of the Kalmanfilter based IMM algorithm to the general nonlinear filtering problem. The remarkable conclusion of this paper is that the IMM-FPF algorithm retains the innovation error-based feedback structure even for the nonlinear problem. The interaction/merging process is also handled via a control-based approach. The theoretical results are illustrated with the aid of a numerical example problem for a maneuvering target tracking application

Radio Frequency Interference Mitigation

Radio astronomy observational facilities are under constant upgradation and development to achieve better capabilities including increasing the time and frequency resolutions of the recorded data, and increasing the receiving and recording bandwidth. As only a limited spectrum resource has been allocated to radio astronomy by the International Telecommunication Union, this results in the radio observational instrumentation being inevitably exposed to undesirable radio frequency interference (RFI) signals which originate mainly from terrestrial human activity and are becoming stronger with time. RFIs degrade the quality of astronomical data and even lead to data loss. The impact of RFIs on scientific outcome is becoming progressively difficult to manage. In this article, we motivate the requirement for RFI mitigation, and review the RFI characteristics, mitigation techniques and strategies. Mitigation strategies adopted at some representative observatories, telescopes and arrays are also introduced. We also discuss and present advantages and shortcomings of the four classes of RFI mitigation strategies, applicable at the connected causal stages: preventive, pre-detection, pre-correlation and post-correlation. The proper identification and flagging of RFI is key to the reduction of data loss and improvement in data quality, and is also the ultimate goal of developing RFI mitigation techniques. This can be achieved through a strategy involving a combination of the discussed techniques in stages. Recent advances in high speed digital signal processing and high performance computing allow for performing RFI excision of large data volumes generated from large telescopes or arrays in both real time and offline modes, aiding the proposed strategy.Comment: 26 pages, 10 figures, Chinese version accepted for publication in Acta Astronomica Sinica; English version to appear in Chinese Astronomy and Astrophysic

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

Drug nanosuspensions/nanocrystals have been recognized as one useful and successful approach for drug delivery. Drug nanocrystals could be further decorated to possess extended functions (such as controlled release) and designed for special in vivo applications (such as drug tracking), which make best use of the advantages of drug nanocrystals. A lot of novel and advanced size reduction methods have been invented recently for special drug deliveries. In addition, some novel downstream processes have been combined with nanosuspensions, which have highly broadened its application areas (such as targeting) besides traditional routes. A large number of recent research publication regarding as nanocrystals focuses on above mentioned aspects, which have widely attracted attention. This review will focus on the recent development of nanocrystals and give an overview of regarding modification of nanocrystal by some new approaches for tailor-made drug delivery

Theory of time-resolved spectral function in high-temperature superconductors with bosonic modes

We develop a three-temperature model to simulate the time dependence of electron and phonon temperatures in high-temperature superconductors displaying strong anistropic electron-phonon coupling. This model not only takes the tight-binding band structure into account, but also is valid in superconducting state. Based on this model, we calculate the time-resolved spectral function via the double-time Green's functions. We find that the dip-hump structure evolves with the time delay. More interestingly, new phononic structures are obtained when the phonons are excited by a laser field. This signature may serve as a direct evidence for electron-vibration mode coupling.Comment: 5 pages, 3 figure