N′-tert-Butyl-N′-(3,5-dimethyl­benzo­yl)-2,2-dimethyl-4-oxochroman-6-carbo­hydrazide

In the crystal structure of the title compound, C25H30N2O4, the steric size of the tert-butyl group causes the 3,5-dimethyl­phenyl ring to adopt a transoid geometry with respect to the N—C(O) bond. The six-membered heterocyclic ring is disordered over two sites, with occupancies of 0.553 (4) and 0.447 (4). Intra­molecular C—H⋯O inter­actions are present. In the crystal, mol­ecules are linked by inter­molecular N—H⋯O and C—H⋯O hydrogen bonds

N-qubit entanglement via the Jy2J_y^2-type collective interaction

We investigate quantum correlations of the $N$-qubit states via a collective pseudo-spin interaction ($\propto J_y^2$) on arbitrary pure separable states for a given interval of time. Based on this dynamical generation of the $N$-qubit maximal entangled states, a quantum secret sharing protocol with $N$ continuous classical secrets is developed.Comment: 12 pages, 3 figure

Prediction of the Lymph Node Status in Patients with Intrahepatic Cholangiocarcinoma: Analysis of 320 Surgical Cases

Purpose: This study was conducted to identify factors involved in lymph node metastasis (LNM) and evaluate their role in predicting LNM in clinically lymph node negative (clinical stage I–III) intrahepatic cholangiocarcinoma (ICC). Materials and Methods: We selected 320 patients who were diagnosed with ICC with no apparent clinical LNM (T1–3N0M0). Age, gender, tumor boundary, histological differentiation, tumor size, and carbohydrate antigen 19-9 value were the studied factors. Univariate and multivariate logistic analysis were conducted. Receiver operating characteristics curve analysis was used to test the predicting value of each factor and a test which combined the associated factors was used to predict LNM. Results: LNM was observed in 76 cases (76/320, 23.8%). Univariate and multivariate analysis showed that histological differentiation as well as tumor boundary and tumor size significantly correlated with LNM. The sensitivity and negative predictive value for LNM for the three factors when combined was 96.1 and 95% respectively. This means that 5% of the patients who did not have the risk factors mentioned above developed LNM. Conclusion: This model used the combination of three factors (low-graded histological differentiation, distinct tumor boundary, small tumor size) and they proved to be useful in predicting LNM in ICC with clinically lymph node negative cases. In patients with these criteria, lymph node dissection or lymph node irradiation may be omitted and such cases may also be good candidates for stereotactic body radiotherapy (SBRT)

Diaqua­bis­(1-methyl-1H-imidazole-κN 3)bis­[2-(naphthalen-1-yl)acetato-κO]cobalt(II)

In the title compound, [Co(C12H9O2)2(C4H6N2)2(H2O)2], the CoII ion is located on an inversion centre and displays a distorted octa­hedral coordination geometry. Two O atoms from two water mol­ecules and two carboxyl­ate O atoms from two 2-(naphthalen-1-yl)acetate ligands are in the equatorial plane and two N atoms from two 1-methyl-1H-imidazole ligands are in the axial positions. The structure is stabilized by intra­molecular O—H⋯O hydrogen bonds. Inter­molecular O—H⋯O hydrogen bonds link the complex mol­ecules into chains along [100]

Pyrrolidin-1-ium 2-(naphthalen-1-yl)acetate–2-(naphthalen-1-yl)acetic acid (1/1)

In the title compound, C4H10N+·C12H9O2 −·C12H10O2, the pyrrolidine ring adopts an envelope conformation and the dihedral angle between the planes of the two naphthalene ring systems is 8.34 (10)°. The crystal structure is stabilized by O—H⋯O and N—H⋯O hydrogen bonds

Bis(1H-benzimidazole-κN 3)bis­[2-(naphthalen-1-yl)acetato-κ2 O,O′]nickel(II) monohydrate

In the title compound, [Ni(C12H9O2)2(C7H6N2)2]·H2O, The NiII cation is located on a twofold rotation axis and is six-coordinated in a distorted NiN2O4 octa­hedral geometry. The asymmetric unit consists of a nickel(II) ion, one 2-(naphthalen-1-yl)acetate anion, a neutral benzotriazole ligand and one half of a lattice water mol­ecule. The crystal packing is stabilized by O—H⋯O and N—H⋯O hydrogen bonds. The title compound is isotypic with its CdII analogue

Effect of polysaccharide from the root of Bupleurum Chinese DC and Bupleurum scorzonerifolium Willd on hydrogen peroxide-induced myocardial apoptosis

Purpose: To investigate the protective effect of polysaccharide (BRP) from the root of Bupleurum Chinese DC. and Bupleurum scorzonerifolium Willd. on cardiomyocyte cells. Methods: Response surface methodology (RSM) based on Box-Behnken Design (BBD) was performed to optimize the extraction conditions for BRP. The effect of BRP on cardiomyocyte cell apoptosis was evaluated in H9c2 cells treated with hydrogen peroxide (H2O2). Cell viability was determined by CCK-8 assay, while oxidative stress levels in H9c2 cells, including lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT) and creatine kinase (CK) were determined using commercial kits following the manufacture’s instruction. mRNA expressions (caspase-3, caspase-8, caspase-9 and Fas) were determined by quantitative real time-polymerase chain reaction (RT-qPCR). Results: The obtained optimal extraction conditions for BRP was as follows: extraction time (1.43 h), ratio of water to the raw material (30 mL/g) and extraction times (2 times). BRP (200, 400, 600 and 800 μg/mL) significantly increased the cell viability of H2O2 induced H9c2 cells (p < 0.05, p < 0.01, p < 0.01, p < 0.01, respectively). BRP (200, 400 and 800 μg/mL) significantly decreased LDH and CK levels (p < 0.01, p < 0.01, p < 0.01, respectively). However, BRP increased levels of SOD (200, 400 and 800 μg/mL, p < 0.05) and CAT (400 and 800 μg/mL, p < 0.05) in H9c2 cells. BRP significantly downregulated mRNA expressions of Caspase-3, Caspase-8, Caspase-9 and Fas (200, 400 and 800 μg/mL, p < 0.01) in H9c2 cells induced by H2O2. Conclusion: BRP protects cardiomyocyte against apoptosis via inhibition of oxidative stress and mitochondria-mediated intrinsic apoptosis, and thus, may be potential therapeutic agent for the management of cardiovascular diseases. Keywords: Bupleurum Chinese, Bupleurum scorzonerifolium Willd., Polysaccharide, Cardiomyocyte, Apoptosis, H9c2 cell, Biochemical parameter