5′-Methyl­sulfanyl-4′-oxo-7′-phenyl-3′,4′-dihydro-1′H-spiro­[cyclo­hexane-1,2′-quinazoline]-8′-carbonitrile dimethyl­formamide monosolvate

In the title compound, C21H21N3OS·C3H7NO, the carbonitrile mol­ecule is built up of two fused six-membered rings and one six-membered ring linked through a spiro C atom. The 1,3-diaza ring adopts an envelope conformation and the cyclo­hexane ring adopts a chair conformation. The dihedral angle between the aromatic rings is 46.7 (3)°. In the crystal, the components are linked by N—H⋯O hydrogen bonds

Neural Semantic Parsing in Low-Resource Settings with Back-Translation and Meta-Learning

Neural semantic parsing has achieved impressive results in recent years, yet its success relies on the availability of large amounts of supervised data. Our goal is to learn a neural semantic parser when only prior knowledge about a limited number of simple rules is available, without access to either annotated programs or execution results. Our approach is initialized by rules, and improved in a back-translation paradigm using generated question-program pairs from the semantic parser and the question generator. A phrase table with frequent mapping patterns is automatically derived, also updated as training progresses, to measure the quality of generated instances. We train the model with model-agnostic meta-learning to guarantee the accuracy and stability on examples covered by rules, and meanwhile acquire the versatility to generalize well on examples uncovered by rules. Results on three benchmark datasets with different domains and programs show that our approach incrementally improves the accuracy. On WikiSQL, our best model is comparable to the SOTA system learned from denotations

Human Lens Phospholipid Changes with Age and Cataract

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Spiro­[cyclo­pentane-1,2′(1′H)-pyrido[2,3-d]pyrimidin]-4′(3′H)-one

The title compound, C11H13N2O, was obtained by cyclo­condensation of 2-amino­pyridine-3-carbonitrile with cyclo­penta­none. The mol­ecule is built up from two fused six-membered rings and one five-membered ring linked through a spiro C atom. Both the pyrimidine and the cyclo­pentane rings adopt envelope conformations. In the crystal structure, mol­ecules are linked by inter­molecular N—H⋯O hydrogen bonds