5,609 research outputs found
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Design of temperature insurance index and risk zonation for single-season rice in response to high-temperature and low-temperature damage: a case study of Jiangsu Province, China.
Disaster insurance is an important tool for achieving sustainable development in modern agriculture. However, in China, the design of such insurance indexes is far from sufïŹcient. In this paper, the single-season rice in Jiangsu Province of China is taken as an example to design the high-temperature damage index in summer and the low-temperature damage index in autumn to constructtheformulacalculatingtheweatheroutputandsingle-seasonriceyieldreduction. Thedaily highest, lowest and average temperatures between 1999 and 2015 are selected as main variables for the temperature disaster index to quantitatively analyze the relationship between the temperature indexandtheyieldreductionrateofthesingle-seasonrice. Thetemperaturedisasterindexcanbeput into the relevant model to obtain the yield reduction rate of the year and determine whether to pay the indemnity. Then, the burn analysis is used to determine the insurance premium rate for all cities in Jiangsu Province under four-level deductibles, and the insurance premium rate can be used for the risk division of the Province. The research provides some insights for the design of agricultural weather insurance products, and the empirical results provide a reference for the design of similar single-season rice temperature index insurance products
Inflammatory myofibroblastic tumor with extensive involvement of the bladder in an adolescent: a case report
Atomic force microscopy measurement of the Youngâs modulus and hardness of single LaB6 nanowires
We have employed the atomic force microscopy based (a) three-point bending and (b) nanoindentation methods to obtain the Youngâs modulus and hardness of single La B 6 nanowires. The Youngâs modulus, E = 467.1 ± 15.8 GPa , is the same as that of the La B 6 single crystals but larger than the sinteredpolycrystalline La B 6 samples. The nanoindentationhardness of the La B 6 nanowire is H = 70.6 ± 2.1 GPa at an indent depth of 4.6 nm , which is higher than that of the La B 6 single crystals, La B 6 polycrystals, and W metals. A superior resistance against thermal vibration, field modification, and ion bombardment is expected for the La B 6 nanowires as a field-emission point electron source
Dynamic Evolution of Eukaryotic Mitochondrial and Nuclear Genomes: A Case Study in the Gourmet Pine Mushroom Tricholoma matsutake
Fungi, as eukaryotic organisms, contain two genomes, the mitochondrial genome and the nuclear genome, in their cells. How the two genomes evolve and correlate to each other is debated. Herein, taking the gourmet pine mushroom Tricholoma matsutake as an example, we performed comparative mitogenomic analysis using samples collected from diverse locations and compared the evolution of the two genomes. The T. matsutake mitogenome encodes 49 genes and is rich of repetitive and non-coding DNAs. Six genes were invaded by up to 11 group I introns, with one cox1 intron cox1P372 showing presence/absence dynamics among different samples. Bioinformatic analyses suggested limited or no evidence of mitochondrial heteroplasmy. Interestingly, hundreds of mitochondrial DNA fragments were found in the nuclear genome, with several larger than 500 nt confirmed by PCR assays and read count comparisons, indicating clear evidence of transfer of mitochondrial DNA into the nuclear genome. Nuclear DNA of T. matsutake showed a higher mutation rate than mitochondrial DNA. Furthermore, we found evidence of incongruence between phylogenetic trees derived from mitogenome and nuclear DNA sequences. Together, our results reveal the dynamic genome evolution of the gourmet pine mushroom.Peer reviewe
Amelioration of Hypertriglyceridemia with Hypo-Alpha-Cholesterolemia in LPL Deficient Mice by Hematopoietic Cell-Derived LPL
BACKGROUND: Macrophage-derived lipoprotein lipase (LPL) has been shown uniformly to promote atherosclerotic lesion formation while the extent to which it affects plasma lipid and lipoprotein levels varies in wild-type and hypercholesterolemic mice. It is known that high levels of LPL in the bulk of adipose tissue and skeletal muscle would certainly mask the contribution of macrophage LPL to metabolism of plasma lipoprotein. Therefore, we chose LPL deficient (LPLâ»/â») mice with severe hypertriglyceridemia as an alternative model to assess the role of macrophage LPL in plasma lipoprotein metabolism via bone marrow transplant, through which LPL will be produced mainly by hematopoietic cell-derived macrophages. METHODS AND RESULTS: Hypertriglyceridemic LPLâ»/â» mice were lethally irradiated, then transplanted with bone marrow from wild-type (LPLâș/âș) or LPLâ»/â» mice, respectively. Sixteen weeks later, LPLâș/âș âLPLâ»/â» mice displayed significant reduction in plasma levels of triglyceride and cholesterol (408±44.9 vs. 2.7±0.5Ă10Âł and 82.9±7.1 vs. 229.1±30.6 mg/dl, p<0.05, respectively), while a 2.7-fold increase in plasma high density lipoprotein- cholesterol (p<0.01) was observed, compared with LPLâ»/â»âLPLâ»/â» control mice. The clearance rate for the oral fat load test in LPLâș/âș âLPLâ»/â» mice was faster than that in LPLâ»/â»âLPLâ»/â» mice, but slower than that in wild-type mice. Liver triglyceride content in LPLâș/âșâLPLâ»/â» mice was also significantly increased, compared with LPLâ»/â»âLPLâ»/â» mice (6.8±0.7 vs. 4.6±0.5 mg/g wet tissue, p<0.05, nâ=â6). However, no significant change was observed in the expression levels of genes involved in hepatic lipid metabolism between the two groups. CONCLUSIONS: Hematopoietic cell-derived LPL could efficiently ameliorate severe hypertriglyceridemia and hypo-alpha-cholesterolemia at the compensation of increased triglyceride content of liver in LPLâ»/â» mice
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria
Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from marine sediments (Pseudoalteromonas sp. strain CF6-2) can kill Gram-positive bacteria of diverse peptidoglycan (PG) chemotypes by secreting the metalloprotease pseudoalterin. Secretion of the enzyme requires a Type II secretion system. Pseudoalterin binds to the glycan strands of Gram positive bacterial PG and degrades the PG peptide chains, leading to cell death. The released nutrients, including PG-derived D-amino acids, can then be utilized by strain CF6-2 for growth. Pseudoalterin synthesis is induced by PG degradation products such as glycine and glycine-rich oligopeptides. Genes encoding putative pseudoalterin-like proteins are found in many other marine bacteria. This study reveals a new microbial interaction in the ocean
Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation
An efficient deadlock prevention approach for service oriented transaction processing
Transaction processing can guarantee the reliability of business applications. Locking resources is widely used in distributed transaction management (e.g., two phase commit, 2PC) to keep the system consistent. The locking mechanism, however, potentially results in various deadlocks. In service oriented architecture (SOA), the deadlock problem becomes even worse because multiple (sub)transactions try to lock shared resources in the unexpectable way due to the more randomicity of transaction requests, which has not been solved by existing research results. In this paper, we investigate how to prevent local deadlocks, caused by the resource competition among multiple sub-transactions of a global transaction, and global deadlocks from the competition among different global transactions. We propose a replication based approach to avoid the local deadlocks, and a timestamp based approach to significantly mitigate the global deadlocks. A general algorithm is designed for both local and global deadlock prevention. The experimental results demonstrate the effectiveness and efficiency of our deadlock prevention approach. Further, it is also proved that our approach provides higher system performance than traditional resource allocation schemes. © 2011 Elsevier Ltd. All rights reserved.link_to_subscribed_fulltex
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Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
Meiotic recombination creates genetic diversity and ensures segregation of homologous chromosomes. Previous population analyses yielded results averaged among individuals and affected by evolutionary pressures. We sequenced 99 sperm from an Asian male by using the newly developed amplification methodâmultiple annealing and looping-based amplification cyclesâto phase the personal genome and map recombination events at high resolution, which are nonuniformly distributed across the genome in the absence of selection pressure. The paucity of recombination near transcription start sites observed in individual sperm indicates that such a phenomenon is intrinsic to the molecular mechanism of meiosis. Interestingly, a decreased crossover frequency combined with an increase of autosomal aneuploidy is observable on a global per-sperm basis.Chemistry and Chemical Biolog
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Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction
Data availability statement: Data are available upon request from the corresponding authors.Copyright © 2022 The Authors. Aim: To investigate the directional and selective disconnection of the sensorimotor cortex (SMC) subregions in chronic stroke patients with hand dysfunction. Methods: We mapped the resting-state fMRI effective connectivity (EC) patterns for seven SMC subregions in each hemisphere of 65 chronic stroke patients and 40 healthy participants and correlated these patterns with paretic hand performance. Results: Compared with controls, patients demonstrated disrupted EC in the ipsilesional primary motor cortex_4p, ipsilesional primary somatosensory cortex_2 (PSC_2), and contralesional PSC_3a. Moreover, we found that EC values of the contralesional PSC_1 to contralesional precuneus, the ipsilesional inferior temporal gyrus to ipsilesional PSC_1, and the ipsilesional PSC_1 to contralesional postcentral gyrus were correlated with paretic hand performance across all patients. We further divided patients into partially (PPH) and completely (CPH) paretic hand subgroups. Compared with CPH patients, PPH patients demonstrated decreased EC in the ipsilesional premotor_6 and ipsilesional PSC_1. Interestingly, we found that paretic hand performance was positively correlated with seven sensorimotor circuits in PPH patients, while it was negatively correlated with five sensorimotor circuits in CPH patients. Conclusion: SMC neurocircuitry was selectively disrupted after chronic stroke and associated with diverse hand outcomes, which deepens the understanding of SMC reorganization.Natural Science Foundation of Zhejiang Province. Grant Number: LGF19H270001;
National Natural Science Foundation of China. Grant Number: 82002378;
China Postdoctoral Science Foundation. Grant Number: 2020M671726;
Shanghai Sailing Program. Grant Number: 20YF1445100
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