Effect of Ti-Si mixed oxide support on gold catalysts for gas-phase epoxidation of propylene

Titania-silica mixed oxides prepared by hydrolytic and one-step non-hydrolytic sol-gel routes using TICl4 and SiCl4 as precursors were employed as the gold catalyst supports for gas-phase epoxiclation of propylene in O-2 and H-2. Characterization studies of the supports and catalysts were performed by means of X-ray diffraction, ultraviolet-visible absorption spectroscopy, N-2 adsorption, and high-resolution transmission electron microscopy. The results indicated that the amorphous Ti-Si mixed oxides containing 6%-14% of Ti could be prepared by both sol-gel routes, but those by non-hydrolytic sol-gel afforded higher surface area and significant mesopores. A superior catalytic performance was obtained with the gold catalyst supported on the non-hydrolytic sol-gel Ti-Si mixed oxide containing 10% of Ti. The propylene conversion was 5.7% at the initial 60 min and 3.3% at 240 min of time on stream. The selectivity for propylene oxide was as high as 95%. The influences of aging time for the non-hydrolytic sol-gel and pH value for the Au deposition-precipitation on the performance of the Au catalyst were also discussed

Honeycomb-Patterned Hybrid Films and Their Template Applications via A Tunable Amphiphilic Block Polymer/Inorganic Precursor System

通讯作者地址: Li,L(通讯作者),Xiamen Univ,Coll Mat, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China 2. Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 3. Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 电子邮件地址: [email protected], we show a facile and versatile method-prepare highly ordered inorganic patterns on solid substrates by pyrolyzing UV cross-linked polymr/functional. precursor hybrid films. The crosslinked polymer matrix acted as structure-directing agent in a pyrolyzing process, whereas the functional precursor was converted into the skeleton of the micropatterns. The inorganic micropatterns could be further catalytically functionalized to grow CNT and ZnO nanorod arrays by simply changing different functional precursors. This simple technique offers new prospects in the field of micropatterns, nanolithography, and template.National Natural Science Foundation of China,50703032,20974089;Natural Science Foundation of Fujian Province,2009J06029; Ministry of Education of Chin

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10−13), ALDH2/MYL2 (rs671, P = 3.40 × 10−11; rs12229654, P = 4.56 × 10−9), ITIH4 (rs2535633, P = 1.77 × 10−10) and NT5C2 (rs11191580, P = 3.83 × 10−8) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10−8) and an additional 14 at P < 1.0 × 10−3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity

Superior Performance of Gold Supported on Titanium-Containing Hexagonal Mesoporous Molecular Sieves for Gas-Phase Epoxidation of Propylene with Use of H-2 and O-2

Titanium-containing hexagonal mesoporous silicas (Ti-HMS) with wormhole structure and Si/Ti molar ratios ranging from 10 to 40 have been prepared by using long-chain alkyl primary amines as template agents. The Ti-HMS supported Au catalyst (Au/Ti-HMS) was obtained by a deposition-precipitation method for direct gas-phase epoxidation of propylene with use of O-2 and H-2. The structures of Ti-HMS and Au/Ti-HMS samples were characterized by X-ray diffraction, N-2-physisorption, scanning electron microscopy, transmission electron microscopy, UV-vis diffuse reflectance spectroscopy, UV Raman spectroscopy, ammonia-temperature-programmed desorption, and atomic adsorption spectroscopy. The results showed that the Au/Ti-HMS catalyst exhibited superior performance in terms of propylene conversion, propylene oxide (PO) selectivity, and H-2 efficiency in comparison with the Au catalysts supported on the conventional Ti-containing mesoporous materials. Besides the Si/Ti molar ratio, the chain length of alkylamine for the Ti-HMS preparation was crucial for the enhancement of catalytic performance. Specifically, 9.0% of propylene conversion, 97.3% of PO selectivity, and 30.4% of H efficiency can be obtained at 373 K in the initial 30 min of time-on-stream on the Au/Ti-HMS catalyst, where the Ti-HMS having a Si/Ti molar ratio at 20 was prepared by using tetradecylamine as the template agent. Regeneration of the spent catalyst by calcination in air gave almost no change in the PO selectivity but about 25% loss in the propylene conversion. The enhanced catalytic performance of Au/Ti-HMS catalyst may be essentially attributed to the homogeneous dispersion and uniformity of titanium species in combination with accessible pore structure.NSFC [20433030, 20873108, 20423002]; NSF of Fujian Province [2007J0013]; Doctoral Program of Higher Education [20050384011]; Chinese Ministry of Education [106099]; [2009CB939804

Ti-Si mixed oxides by non-hydrolytic sol-gel synthesis as potential gold catalyst supports for gas-phase epoxidation of propylene in H-2 and O-2

The amorphous Ti-Si mixed oxides prepared from chloride precursors using a one-step nonhydrolytic sol-gel route could serve as efficient gold catalyst supports for gas-phase epoxidation of propylene in O-2 and H-2. A propylene conversion of 6.8% at the initial 60 min and 4.0% after 4 h of time-on-steam, keeping a selectivity to propylene oxide as high as 95%, was obtained over the gold supported on a Ti-Si mixed oxide containing 10 mol % of Ti

Association of body mass index with cause specific deaths in Chinese elderly hypertensive patients: Minhang community study.

BACKGROUND: Most studies have suggested that elevated body mass index (BMI) was associated with the risk of death from all cause and from specific causes. However, there was little evidence illustrating the effect of BMI on the mortality in elderly hypertensive patients in Chinese population. METHODS: The information of 10,957 hypertensive patients at baseline not less than 60 years were from Xinzhuang, a town in Minhang district of Shanghai, was extracted from the Electronic Health Record (EHR) system. All study participants were divided into eight categories of baseline BMI (with cut-points at 18, 20, 22, 24, 26, 28 and 30 kg/m(2)). Relative hazard ratio of death from all cause, cardiovascular and non-cardiovascular cause by baseline BMI groups were calculated, standardized for sex, age, smoking, drinking, physical activity, systolic blood pressure, history of cardiovascular disorders, serum lipid disturbance, diabetes mellitus and antihypertensive drug treatment. RESULTS: DURING FOLLOW UP (MEDIAN: 3.7 years), 561 deaths occurred. Underweight (BMI<18 kg/m(2)) was associated with significantly increased mortality from all cause mortality (OR: 2.00; 95% CI: 1.43-2.79) and non cardiovascular mortality (OR: 2.76; 95% CI: 1.87-4.07), but not with cardiovascular mortality. For the cause specific analysis, the underweight was associated significantly with neoplasms (OR: 2.15; 95% CI: 1.16-4.00) and respiratory disorders (OR: 3.41; 95% CI: 1.64-7.06). The results for total mortality and specific cause mortality were not influenced by sex, age and smoking status. CONCLUSION: Our study revealed an association between underweight and increased mortality from non-cardiovascular disorders in elderly hypertensive patients in Chinese community. Overweight and obesity were not associated with all cause or cause specific death

Association of ATP2B1 common variants with asymptomatic intracranial and extracranial large artery stenosis in hypertension patients

Background and aims: Genetic factors play an important role in the cervico-cerebral large-artery atherosclerotic stenosis (LAS), and ATP2B1 gene has been associated with the process of atherosclerosis disorders, such as coronary artery disease and arterial stiffness. But there is little information about the relationship between ATP2B1 gene and atherosclerosis in the intracranial arteries. We hereby investigated the association of common variants in ATP2B1 gene with LAS in asymptomatic Chinese hypertension patients. Methods: The stenosis of intracranial and extracranial arteries were evaluated in 899 subjects through computerized tomography angiography from the aortic arch to the skull base. A total of 11 ATP2B1 common variants were genotyped. Multivariate logistic regression was carried out in a dominant model with confounding factors adjusted. Results: rs17249754-A (OR = 0.43, p = 0.0002) and rs1401982-G (OR = 0.47, p = 0.0007) were associated with decreased susceptibility of concurrent extra and intracranial stenosis even after Bonferroni correction. These two minor alleles were also significantly associated with less stenotic arteries and moderate-to-severe stenosis. Conclusion: rs17249754 and rs1401982 were associated with asymptomatic LAS in stroke-free Chinese hypertension patients and might benefit early recognition of LAS patients in clinical practice

Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.

Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (ECAS). Wehereby sought to explore the relationship of Lp-PLA2 and ICAS, ECAS and concurrent stenosis in stroke-free hypertensive patients in Chinese population.All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression.Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions.This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS

Predictive value of attended automated office blood pressure and resting pulse rate for mortality in community‐dwelling octogenarians: Minhang study

Systolic blood pressure (SBP) and resting pulse rate (RPR) have been linked to mortality and cardiovascular events in younger population. Till now, no studies simultaneously investigate the non‐linear association of SBP and RPR with all‐cause and cardiovascular mortality among population aged 80 and older. Data of 2828 eligible participants were selected from electronic health records linked attended automated office blood pressure measurement system. The dose‐response relationship between the SBP, RPR, and the risk of all‐cause and cardiovascular mortality was analyzed by Cox model with restricted cubic splines. During the 3.6‐year follow‐up, 442 deaths occurred. Comparing with the optimal SBP (117‐145 mmHg), the lower (HR: 1.39, 95% CI: 1.07‐1.81) and higher SBP (HR: 1.34, 95% CI: 1.08‐1.65) were significantly associated with an increasing risk of all‐cause mortality. The higher SBP (>144 mmHg) was associated with cardiovascular mortality, with the HR (95% CI) as 1.51 (1.07‐2.12). The faster RPR showed the higher risk of all‐cause (HR: 1.36, 95% CI: 1.05‐1.76) and cardiovascular (HR: 1.51, 95% CI: 1.07‐2.13) mortality. We found both higher SBP and faster RPR were independently associated with all‐cause and cardiovascular mortality, and lower SBP was only associated with the increased risk of all‐cause mortality in oldest old community‐dwelling Chinese population. Our results demonstrate the prognostic importance of both SBP and RPR in the elderly