Main Thought of al Muhasibi in the Book al Masail fi A'mal al-Qulub wa al-Jawarih fi al Makasib wa al-Aql

Al-Muhasibi was a phenomenal figure in the VIII-IX centuries who mastered several disciplines, especially fiqh and al-hadith as well as Sufism.  Al-Muhasibi was born in Iraq in 781 AD (165 AH). His thoughts in the field of Sufism can be found in several of his monumental works, among others, in ar-Risalah lil Huquqillah, al-Washoya aw an-Nashoih, Risalah al-Mustarsyidin, al-Masail fi A'mal al Qulub wa al-Jawarih wa al-  Makasib wa al-Aql and Fi Fahm al Qur'an (understanding the Koran). The book of al-Masail fi A'mal al-Qulub wa al-jawarih fi al-Makasib wa-al-Aql by al-Muhasibi essentially leads to spiritual education so that people are clean in mind, have a clear heart and sincerely seek forgiveness and love of Allah in their activities. The Methode used in this paper is qualitative  content analysis. This book explaned about zuhud and keeping the body as good as possible to achieve the mercy and blessing from the God the almighty.  al Muhasibi explained that people who have simple ideals will cause that person to have positive activities and always be zuhud in spending their assets.  This is because, he is afraid that his property will be lost so that he cannot spend it according to Allah's command. al-Muhasibi's thoughts in his book al Masail fi A'mal al-Qulub wa al-jawarih fi al Makasib Wa al-Aql to be used as a qudwah (model) for human behavior.  The behavior referred to here is both in the context of human interaction in the vertical dimension, namely interacting with God (Allah), as well as in the horizontal application level, namely human interaction with other humans

Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model

Objective: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. Methods: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg). Two weeks after bilaterally ovariectomy, OA was induced by intra-articular injection of monosodium iodoacetate into the right knee joints. After 28 days of treatment, the rats were evaluated for knee OA via physical (radiological and histological observations), biochemical, enzyme-linked immunosorbent assay, and gene expression analysis, for inflammation and cartilage degradation biomarkers. Results: The osteoarthritic rats treated with the extract, and diclofenac showed significant reduction of cartilage erosion (via radiological, macroscopic, and histological images) compared with untreated osteoarthritic rats. The elevated serum interleukin-1β, prostaglandin E2, and C-telopeptide type II collagen levels in osteoarthritic rats were significantly reduced by F deltoidea leaf extract comparable to diclofenac. The extract significantly down-regulated the interleukin-1β, prostaglandin E2 receptor, and matrix metalloproteinase-1 mRNA expressions in the osteoarthritic cartilages, similar to diclofenac. Conclusions: F deltoidea leaf extract mitigated postmenopausal osteoarthritic joint destruction by inhibiting inflammation and cartilage degradation enzymes, at an effective extract dose equivalent to about 60 mg/kg for humans. The main bioactive compounds are probably the antioxidative flavonoids vitexin and isovitexin

KONSEP PENDIDIKAN AKHLAK DALAM AL-QUR`AN SURAT AL-AN’AM AYAT 151 PADA ERA GLOBALISASI

Pendidikan akhlak berperan penting dalam membentuk generasi Islam yang berkarakter di era globalisasi. Konsep pendidikan akhlak dalam agama Islam bisa dijumpai dalam Al Quran dan sunnah, sebagai rujukan utama umat muslim. Fokus dalam penelitian adalah konsep pendidikan akhlak yang terdapat dalam Al Quran surat Al-An’am ayat 151. Pada penelitian ini bertujuan untuk menguraikan konsep pendidikan akhlak yang terkandung dalam surat Al-An’am ayat 151 dan keterkaitannya dengan era globalisasi. Jenis penelitian yang digunakan yaitu penelitian library research. Persoalan akhlak menjadi hal yang sangat penting untuk dikaji. Apalagi melihat kondisi kehidupan semakin dinamis di era globalisasi sekarang ini. Konsep  pendidikan akhlak yang tercantum dalam surat Al An’am ayat 151 antara lain beriman kepada Allah (ketauhidan), kasih sayang (termasuk berbakti pada orangtua dan kasih sayang kepada anak)., tanggung jawab dan cinta damai

Rancang Bangun e-HRM (electronic Human Resources Management) (Studi Kasus : Kantor Pusat Pos Keadilan Peduli Umat)

Lembaga Pos Keadilan Peduli Ummat (PKPU) adalah sebuah lembaga yang bergerak di bidang kemanusiaan, berkomitmen dalam penerimaan dan penyaluran Zakat, Infaq dan Sedekah (ZIS) bagi umat islam yang memang berhak menerima di Indonesia. Lembaga PKPU menyadari kualitas sistem sumber daya manusia yang dimiliki lembaga tentunya dapat secara langsung mempengaruhi kualitas dan kelangsungan bisnis perusahaan. Pada saat ini sistem yang mengatur sumber daya manusia yang berjalan pada lembaga PKPU adalah sistem terkomputerisasi yang menggunakan aplikasi Microsoft Office dalam mengolah data karyawan dan data administrasi karyawan seperti pengolahan data perekrutan, pelatihan, cuti, perpindahan, pengunduran diri dan pensiun dimana mengharuskan setiap data yang masuk menggunakan banyak kertas, sehingga terjadinya pemborosan hard copydan tidak jarang data tersebut menjadi tercecer bahkan sampai hilang sehingga akan sulit mencarinya apabila dibutuhkan kembali. Selain itu pada proses pelatihan tidak jarang mengalami tidak tersebar dan tidak tepatnya informasi mengenai pelatihan.Untuk itu perlu adanya pembenahan terhadap pengaturan sistem sumber daya manusia. Hal ini memberikan inisiatif untuk membangun sistem electronic Human Resources Management (e-HRM) sebagai inovasi HRM berbasis web untuk menangani masalah tersebut. Dalam penelitian ini menggunakan metode pengembangan sistem Rapid Application Development(RAD). Perancangan sistem dilakukan dengan notasi Unified Modeling Language (UML) use case diagram, activity diagram, sequence diagram, dan class diagram. Hasil penelitian ini menghasilkan rancang bangun e-HRM yang dapat menyimpan data karyawan dan data administrasi seperti data perekrutan, pelatihan, cuti, perpindahan, pengunduran diri dan pensiun yang tersimpan dalam databasesehingga dapat memudahkan pengolahan, pencarian, dan pelaporan data

Konsep Pendidikan Akhlak dalam Al-qur`an Surat Al-an'am Ayat 151 pada Era Globalisasi

Pendidikan akhlak berperan penting dalam membentuk generasi Islam yang berkarakter di era globalisasi. Konsep pendidikan akhlak dalam agama Islam bisa dijumpai dalam Al Quran dan sunnah, sebagai rujukan utama umat muslim. Fokus dalam penelitian adalah konsep pendidikan akhlak yang terdapat dalam Al Quran surat Al-An'am ayat 151. Pada penelitian ini bertujuan untuk menguraikan konsep pendidikan akhlak yang terkandung dalam surat Al-An'am ayat 151 dan keterkaitannya dengan era globalisasi. Jenis penelitian yang digunakan yaitu penelitian library research. Persoalan akhlak menjadi hal yang sangat penting untuk dikaji. Apalagi melihat kondisi kehidupan semakin dinamis di era globalisasi sekarang ini. Konsep  pendidikan akhlak yang tercantum dalam surat Al An'am ayat 151 antara lain beriman kepada Allah (ketauhidan), kasih sayang (termasuk berbakti pada orangtua dan kasih sayang kepada anak)., tanggung jawab dan cinta damai

Evaluation of Clinacanthus nutans(Burm. f.) Lindau and Ficus deltoidea leaf extracts for cartilage and bone marrow health in experimental rat osteoarthritis

Medicinal plants have been used to treat various ailments including in osteoarthritis (OA) for decades. Currently, the existing drugs for treating OA only alleviate symptoms and improve the joint function, but cannot treat cartilage and bone damage. Developing therapeutics from plant-derived sources may exert less negative side effects, compared to the use of common non-streroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis. Hereby, the present study investigated the effect of Clinacanthus nutans (belalai gajah) and Ficus deltoidea (mas cotek), compared with diclofenac, on cartilage and bone marrow health on experimental OA model. In preliminary in vitro bovine cartilage explant culture, the recombinant bovine IL-1β of 10 ng/mL was added to the cartilage explants in DMEM/F12 media to induce OA condition. CN or FD leaf extracts at 20, 40, and 80 μg/mL, or diclofenac at 5 μg/mL, were simultaneously added into the medium after IL-1β induction. The amount of proteoglycan loss, reactive oxygen species (ROS) produced, and chondrocytes morphology were evaluated. In in vivo experiment, 42 12-week-old Sprague Dawley female rats were randomized into seven groups (n=7). The rats were subjected to bilateral ovariectomy (OVX) and OA was induced by intra-articular injection of monosodium iodoacetate (MIA) at 60 mg/mL into right knee joints, excluding healthy group. Healthy and OA non-treated groups were given deionized water while treatment groups were orally treated with 200 or 400 mg/kg body weight of CN or FD leaf extracts or 5 mg/kg body weight of diclofenac once a day for 28 days. Serum levels of inflammation including interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and prostaglandin E2 (PGE2); cartilage catabolic including matrix metalloproteinase 1 (MMP-1), matrix metalloproteinase 13 (MMP-13), C-terminal cross-linked telopeptide of type II collagen (CTX-II), and N-terminal propeptide of collagen type II (PIINP); and bone turnover markers including osteoprotegerin, osteocalcin, receptor activator of nuclear kappa-beta ligand (RANKL), and C-terminal crosslinked telopeptide type I collagen (CTX-I) were assessed by enzyme-linked immunosorbent assay (ELISA). Articular cartilage changes were determined by radiological, macroscopic, and histological observations. Gene expressions of inflammatory including nuclear factor kappa beta (NF-κβ), interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), cyclooxygenase 2 (COX-2), and prostaglandin E2 (PGE2); and cartilage catabolic mediators including matrix metalloproteinase 1 (MMP-1), matrix metalloproteinase 13 (MMP-13), A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), and A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) were determined to study the mechanisms involved. Bone turnover regulations were evaluated via bone mass density, dimension, biomechanics, and microarchitecture. Flavones of apigenin derivatives including vitexin, isovitexin, schaftoside, and isoschaftoside were identified in both CN and FD leaf extracts. Preliminary in vitro study showed chondroprotective effects of CN and FD leaf extracts and diclofenac by significantly inhibiting proteoglycan loss, ROS production, and preventing chondrocytes apoptosis. In in vivo study, CN and FD leaf extracts possessed cartilage and bone protecting nature by significantly suppressing the augmented activities of inflammatory (IL-1β, IL-6, and PGE2), and cartilage catabolic (MMP-1 and MMP-13) serum levels comparable to diclofenac. The osteoarthritic rats treated with the extracts and diclofenac showed significant reduction of cartilage erosion via radiological, macroscopic and histological images, compared to untreated osteoarthritic rats. The extracts significantly down-regulated NF-κβ, IL-1β, TNF-α, IL-6, PGE2, MMP-1, and MMP-13 expressions in the osteoarthritic cartilage similar to diclofenac. Furthermore, CN and FD leaf extracts administration protected bone marrow by significantly increased bone volume ratio, decreased trabecular separation, and decreased total porosity of the bone marrow. These findings were supported by bone turnover markers; which the extracts significantly increased bone formation (osteoprotegerin and osteocalcin) and reduced bone resorption (CTX-I and RANKL) markers, comparable to diclofenac. Overall, CN and FD leaf extracts were demonstrated to be a potent agent mitigating cartilage and bone loss in OA. The results achieved were at least as good than those with diclofenac, a widely used NSAID and a benchmark pharmacological treatment for OA. The main bioactive compounds are probably responsible for anti-inflammatory and antioxidant properties in the protection of cartilage and bone marrow in OA