8 research outputs found

    New insights into the genetic etiology of Alzheimer's disease and related dementias

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    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele

    Comparing treatment methods that remove color from the effluent of an Organized Industrial District (OID)

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    This study investigates the treatability, in terms of color removal, of an effluent taken from an Organized Industrial District wastewater treatment plant located in Bursa, western Turkey. To remove the color, chemical coagulation, Fenton and Fenton-like oxidation, ozonation, adsorption, and membrane processes were employed, and the results were compared. In coagulation experiments, maximum color removal (87.4%) was obtained at pH 12.2 with a dose of 240 mg/L MgCl2 +Ca- (OH)(2). Fenton and Fenton-like oxidation processes showed high color removal efficiencies (93.1 and 80%, respectively) from the evaluated effluents. The best color removal (93.6%) in this study was achieved by an ozonation process at a dose of 8 g/L-min ozone with a pH of 12 and a contact time of 3 min. In addition to the color removal efficiencies for the applied processes, their associated operating costs were also calculated

    Role of A ÎČ Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease

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    Correlation between MDSC and Immune Tolerance in Transplantation: Cytokines, Pathways and Cell-cell Interaction

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