The problem of juvenile delinquency in relation to Christian education in the home

https://place.asburyseminary.edu/ecommonsatsdissertations/2304/thumbnail.jp

Zespedes and the Southern Conspiracies

The peace treaty by which the American colonists gained their independence in 1783 created a situation along their southern border almost designed, it seemed, to provoke hostility. By the treaty, the provinces of East and West Florida, which had belonged to Britain for the previous twenty years and had remained loyal to the Crown, were returned to Spain. Thus Europe’s oldest colonial power regained a foothold on the southeastern seaboard of North America, but now was threatened by an ambitious young republic - the first independent nation in the western hemisphere. Furthermore, a portion of the border remained in dispute until 1796. The controversy between the two governments concerned the northern limit of West Florida, from the Mississippi River to the source of the St. Mary’s River, which was the northern border of East Florida

The 1789 Saint Augustine Celebration

One of the most elaborate celebrations of Saint Augustine’s colonial history occurred in December, 1789, when the civilian and military populations joined in honoring Charles IV’S ascension to the Spanish throne. Parades, theatricals, religious services and soirees with dancing till dawn were features of the three day festival beginning the afternoon of December 2

Dissolution and Mechanical properties of Bioresorbable Glass Fibres for use in Paediatric tracheal stents

Stents provide biological support in body conduits and are useful for counteracting stenosis (constriction) in cardiovascular, gastrointestinal, uretheral and airway passages1. However, the current widespread use of permanent metal stents that remain throughout the lifespan of a patient, threaten restenosis, thrombosis, or physical irritation if not surgically removed. In infants the clinical requirement is for a stent that retains structural integrity for periods of several weeks up to many months in vivo during host tissue restoration2 and from a materials perspective this requires an implant with appropriate mechanical and degradation characteristics. Bioresorbable phosphate glass fibres have shown enormous potential for temporary implants and tissue repair, owing to their mechanical properties and solubility in aqueous media which can be modified by addition of various oxide compounds3,4. Further, when combined with degradable polymers the resulting glass fibre polymer composites (GFRP) become ductile allowing them to be forged into supporting scaffolds with suitable mechanical and dissolution properties. To date however, their use for stenting applications has not been investigated possibly due to major difficulties of processing these compositions into fibre form. In this study, two phosphate glass fibre compositions containing SiO2 (silica) and B2O3 (Boron) were fabricated to test the hypothesis that B2O3 containing phosphate glass fibres present enhanced mechanical and dissolution behaviour for use as a degradable stent

Development and application of the direct mycobacterial growth inhibition assay: a systematic review

Introduction: First described by Wallis et al. in 2001 for the assessment of TB drugs, the direct mycobacterial growth inhibition assay (MGIA) offers a tractable ex vivo tool measuring the combined influences of host immunity, strain virulence and intervention effects. Over the past 13 years, we have led efforts to adapt the direct MGIA for the assessment of TB vaccines including optimisation, harmonisation and validation of BCG vaccine-induced responses as a benchmark, as well as assay transfer to institutes worldwide. Methods: We have performed a systematic review on the primary published literature describing the development and applications of the direct MGIA from 2001 to June 2023 in accordance with the PRISMA reporting guidelines. Results: We describe 63 studies in which the direct MGIA has been applied across species for the evaluation of TB drugs and novel TB vaccine candidates, the study of clinical cohorts including those with comorbidities, and to further understanding of potential immune correlates of protection from TB. We provide a comprehensive update on progress of the assay since its conception and critically evaluate current findings and evidence supporting its utility, highlighting priorities for future directions. Discussion: While further standardisation and validation work is required, significant advancements have been made in the past two decades. The direct MGIA provides a potentially valuable tool for the early evaluation of TB drug and vaccine candidates, clinical cohorts, and immune mechanisms of mycobacterial control. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42023423491

Controlling schistosomiasis: the cost-effectiveness of alternative delivery strategies

Sustainable schistosomiasis control cannot be based on large-scale vertical treatment strategies in most endemic countries, yet little is known about the costs and effectiveness of more affordable options. This paper presents calculations of the cost-effectiveness of two forms of chemotherapy targeted at schoolchildren and compares them with chemotherapy integrated into the routine activities of the primary health care system. The focus is on Schistosoma haematobium. Economic and epidemiological data are taken from the Kilombero District of Tanzania. The paper also develops a framework for possible use by programme managers to evaluate similar options in different epidemiological settings. The results suggest that all three options are more affordable and sustainable than the vertical strategies for which cost data are available in the literature. Passive testing and treatment through primary health facilities proved the most effective and cost-effective option given the screening and compliance rates observed in the Kilombero Distric

Evaluation of the Adult Learning Grant cohort 2 (wave 1)

"The Centre for Research in Social Policy (CRSP) at Loughborough University and the National Centre for Social Research (NatCen) are evaluating ALG on behalf of the Department for Education and Skills and the National Office of the Learning and Skills Council... The Adult Learning Grant (ALG) aims to support adults who have not yet obtained their first Level 2 or first Level 3 qualification. The ALG is intended to help adults with the additional costs of learning (for example, books, travel) through the provision of a means-tested monetary grant." - pp. i-ii

Evaluation of the Adult Learning Grant cohort 1 (waves 1 and 2)

"The Adult Learning Grant (ALG) was announced as part of the Government’s Skills Strategy in 2003. The ALG pilot began in September 2003 in ten areas across England. The ALG aims to support adults in learning through the offer of a meanstested monetary allowance... Throughout the report (except for ALG experiences), [this] analysis focuses on comparisons between ALG applicants (or sub-groups: awardees or recipients) and qualification-eligible non-applicants." -- pp. i & iii

Recreational Use of Acidic Pit Lakes—Human Health Considerations for Post Closure Planning

Pit lakes may form in mining voids that extend below groundwater level after mining ceases and many have been found to have elevated metals concentrations and low pH through acidic and metalliferous drainage (AMD). Pit lakes are often used for recreational activities including swimming, fishing and boating and poor water quality may present health risks to recreational users. Pit lakes also provide the opportunity for additional water resource uses. The Collie Coal Basin in south-western Australia currently has a number of pit lakes with moderate AMD effects which are also used for recreational pursuits. Twelve hundred questionnaires were mailed to selected addresses in the Collie shire with an additional 170 questionnaires to specific interest groups. Participants were asked about the type of activity, frequency and duration and any health symptoms experienced after use of the lakes. Two hundred and fifty questionnaires were returned, which comprised 176 returns from the random sample and 74 from the targeted sample. Three pit lakes with elevated metals concentrations and low pH were used for recreational purposes by 62% of respondents. This was mostly in summer with swimming the most common activity. Of all respondents 52% were concerned about lake water quality and 38% using the lakes reported a variety of symptoms. Recreational use of Collie pit lakes did not represent a health risk for most of the surveyed population due to the low frequency and duration of use, however health risks may be elevated in sensitive users such as children and those consuming seafood from the lakes. Comprehensive water quality monitoring for chemicals and further characterisation of recreational use of pit lakes is warranted to more comprehensively assess the potential health risks to recreational users. Post closure mine plans need to consider potential future community uses combined with assessments of water quality and physical characteristics to reduce the potential for adverse health and safety impacts