KAJIAN KERASIONALAN PENGGUNAAN OBAT PADA KASUS DEMAM TIFOID DI INSTALASI RAWAT INAP ANUTAPURA PALU

KAJIAN KERASIONALAN PENGGUNAAN OBAT PADA KASUS DEMAM TIFOID DI INSTALASI RAWAT INAP ANUTAPURA PALU  Joni Tandi1)1)Program studi S1 Farmasi, STIFA Pelita Mas [email protected]  ABSTRACT It has been done a research about The Rasionality Study of Using Medicing to Typhoid fever case in Care Stay Installation Anutapura Palu. The aim of the rereseanch is to learn the comparasion applicability in using medicinal medical record medicine to prestige than literature by observting the data about the use medicine to typhoid fever patien witch who cared in. Although a research sampel was taking several patient have typhoid fever in drawn based og quota sampling method. The parameter used was the percentage applicability medicine based on dosage, indication, interaction medicine and side effect medicine. The result of study indicatesthat the percentage about using medicine based on the appropriate precise dosage in 82,22%, percentage of dug use based on the exact indication of the suit is 100%, while percentage of drug interactions do not occur 100% of drug interactions and side effects percentage is also 100% no comlaints of unintendad side effects of drugs.  Keywords :Typhoid Fever Medicine ABSTRAK  Telah dilakukan penelitian tentang Kajian Rasionalitas Penggunaan Obat Pada Kasus Demam Tifoid Di Instalasi Rawat Inap Anutaputra Palu dengan tujuan untuk mengetahui perbandiangan kesesuaian penggunaan obat distatus dengan bagian rekam medik. Populasi penelitian adalah pasien Demam Tifoid yang dirawat, sedangkan sampel penelitian adalah beberapa pasien Demam Tifoid yang di ambil berdasarkan metode teknik quota sampling. Parameter  yang digunakan  adalah presentase kesesuaian obat berdasarkan dosis, indikasi, interaksi obat dan efek samping obat. Hasil studi menunjukkan bahwa persentase penggunaan obat berdasarkan tepat dosis yang sesuai adalah 82,22%, persentase penggunaan obat berdasarkan tepat indikasi  yang sesuai adalah 100%, persentase interaksi obat 100% tidak terjadi interaksi obat dan persentase efek samping juga 100% tidak ada keluhan efek samping yang tidak diharapkan dari obat. Kata kunci : Obat Demam Tifoid Â

TINJAUAN POLA PENGOBATAN GASTRITIS PADA PASIEN RAWAT INAP RSUD LUWUK

TINJAUAN POLA PENGOBATAN GASTRITIS PADA PASIEN RAWAT INAP RSUD LUWUK  Joni Tandi11)Program Studi S1 Farmasi, STIFA Pelita Mas PaluEmail:[email protected] ABSTRACT Iit has been done a research about the Treatment of Gastritis review to Patients. Hospitalized In Luwuk General Hospital. Of the research  is the aim which were to find out the pattern of the Treatment of Gastritis Patients Hospitalized at General Hospital Area Of Luwuk by looking at data about drug use on the patient record on the Medic gastritis. The origin of the research was gastritis patients hospitalized at general hospital area of Luwuk. While the sample of research were some of the patients which were taken according to which were the methods of gastritis sampling technique quota sampling. The parameters used were based on the percentage of drug dose, fulfil indication, accuracy of the drug and the side effects of the drug. Result of the study show that the percentage of drug use based on indications that match 100%, the percentage of drug use based on the exact dose appropriate 92,77%, the percentage of drug use based on the precision of the appropriate remedy, the percentage of use of 97,59% based on drug side effects according to 97,59%.  Keywords: Gastritis Remedy ABSTRAK Telah dilakukan penelitian tentang Tinjauan Pola Pengobatan Gastritis Pada Pasien Rawat Inap Rumah Sakit Umum Daerah Luwuk, dengan tujuan untuk mengetahui pola pengobatan gastritis pada pasien rawat inap di Rumah Sakit Umum Daerah Luwuk dengan melihat data tentng obat yang digunakan pada pasien gastritis pada bagian rekam medik. Populasi penenlitian adalah pasien penderita gastritis rawat inap pada. Sedangkan yang menjadi sampel penelitian adalah beberapa pasien gastritis yang diambil berdasarkan metode sampling dengan tekhnik quota sampling . parameter yang digunakan adalah persentase kedesuaian obat berdasarkan dosis, indikasi, ketepatan obat dan efek samping obat. Hasil studi menunjukkan bahwa persentase penggunaan obat berdasarkan tepat indikasi yang sesuai  100%, persentase penggunaan obat berdasarkan tepat dosis yang sesuai 92,77%, persentase penggunaan obat berdasarkan ketepatan obat yang sesuai 97,59%. Persentasepenggunaan obat berdasarkan efek samping obat yang sesuai 97,59%. Kata kunci: Obat Gastritis     

PENGARUH EKSTRAK ETANOL DAUN JAMBU AIR (Syzygium aqueum (Burm f.)Alston) TERHADAP GLUKOSA DARAH, UREUM DAN KREATININ TIKUS PUTIH (Rattus norvegicus)

Diabetes mellitus with complications of Diabetic Nephropathy become one of the most common cause of end-stage renal failure in the world. Impaired kidney function is measured by Glomerular Filtration Rate (GFR). Where the decline in GFR was followed by increased levels of blood glucose, urea and creatinine. This study aimed to determine whether there is the content of secondary metabolites in leaves of Sizygium aqueum leaf extract, at a dose of extract what impact the blood glucose, urea and creatinine levels of male rats and whether the water extract of guava leaves have an influence on the blood glucose, urea and creatinine white male rats. This study uses a randomized block design with six treatment groups consisting of five test animals. Group I was normal control (CMC Na suspension 0.5%). Group II negative control (streptozotocin 40 mg/kg). positive control group III (suspension glibenclamide). Group IV given guava leaf extract 100 mg/kg BW. V group awarded guava leaf extract 200 mg/kg BW. Group VI given guava leaf extract 300 mg/kg BW. Treatment was given for 28 days and measured levels of blood glucose urea and creatinine on days 0, 7, 14, 21 and 28. The results showed nefroprotektif effect on all groups and most effective extract are a group of guava leaf extract 100 mg/kg BW). Keywords: Diabetic nephropathy, urea, creatinine, Syzygium aqueu

KAJIAN PERESEPAN OBAT ANTIBIOTIK PENYAKIT ISPA PADA ANAK DI RSU ANUTAPURA PALU TAHUN 2017

KAJIAN PERESEPAN OBAT ANTIBIOTIK PENYAKIT ISPA PADA ANAK DI RSU ANUTAPURA PALU TAHUN 2017Joni Tandi1, Mufidah Penno1), Valen Ruterlin2), Ardiyanto Panggeso2)1)Program Studi S1 Farmasi, STIFA Pelita Mas Palu2)RSUAnutapura Palu, Sulawesi TengahEmail:[email protected] study aims to examine and to get a picture of the pattern of antibiotic used by patients with ARI in children who underwent inpatient at RSU Anutapura Palu and know the rationale of the use of antibiotic drug ARI disease in children who underwent inpatient at RS Anutapura Palu. This research was descriptive with prospective data collecting from October to December year 2016 to patient of urinary tract infection at inpatient installation of AnutapuraPalu Hospital which fulfill inclusion criteria. Sampling technique with purposive sampling, and was administered on 38 patients. The results showed the most widely used antibiotics were ceftriaxone (73.69%), cefotaxime (21.05%) and cefixime (5.26%). with accuracy of antibiotics based on 100% accurate parameter, 100% precise drug, proper dose covering precise dosage 71,05%, precise frequency 55,26% and precise duration of giving 15,79% and 100% patient right.Keywords: Study, Antibiotics, Acute Respiratory InfectionsABSTRAKPenelitian ini bertujuan untuk Mengetahui dan memperoleh gambaran mengenai pola penggunaan antibiotik pasien ISPA pada anak yang menjalani rawat inap di RSU Anutapura Palu dan Mengetahui kerasionalan penggunaan obat antibiotik penyakit ISPA pada anak yang menjalani rawat inap di RS Anutapura Palu. Penelitian ini berupa penelitian deskriptif dengan pengumpulan data dilakukan secara prospektif dari bulan Juni sampai Agustus tahun 2017 terhadap pasien infeksi saluran pernapasan akut di instalasi rawat inap Rumah Sakit Umum Anutapura Palu yang memenuhi criteria inklusi. Teknik pengambilan sampel dengan Purposive Sampling, dan diperoleh sampel sebanyak 38 pasien. Hasil penelitian menunjukkan Antibiotik yang paling banyak digunakan adalah ceftriaxone 73,69%, cefotaxime 21,05% dan cefixime 5,26 %. ketepatan pemberian antibiotik berdasarkan parameter tepat indikasi 100 %, tepat obat 100 %, tepat dosis yang meliputi tepat besaran dosis 71,05%, tepat frekuensi 55,26% dan tepat durasi pemberian 15,79% serta tepat pasien 100%. Kata Kunci : Kajian, Antibiotik, Infeksi Saluran Pernapasan Aku

POLA PENGGUNAAN OBAT PADA PASIEN PENYAKIT HATI YANG MENJALANI RAWAT INAP DI RUMAH SAKIT UMUM DAERAH UNDATA PALU

Telah dilakukan penelitian tentang pola penggunaan obat pada pasien penyakit hati yang menjalani rawat inap di Rumah Sakit Umum Daerah Undata Palu, dengan tujuan untuk mengetahui pola penggunaan obat pada pasien penyakit hati yang menjalani rawat inap di Rumah Sakit Umum Daerah Undata Palu dengan melihat data tentang obat yang digunakan pada pasien penyakit hati pada bagian rekam medik. Populasi penelitian adalah pasien penderita penyakit hati rawat inap pada, sedangkan yang menjadi sampel penelitian adalah beberapa pasien penyakit hati yang diambil berdasarkan tekhnik probabiliti sampling. Parameter yang digunakan adalah persentase berdasarkan jenis pelayanan kesehatan, usia, penggunaan obat yang paling banyak digunakan dan penggunaan cairan cairan infus. Hasil studi menunjukan bahwa persentase berdasarkan jenis pelayanan kesehatan terbanyak yaitu jamkesmas (19-64 tahun) 80%, persentase berdasarkan penggunaan obat yang banyak digunakan yaitu curcuma 20%, persentase berdasarkan penggunaan cairan infus terbanyak yaitu ringer laktat 76,5%, persentae berdasarkan jenis penyakit hati terbanyak yaitu hepatitis 90%

Test of the Potential of Ethanol Extracts, Simplician Medium and Forest Umbi Juice (Eleutherine bulbosa (Factory) Urb.) against Blood Glucose Levels of Rats, and Histopatology Ratkreas Rat (Rattus norvegicus) Hypercolesterolemia Model Diabetic

This study aims to examine the presence or absence of secondary metabolite compounds in ethanol extract, simplicia steeping and forest onion tuber juice, in male glucose parameters and pancreatic histopathology. Using test animals as many as 30 male white rats divided into 6 groups and each group consisted of 5 rats with group I details as normal controls, group II as negative controls given 0.5% Na-CMC suspension, group III as positive control who were given Metformin 45 mg / kg BB and IV, V, VI as the test group were given ethanol extract, simplicia extract and forest onion tuber juice with each dose of 20 g / kg BW. The results showed that there were secondary metabolites in the ethanol extract of forest onion tubers, namely flavonoids, saponins, alkaloids, steroids and tannins, giving ethanol extract of forest onion bulbs had the effect of reducing blood glucose levels in white mice with a dose of 20g / kgBW with an average of 132 and ethanol extract of forest onion bulbs at a dose of 20g / kg BB with an average of 0.5 can regenerate pancreatic tissue

Efek Nefroprotektif Kombinasi Ekstrak Daun Gedi Merah dan Daun Kumis Kucing pada Tikus Induksi Etilen Glikol

Nephroprotective compound is a compound that has the ability to protect the kidneys from kidney disorders caused by free radicals. This research aimed to determine the nephroprotective effect of the combination of Abelmoschus manihot leaves and Orthosiphon stamineus leaves extract as well as to know the effective extract dose combinations as nephroprotective. This research applied Group Random Design with 6 treatment groups consists of 5 tested animals. Group I was normal control.  Group II was negative control. All extract groups was given 0,75% of ethylene glycol and 2% of ammonium chloride. Group III was given 100 mg/kg BW of Abelmoschus manihot leaves extract and 200 mg/kg BW of Orthosiphon stamineus leaves extract. Group IV was given 50 mg/kg BW of Abelmoschus manihot leaves extract and 100 mg/kg BW of Orthosiphon stamineus leaves extract. Group V was given 100 mg/kg BW of Abelmoschus manihot leaves extract. Group VI was given 200 mg/kg BW of Orthosiphon stamineus leaves extract. Treatment was given for 14 days and the levels of creatine and urea were measured on day 0, 8 and 15. The results show the nephroprotective effect in all the extract groups, but the most effective one was the group III

Phytochemical Analysis and Cytotoxic Activities of Hantap Leaves (<i>Sterculia coccinea</i> Jack) Extract

Hantap (Sterculia coccinea Jack) has been used traditionally for various health issues, including cancer treatment. The therapeutic effects of natural ingredients are often attributed to their chemical constituents. This study aimed to analyze the phytochemical contents and cytotoxic activities of S. coccinea leaves on HeLa and MCF-7 cancer cell lines. The quantitative phytochemical analysis was carried out following standard laboratory procedures. Phytochemical compounds were identified using LC-MS/MS QTOF. The MTT assay PrestoBlue™ Cell Viability Reagent test method was used to test cytotoxic activity in the cell culture. Extraction was carried out by the maceration method using 96% ethanol as solvent. The quantitative analysis revealed that tannins were the major phytochemical constituent in the highest percentage of 72.16%, followed by alkaloids, flavonoids, and steroids, with values of 30.80, 28.66, and 2.85%, respectively. Saponins were present in the lowest percentage of 1.15%. The ethanolic extract exhibited moderate cytotoxicity on HeLa and MCF-7 cells with IC50 values of 591.00 and 578.10 µg/mL, respectively. Identification using LC-MS/MS showed the suspected compounds 5,7-dihydroxy-3-(4'-hydroxybenzyl)chromone as homoisoflavanones and kaempferide-3-O-α-L-rhamnosyl-7-O-α-L-rhamnoside from flavonol triglycosides. These results may contribute to the study on the use of leaves extract of S. coccinea for developing a chemoprevention agent

Effectiveness Test of Mangrove Leaf (Rhizophora Apiculata) on Decreasing Blood Glucose Levels and Pancreas Histopatology Streptozotocin Induced Male White Rats

Hyperglycemia, a symptom of diabetes mellitus, can lead to oxidative stress, which is indicated by elevated malondialdehyde levels. Mangrove (Rhizophora apiculata) contains secondary metabolites of alkaloids, flavonoids, saponins and tanins, this can lessen how much oxidative stress there is in DM. This study intends to demonstrate the efficacy of mangrove extracts in lowering blood glucose levels and detecting pancreatic damage. The study used 30 male Wistar rats which were divided into 6 groups (group I: normal control, group II: negative and group III: positive control given glibenclamide 0.45 mg) and the test group (trial group). group IV: level 25 mg/kg BW, group V: level 50 mg/kg BW and VI: level 75 mg/kg BW) The DM model was made by streptozotocin induction. Pancreatic damage seen at 700 magnification saw pancreatic β cells as well as the islets of Langerhans' endocrine cells. The results of research on ethanol from mangrove leaves at levels of 75 mg/kg BW are substances that are effective at lowering blood sugar levels, which on average were 105 mg/dL with a hazard value of 1.2. When compared with glibenclamide mangrove extract is not equivalent to glibenclamide but has lowered glucose levels