Microsatellite data from parasites

This data consists genotypes obtained from Schistosoma mansoni parasites that were type at nine microsatellite markers. Each locus (e.g. L46951) is coded by 6 digits (e.g. 169175). Each allele is coded by 3 digits (e.g. 169)

Human host data

Village: location where human host lived. Host: population number that was assigned to the human host. HostIdentifier: code that is linked with that host. SamplingTime: time when parasites were sampled (e.g. Aug-09 or 09-Aug means that parasites were sampled from this host in August 2009. Age: age of the human host. EPG: eggs per gram of feces, i.e. a measure of infection intensity. CoInfectionWithShaematobium: 1 = when human host was coinfected with Schistosoma haematobium, 0 = when human host was NOT coinfected

R script written for some of the analyses

This is an R script that was written for some of the analysis, namely: 1) hierarchical f-statistics 2) tests for inbreeding with multilocus heterozygosity and 3) tests for family structure with relatedness estimate

IFN-γ secreting cells (ISC) with the sum of peptides (A), the single pool (B) per 10⁶ PBMCs to the HIV+ART<b>–</b> group and HIV+ART+ group at the baseline timeline versus post vaccination.

*<p>Mann Whitney test.</p

Epidemiological and clinical characteristics of HIV-1 eligible volunteers.

<p>Data are median (interquartile range) values when indicated.</p>*<p>ALAT: alanine transferase.</p

CD4+ T cell responses and HIV RNA load measurements after MVA85A vaccination.

<p>(A) CD4+ T cell count in 12 HIV+ART−, volunteers (group 1) and (B) in 12 HIV+ART+ volunteers (group 2). (C) HIV RNA load in 12 HIV+ART<b>–</b> volunteers (group 1) and (D) in 12 HIV+ART+ volunteers (group 2). Median values shown in red.</p

Immunogenicity of MVA85A – HIV+ART– group (A, B, C) compared to HIV+ART+ group (D, E, F).

<p>Measured by ex vivo ELISpot assay in the sum of pool of antigen 85A peptides <b>(A, D)</b>, the single pool of 66 peptides antigen 85A <b>(B, E)</b> and in the recombinant antigen 85A <b>(C, F)</b>. The figures also compare the responses after the first (arrow) and second vaccination (arrow).</p

Reasons for exclusion from recruitment into the trial.

*<p>Some subjects were excluded for more than one reason.</p

IFN-γ secreting cells (ISC) with the summed peptide pools (A, C), the single pool (B, D) per 10⁶ PBMCs for the HIV+ART<b>–</b> and HIV+ART+ groups after the first dose and second dose of MVA85A.

<p>Mann Whitney test was used.</p