The New England boarding school : an analysis of its historical development and contemporary uncertainty of purpose.

This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#337 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3)

PER2::LUC Imaging Mouse#375

This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#375 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3)

Behavioral Data - Actograms

This file contains activity records for the in vivo phenotyping phase of this study. To view, it is best to open them with Clocklab software

PER2::LUC Imaging Mouse#362

This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#362 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3)

PER2::LUC Imaging Mouse#372

This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#372 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3)

PER2::LUC Imaging Mouse#360

This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#360 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3)

Comparison of cell parameters.

<p>Parameters are defined in the caption to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033334#pone-0033334-t001" target="_blank">Table 1</a>, with correlation coefficients given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033334#pone-0033334-t002" target="_blank">Table 2</a>. Greater amplitude tends to be associated with reduced variability, and variability in period tends to be much less than that in amplitude.</p

PER2::LUC Imaging Mouse#380

This file contains a tiff sequence for PER2::LUC imagign data from SCN slices collected from Mouse#380 (rostral SCN = Slice1, middle SCN = Slice2, caudal SCN = Slice3)

Correlations among fibroblast parameters, as defined in Table 1.

<p>Pearson correlation coefficients were calculated; Spearman correlation coefficients gave very similar results.</p

Stochastic modeling.

<p>(A) Results from fitting the fibroblast data to the stochastic model, as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033334#s4" target="_blank">Methods</a>. Fit values with the parameter <i>s</i><1 indicate that the oscillations are noise-induced (the deterministic system would be steady state), while fit values with <i>s</i>≥1 indicate that the oscillations are self-sustained. (B) Results of simulations of the stochastic model for different values of the parameter s, fixing the amplitude of <i>z</i> to be 500 molecules (by adjusting the value of Ω with respect to <i>s</i>). The mean value of the period CV over 500 simulations is shown for each value of <i>s</i>. The period CV is minimized for <i>s</i> in the range 1.1–1.2. (C) Example of a stochastic simulation with <i>s</i> = 1.03, where Ω is chosen so that the amplitude of <i>z</i> is 500 molecules. The period CV for this simulation is 0.073.</p