539 research outputs found
Classification in sparse, high dimensional environments applied to distributed systems failure prediction
Network failures are still one of the main causes of distributed systems’ lack of reliability. To overcome this problem we present an improvement over a failure prediction system, based on Elastic Net Logistic Regression and the application of rare events prediction techniques, able to work with sparse, high dimensional datasets. Specifically, we prove its stability, fine tune its hyperparameter and improve its industrial utility by showing that, with a slight change in dataset creation, it can also predict the location of a failure, a key asset when trying to take a proactive approach to failure management
Priority diffusion model in lattices and complex networks
We introduce a model for diffusion of two classes of particles ( and )
with priority: where both species are present in the same site the motion of
's takes precedence over that of 's. This describes realistic situations
in wireless and communication networks. In regular lattices the diffusion of
the two species is normal but the particles are significantly slower, due
to the presence of the particles. From the fraction of sites where the
particles can move freely, which we compute analytically, we derive the
diffusion coefficients of the two species. In heterogeneous networks the
fraction of sites where is free decreases exponentially with the degree of
the sites. This, coupled with accumulation of particles in high-degree nodes
leads to trapping of the low priority particles in scale-free networks.Comment: 5 pages, 3 figure
Spacings of Quarkonium Levels with the Same Principal Quantum Number
The spacings between bound-state levels of the Schr\"odinger equation with
the same principal quantum number but orbital angular momenta
differing by unity are found to be nearly equal for a wide range of power
potentials , with . Semiclassical approximations are in accord with this behavior. The
result is applied to estimates of masses for quarkonium levels which have not
yet been observed, including the 2P states and the 1D
states.Comment: 20 pages, latex, 3 uuencoded figures submitted separately (process
using psfig.sty
Nanoscale study of the as-grown hydrogenated amorphous silicon surface
A scanning tunneling microscope has been used to study the topography of the as-grown surface of device-quality, intrinsic, hydrogenated amorphous silicon deposited by rf discharge from silane. The substrates were atomically flat, oxide-free, single-crystal silicon or gallium arsenide. No evidence for island formation or nanoscale irregularities was seen in studies of 100-Å-thick films on either silicon or gallium arsenide. The topography of 1000- and 4000-Å-thick films has much variation; many regions can be characterized as rolling hills, but atomically flat areas have also been observed nearby. Generally, it appears that surface diffusion plays a role in smoothing the film topography. In most regions, the observed slopes were 10% or less from horizontal, but some steep-sided valleys, indicating incipient voids, were observed. The effect of the finite size of the scanning tunneling microscope probe tip is considered; this has an effect on the observed images in some cases
The Emergence of Sparse Spanners and Greedy Well-Separated Pair Decomposition
A spanner graph on a set of points in contains a shortest path between
any pair of points with length at most a constant factor of their Euclidean
distance. In this paper we investigate new models and aim to interpret why good
spanners 'emerge' in reality, when they are clearly built in pieces by agents
with their own interests and the construction is not coordinated. Our main
result is to show that if edges are built in an arbitrary order but an edge is
built if and only if its endpoints are not 'close' to the endpoints of an
existing edge, the graph is a (1 + \eps)-spanner with a linear number of
edges, constant average degree, and the total edge length as a small
logarithmic factor of the cost of the minimum spanning tree. As a side product,
we show a simple greedy algorithm for constructing optimal size well-separated
pair decompositions that may be of interest on its own
Hadroproduction and Polarization of Charmonium
In the limit of heavy quark mass, the production cross section and
polarization of quarkonia can be calculated in perturbative QCD. We study the
-averaged production of charmonium states in collisions at
fixed target energies. The data on the relative production rates of \jp and
is found to disagree with leading twist QCD. The polarization of the
\jp indicates that the discrepancy is not due to poorly known parton
distributions nor to the size of higher order effects (-factors). Rather,
the disagreement suggests important higher twist corrections, as has been
surmised earlier from the nuclear target -dependence of the production cross
section.Comment: 19 page
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy enhancer and polycomb repressive complex (PRC2)-marked regulatory regions. Genetic suppression of STAG2 leads to a compensatory increase in cohesin-STAG1 complexes, but not in enhancer-rich regions, and results in reprogramming of cis-chromatin interactions. Strikingly, in STAG2 knockout cells the oncogenic genetic program driven by the fusion transcription factor EWS/FLI1 was highly perturbed, in part due to altered enhancer-promoter contacts. Moreover, loss of STAG2 also disrupted PRC2-mediated regulation of gene expression. Combined, these transcriptional changes converged to modulate EWS/FLI1, migratory, and neurodevelopmental programs. Finally, consistent with clinical observations, functional studies revealed that loss of STAG2 enhances the metastatic potential of Ewing sarcoma xenografts. Our findings demonstrate that STAG2 mutations can alter chromatin architecture and transcriptional programs to promote an aggressive cancer phenotype
The Decreasing Significance of Stigma in the Lives of Bisexual Men: Keynote Address, Bisexual Research Convention, London
This article is constructed around a keynote address given at the Bisexual Research Convention, held in London 2010. The keynote was delivered by sociologist Eric Anderson, on behalf of himself and the other authors of this article. The keynote reflected upon a body of ongoing research, funded by the American Institute of Bisexuality and collected by this team of researchers, into the changing relationship between men and homophobia. It first contextualizes 20th-century attitudes toward homo/bisexuality before showing a declining significance of biphobia and homophobia in men's lives today. In accordance with the keynote, this article draws from preliminary findings of multiple ongoing studies of bisexual men in the United States and the United Kingdom
\psi(2S) Decays into \J plus Two Photons
Using \gamma \gamma J/\psi, J/\psi \ra e^+ e^- and events
from a sample of \psip decays collected with the BESII
detector, the branching fractions for \psip\ra \pi^0\J, \eta\J, and
\psi(2S)\ar\gamma\chi_{c1},\gamma\chi_{c2}\ar\gamma\gamma\jpsi are measured
to be B(\psip\ra \pi^0\J) = (1.43\pm0.14\pm0.13)\times 10^{-3}, B(\psip\ra
\eta\J) = (2.98\pm0.09\pm0.23)%,
B(\psi(2S)\ar\gamma\chi_{c1}\ar\gamma\gamma\jpsi) = (2.81\pm0.05\pm 0.23)%,
and B(\psi(2S)\ar\gamma\chi_{c2}\ar\gamma\gamma\jpsi) = (1.62\pm0.04\pm
0.12)%.Comment: 7 pages, 6 figures. submitted to Phys. Rev.
Prime movers : mechanochemistry of mitotic kinesins
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams. Different kinesins walk directionally along dynamic microtubules, anchor, crosslink, align and sort microtubules into polarized bundles, and influence microtubule dynamics by interacting with microtubule tips. The mechanochemical mechanisms of these kinesins are specialized to enable each type to make a specific contribution to spindle self-organization and chromosome segregation
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