A comparative analysis of the cycle fecundity rates associated with ovarian hyperstimulation along with IUI versus medical management in the treatment of mild to moderate oligozoospermia in males

Background: To compare the pregnancy rate in infertile couples with mild to moderate oligozoospermia receiving ovarian hyperstimulation and IUI, with that of medical management with CC.Methods: A total 120 couples with males having sperm concentration between 5 to 20 million/ml, normal serum gonadotropins and testosterone, and a presumptively fertile partner were enrolled in this prospective clinical study, during the study period of 19 months, 31st January 2019 till 1st September 2020. 120 couples were divided randomly into two groups A (n=60) and B (n=60). In group A, 60 couples were subdivided equally into 3 groups, each having 20 couples. Ovarian hyperstimulation protocols with IUI were used in different subgroups in group A.  A total of 216 IUI cycles done for 60 couples. While in group B, 60 males with oligozoospermia were prescribed CC treatment 25mg/day on alternate days for 3 months.Results: Out of 60 patients in group A, 24 achieved pregnancy with a cycle fecundity rate of 4% in CC+IUI, 9.87% in HMG+CC+IUI and 21.67% in HMG+IUI. 5 out of 60 patients in group B achieved pregnancy with cycle fecundity rate of 2.78%.Conclusions: These data suggest that acceptable pregnancy rates can be achieved with IUI combined with ovarian hyperstimulation in males with oligozoospermia. The role of CC treatment in males with oligozoospermia in improving the pregnancy outcome is extremely mearge. Thus, owing to the cost effectiveness and non-invasive modality, IUI is preferred prior to other more invasive and potentially costly reproductive technologies in the treatment of male factor subfertility

A study on cervical cytopathology in HIV positive pregnant women in Southern part of Assam, India

Background: The association between abnormal cervical cytology and HIV infection status in pregnant women was evaluated to correlate with CD4 cell count, viral load and ART compliance in HIV positive pregnant patients with the presence of ASC-US, LSIL and HSIL.Methods: Cervical samples were collected at the Antenatal Clinic of Silchar Medical College and Hospital. An Ayre’s spatula was used to collect samples from the ectocervix and a cytology brush to collect samples from the endocervix.Results: Of a total of 75 antenatal attendees, 43 were HIV positive and 32 were HIV negative. Abnormal cytology (N=26, 60.46%) was more common in HIV positive group compared to the HIV negative group (N=7, 21.87%) with a p value of 10,000/mm3) and poor treatment follow up with ART.Conclusions: HIV positive pregnant women are more likely to have cervical lesions as compared to the HIV negative. This higher frequency of abnormal findings in PAP cytology in HIV positive pregnant women with higher viral loads suggest association between preinvasive cervical lesions and human immune deficiency

A rare case of abnormal uterine bleeding in a perimenopausal woman with chronic uterine inversion caused by extrusion of benign fundal submucosal fibromyoma

Uterine inversion secondary to a pathological process of the myometrium is very rare. We report the case of a 48-year-old woman presenting with abnormal uterine bleeding (AUB) and mass like sensation in vaginal canal, in whom a study by MRI demonstrated a uterine inversion with submucosal pedunculated leiomyoma. She had undergone total abdominal hysterectomy (TAH) and ovaries were preserved bilaterally

Voltage stability assessment of a power system incorporating FACTS controllers using unique network equivalent

AbstractVoltage instability is considered as a main threat to stability, security, and reliability in the modern power systems. Prediction of voltage stability limit of multi-bus system through its two-bus equivalent model is a hot topic of the research in the field of power system operation and control. This paper presents a novel method to assess voltage stability status using a unique two-bus π-network equivalent derived with OPF solution of the actual system at different operating conditions. As the FACTS controllers are now an ineluctable part of power system, this paper considers an SVC and a TCSC in OPF formulation to assess voltage stable states of any interconnected power system in terms of its reduced two-bus integrated π-equivalent system. Simulation results for a practical power system establish that the proposed methodology is highly promising to assess voltage stability in a better way as compared to existing series equivalent model

Role of carbonate burial in Blue Carbon budgets

Unidad de excelencia María de Maeztu MdM-2015-0552Altres ajuts: "Obra Social la Caixa" fellowship (LCF/BQ/ES14/10320004)Calcium carbonates (CaCO3) often accumulate in mangrove and seagrass sediments. As CaCO3 production emits CO2, there is concern that this may partially offset the role of Blue Carbon ecosystems as CO2 sinks through the burial of organic carbon (Corg). A global collection of data on inorganic carbon burial rates (Cinorg, 12% of CaCO3 mass) revealed global rates of 0.8TgCinorg yr−1 and 15-62TgCinorg yr−1 in mangrove and seagrass ecosystems, respectively. In seagrass, CaCO3 burial may correspond to an offset of 30% of the net CO2 sequestration. However, a mass balance assessment highlights that the Cinorg burial is mainly supported by inputs from adjacent ecosystems rather than by local calcification, and that Blue Carbon ecosystems are sites of net CaCO3 dissolution. Hence, CaCO3 burial in Blue Carbon ecosystems contribute to seabed elevation and therefore buffers sea-level rise, without undermining their role as CO2 sinks

Pleiotropic brain function of whirlin identified by a novel mutation

Despite some evidence indicating diverse roles of whirlin in neurons, the functional corollary of whirlin gene function and behaviour has not been investigated or broadly characterised. A single nucleotide variant was identified from our recessive ENU-mutagenesis screen at a donor-splice site in whirlin, a protein critical for proper sensorineural hearing function. The mutation (head-bob, hb) led to partial intron-retention causing a frameshift and introducing a premature termination codon. Mutant mice had a head-bobbing phenotype and significant hyperactivity across several phenotyping tests. Lack of complementation of head-bob with whirler mutant mice confirmed the head-bob mutation as functionally distinct with compound mutants having a mild-moderate hearing defect. Utilising transgenics, we demonstrate rescue of the hyperactive phenotype and combined with the expression profiling data conclude whirlin plays an essential role in activity-related behaviours. These results highlight a pleiotropic role of whirlin within the brain and implicates alternative, central mediated pathways in its function

Restoring India's Terrestrial Ecosystems: Needs, Challenges, and Policy Recommendations

<p>This document is a product of the preparatory phase project of the National Mission on Biodiversity and Human Well-Being which was catalysed and supported by the Office of the Principal Scientific Advisor to the Government of India. It is the outcome of a series of stakeholder consultation meetings on ecological restoration of terrestrial landscapes and climate change in India. The insights from these meetings have been used to develop this document which highlights the challenges and best-practices in the restoration of terrestrial ecosystems, can serve as a guide for successful restoration of landscapes across different biomes of the Indian subcontinent, and help achieve India’s commitments to the Bonn Challenge and the goals set by India for biodiversity conservation, land restoration, climate mitigation and adaptation.</p&gt