The Volume Fraction of Ionized Intergalactic Gas at Redshift z=6.5

The observed number density of Lyman-alpha sources implies a minimum volume of the inter-galactic medium that must be ionized, in order to allow the Lyman-alpha photons to escape attenuation. We estimate this volume by assigning to each Lyman-alpha emitter the minimum Stromgren sphere that would allow half its Lyman-alpha photons to escape. This implies a lower limit to ionized gas volume fraction of 20-50% at redshift z=6.5. This is a lower limit in two ways: First, we conservatively assume that the Lyman-alpha sources seen (at a relatively bright flux limit) are the only ones present; and second, we assume the smallest Stromgren sphere volume that will allow the photons to escape. This limit is completely independent of what ionizing photon sources produced the bubbles. Deeper Lyman-alpha surveys are possible with present technology, and can strengthen these limits by detecting a higher density of Lyman-alpha galaxies.Comment: Submitted to ApJ Letter

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and signal transducer and activator of transcription 3 (STAT3) stimulate colorectal cancer development and progression via cell autonomous and microenvironmental effects. Using a unique inhibitor, NT157, which targets both IGF-1 receptor (IGF-1R) and STAT3, we show that these pathways regulate many TME functions associated with sporadic colonic tumorigenesis in CPC-APC mice, in which cancer development is driven by loss of the Apc tumor suppressor gene. NT157 causes a substantial reduction in tumor burden by affecting cancer cells, cancer-associated fibroblasts (CAF) and myeloid cells. Decreased cancer cell proliferation and increased apoptosis were accompanied by inhibition of CAF activation and decreased inflammation. Furthermore, NT157 inhibited expression of pro-tumorigenic cytokines, chemokines and growth factors, including IL-6, IL-11 and IL-23 as well as CCL2, CCL5, CXCL7, CXCL5, ICAM1 and TGFβ; decreased cancer cell migratory activity and reduced their proliferation in the liver. NT157 represents a new class of anti-cancer drugs that affect both the malignant cell and its supportive microenvironment

Grain Survival in Supernova Remnants and Herbig-Haro Objects

By using the flux ratio [FeII]8617/[OI]6300, we demonstrate that most of the interstellar dust grains survive in shocks associated with supernova remnants and Herbig-Haro objects. The [FeII]/[OI] flux ratio is sensitive to the gas-phase Fe/O abundance ratio, but is insensitive to the ionization state, temperature, and density of the gas. We calculate the [FeII]/[OI] flux ratio in shocks, and compare the results with the observational data. When only 20% of iron is in the gas phase, the models reproduce most successfully the observations. This finding is in conflict with the current consensus that shocks destroy almost all the grains and 100% of metals are in the gas phase. We comment on previous works on grain destruction, and discuss why grains are not destroyed in shocks.Comment: 8 pages (AASTex v5.0), 3 figures. To be published in ApJ Letters (accepted 3/10/2000

Intermediate-mass-ratio-inspirals in the Einstein Telescope: I. Signal-to-noise ratio calculations

The Einstein Telescope (ET) is a proposed third generation ground-based interferometer, for which the target is a sensitivity that is a factor of ten better than Advanced LIGO and a frequency range that extends down to about 1Hz. ET will provide opportunities to test Einstein's theory of relativity in the strong field and will realize precision gravitational wave astronomy with a thousandfold increase in the expected number of events over the advanced ground-based detectors. A design study for ET is currently underway, so it is timely to assess the science that could be done with such an instrument. This paper is the first in a series that will carry out a detailed study of intermediate-mass-ratio inspirals (IMRIs) for ET. In the context of ET, an IMRI is the inspiral of a neutron star or stellar-mass black hole into an intermediate mass black hole (IMBH). In this paper we focus on the development of IMRI waveform models for circular and equatorial inspirals. We consider two approximations for the waveforms, which both incorporate the inspiral, merger and ringdown phases in a consistent way. One approximation, valid for IMBHs of arbitrary spin, uses the transition model of Ori and Thorne [1] to describe the merger, and this is then matched smoothly onto a ringdown waveform. The second approximation uses the Effective One Body (EOB) approach to model the merger phase of the waveform and is valid for non-spinning IMBHs. In this paper, we use both waveform models to compute signal-to-noise ratios (SNRs) for IMRI sources detectable by ET. At a redshift of z=1, we find typical SNRs for IMRI systems with masses 1.4+100 solar masses, 10+100 solar masses, 1.4+500 solar masses and 10+500 solar masses of about 10-25, 40-80, 3-15 and 10-60, respectively. We also find that the two models make predictions for non-spinning inspirals that are consistent to about ten percent.Comment: 27 pages, 9 figures, v3 has an updated reference for consistency with accepted versio

Carbon nanotube quantum dots on hexagonal boron nitride

We report the fabrication details and low-temperature characteristics of the first carbon nanotube (CNT) quantum dots on flakes of hexagonal boron nitride (hBN) as substrate. We demonstrate that CNTs can be grown on hBN by standard chemical vapor deposition and that standard scanning electron microscopy imaging and lithography can be employed to fabricate nanoelectronic structures when using optimized parameters. This proof of concept paves the way to more complex devices on hBN, with more predictable and reproducible characteristics and electronic stability.Comment: 4 pages, 4 figure