広域的統治組織のガバナンスに関する一考察 : 国の出先機関の受け皿としての「九州広域行政機構」のあり方を中心に

道州制についてはこれまで国の将来像として様々な提言や答申が行われてきたが、地域主権戦略大綱で国の出先機関の原則廃止が明言されたことから、より具体的な広域行政組織に関する制度設計が議論されるようになった。九州地方知事会からは九州広域行政機構が提案され、国の３つの出先機関を「丸ごと」引き受ける受け皿機関が議論の対象となっている。この制度設計にあたっては、将来のあるべき姿に至るプロセスとしていろいろな選択肢が考えられる。急進的な改革案は実現可能性の観点から多くの課題に阻まれて容易に成案をなさないが、ダイナミックな政治力学の中で政策の方向性を見失わないようにするためには、まずあるべき姿を明確にすることが重要である。これまでの道州制の議論をベースに、現在進行中の立法過程に関連して、具体的な受け皿機関のガバナンスに関する立法論的考察を行う

Detailed and high-throughput measurement of composition dependence of magnetoresistance and spin-transfer torque using a composition-gradient film: application to Cox_{x}Fe1−x_{1-x} (0 ≤\le x\textit{x} ≤\le 1) system

We develop a high-throughput method for measuring the composition dependence of magnetoresistance (MR) and spin-transfer-torque (STT) effects in current-perpendicular-to-plane giant magnetoresistance (CPP-GMR) devices and report its application to the CoFe system. The method is based on the use of composition-gradient films deposited by combinatorial sputtering. This structure allows the fabrication of devices with different compositions on a single substrate, drastically enhancing the throughput in investigating composition dependence. We fabricated CPP-GMR devices on a single GMR film consisting of a Co$_{x}$Fe$_{1-x}$ (0 $\le$ $\textit{x}$ $\le$ 1) composition-gradient layer, a Cu spacer layer, and a NiFe layer. The MR ratio obtained from resistance-field measurements exhibited the maximum in the broad Co concentration range of 0.3 $\le$ $\textit{x}$ $\le$ 0.65. In addition, the STT efficiency was estimated from the current to induce magnetization reversal of the NiFe layer by spin injection from the Co$_{x}$Fe$_{1-x}$ layer. The STT efficiency was also the highest around the same Co concentration range as for the MR ratio, and this correlation was theoretically explained by the change in the spin polarization of the Co$_{x}$Fe$_{1-x}$ layer. The results revealed the Co$_{x}$Fe$_{1-x}$ composition range suitable for spintronic applications, demonstrating the advantages of the developed method.Comment: 19 pages, 5 figure

Anomalous momentum dependence of the multiband electronic structure of FeSe_1-xTe_x superconductors induced by atomic disorder

When periodicity of crystal is disturbed by atomic disorder, its electronic state becomes inhomogeneous and band dispersion is obscured. In case of Fe-based superconductors, disorder of chalcogen/pnictogen height causes disorder of Fe 3d level splitting. Here, we report an angle-resolved photoemission spectroscopy study on FeSe_1-xTe_x with the chalcogen height disorder, showing that the disorder affects the Fe 3d band dispersions in an orbital-selective way instead of simple obscuring effect. The reverse of the Fe 3d level splitting due to the chalcogen height difference causes the splitting of the hole band with Fe 3d x^2-y^2 character around the Gamma point.Comment: 5 pages, 4 figure

Sheet Dependence on Superconducting Gap in Oxygen-Deficient Iron-based Oxypnictide Superconductors NdFeAs0.85

Photoemission spectroscopy with low-energy tunable photons on oxygen-deficient iron-based oxypnictide superconductors NdFeAsO0.85 (Tc=52K) reveals a distinct photon-energy dependence of the electronic structure near the Fermi level (EF). A clear shift of the leading-edge can be observed in the superconducting states with 9.5 eV photons, while a clear Fermi cutoff with little leading-edge shift can be observed with 6.0 eV photons. The results are indicative of the superconducting gap opening not on the hole-like ones around Gamma (0,0) point but on the electron-like sheets around M(pi,pi) point.Comment: 8 pages, 3 figure

Autopsy Case of Bilateral Optic Nerve Aplasia with Microphthalmia: Neural Retina Formation Is Required for the Coordinated Development of Ocular Tissues

Human congenital anomalies provide information that contributes to the understanding of developmental mechanisms. Here we report bilateral optic nerve aplasia (ONA) with microphthalmia in the autopsy of the cadaver of a 70-year-old Japanese female. The gross anatomical inspection of the brain showed a cotton thread-like cord in the presumed location of the optic nerve tract or chiasm. Histologically, no neural retina, optic nerve bundle or retinal central vessels were formed in the eye globe, and the retinal pigment cells formed rosettes. The cornea, iris, and lens were also histologically abnormal. Immunohistochemically, no retinal cells expressed beta III tubulin, and Pax6-immunoreactive cells were present in the ciliary non-pigmented epithelial cells. This case of ONA could be attributed to the agenesis of retinal projection neurons as a sequel to the disruption of neural retina development. The neural retina formation would coordinate the proper development of ocular tissues

Zirconia Implants with Laser Surface Treatment: Peri-Implant Bone Response and Enhancement of Osseointegration

The aim of this study was to prepare zirconia implants with laser-modified surfaces and to evaluate peri-implant tissue response and osseointegration in an animal study. The experimental zirconia implants received one of the following surface treatments and were placed in the tibiae of SD rats: vertical irradiation with a fiber laser (vertical fiber laser), horizontal irradiation with a fiber laser (horizontal fiber laser), vertical irradiation with a Neodymium-doped yttrium orthovanadate (YVO4) laser (vertical YVO4 laser), and horizontal irradiation with a YVO4 laser (horizontal YVO4 laser). The control implants were smooth surfaced. Tibiae with implant bodies were collected 28 days after implant placement, and removal torque values were measured. Tissue sections were prepared for light microscopy, and the bone-implant contact (BIC) ratio and the peri-implant bone area (BA) were measured. The vertical fiber-laser implants had a mean BIC that was significantly higher than other implants. The mean BIC of the vertical fiber-laser implants was approximately 4.2 folds of the value of the control implants on the cortical bone side and approximately 2.7 folds of the value of the control implants on the bone marrow side. The mean BA was significantly higher in the vertical YVO4-laser implants. The vertical fiber-laser implants had a mean torque removal value that was approximately 2.4 folds of the value of the control implants and approximately double of the value of the vertical or horizontal YVO4-laser implants. The horizontal fiber-laser implants had a mean removal torque value that was approximately double of the value of the control implants and approximately 1.7 folds of the value of the vertical or horizontal YVO4-laser implants (p<0.05). Both types of lasers were useful in implant surface treatment to enhance osseointegration of zirconia implants.福岡歯科大学2013年

Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line

AbstractHeparin-binding EGF-like growth factor (HB-EGF) is a recently identified potent mitogen for smooth muscle cells and fibroblasts. HB-EGF has been shown to be an EGF receptor ligand, and also to stimulate epithelial cell growth. A human hepatoma-derived cell line, Mahlavu, was analyzed for the production of HB-EGF mRNA and active HB-EGF protein. It was found that the cell line synthesized very low or undetectable basal level of HB-EGF mRNA. However, the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) led to a rapid and transient rise in HB-EGF mRNA level. HB-EGF in Mahlavu cells appears to be regulated by a protein kinase C (PKC) pathway, since PKC inhibitors, H7, staurosporin, and calphostin C, abrogated the induction of HB-EGF mRNA by TPA. Unlike vascular smooth muscle cells, induction of HB-EGF gene transcription by TPA was blocked completely by incubation with cycloheximide, suggesting that protein synthesis may be a prerequisite for HB-EGF gene transcription in Mahlavu cells. Mahlavu cells were also found to release a bioactive HB-EGF-like protein into conditioned medium which stimulates DNA synthesis in EP170.7 cells. This activity was neutralized by an anti-HB-EGF antibody. These results indicate that HB-EGF gene transcription is regulated via a PKC pathway, resulting in secretion of active HB-EGF into the culture medium of hepatoma-derived Mahlavu cells