22 research outputs found
Propuesta de mejora en el área de producción para reducir costos operativos en la empresa Inca Verde del Perú SAC
RESUMEN
El presente trabajo tuvo como objetivo general: Reducir los costos operativos de la empresa Inca Verde del Perú S.A.C., a través de la propuesta de mejora en el área de producción.
Realizando un diagnóstico de la situación actual con el uso del análisis causa-efecto o también llamado Diagrama de Ishikawa para identificar las principales causas del problema las cuales principalmente fueron: Deficiente planificación de la producción, falta de estudio de tiempos y movimientos, inexistencia de un plan de capacitación en los principales procesos de producción entre otros. Para los cuales se propusieron herramientas de mejora tales como: Plan de Requerimiento de Materiales, Estudio de Tiempos, Plan de capacitación, Aplicación de 5 S entre otros.
Los resultados que se lograron fueron una reducción de costos en S/148.837 soles anuales de un total inicial de S/. S/. 315.471,53
Finalmente se realizó la evaluación económica financiera para la propuesta de mejora en el área de producción, obteniendo un VAN de S/. 128,567, un TIR de 80% y un Beneficio Costo de 1.41 lo cual indica la viabilidad del proyecto.ABSTRACT
The present work had as general objective: Reduces the operative costs of the business Inca Verde del f Peru S.A.C., trought the proffer of improvement in the area of production.
Realizing a diagnosis of the current situation with the use of the analysis cause - effect or also called Ishikawa's Graph to identify the principal reasons of the problem, which principally were: Deficient planning of the production, lack of study of times and movements, non-existence of a plan of training in the principal processes of production and others. For which, proposed tools of improvement such as: Plan of Requirement of Materials, Study of Times, Plan of training, Application of 5 S between others
The results achieve wee
The results achieved were a reduction of costs from S/148.837 annual to S/. S/. 315.471,53. annual
Finally, the economic financial evaluation for the propuse of improvement in the area of production, obtaining a VNA of S/. 128,567, one TIR of 80 % and a Benefit Cost of 1.41 which indicates the viability of the project
Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration
Gluten promotes type 1 diabetes in nonobese diabetic (NOD) mice and likely also in humans. In NOD mice and in non-diabetes-prone mice, it induces inflammation in the pancreatic lymph nodes, suggesting that gluten can initiate inflammation locally. Further, gliadin fragments stimulate insulin secretion from beta cells directly. We hypothesized that gluten fragments may cross the intestinal barrier to be distributed to organs other than the gut. If present in pancreas, gliadin could interact directly with the immune system and the beta cells to initiate diabetes development. We orally and intravenously administered 33-mer and 19-mer gliadin peptide to NOD, BALB/c, and C57BL/6 mice and found that the peptides readily crossed the intestinal barrier in all strains. Several degradation products were found in the pancreas by mass spectroscopy. Notably, the exocrine pancreas incorporated large amounts of radioactive label shortly after administration of the peptides. The study demonstrates that, even in normal animals, large gliadin fragments can reach the pancreas. If applicable to humans, the increased gut permeability in prediabetes and type 1 diabetes patients could expose beta cells directly to gliadin fragments. Here they could initiate inflammation and induce beta cell stress and thus contribute to the development of type 1 diabetes
Corrigendum to "Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration"
Circulating Antinuclear Antibodies in Patients with Pelvic Masses Are Associated with Malignancy and Decreased Survival
BACKGROUND: Circulating autoantibodies occur more frequently in cancer patients than in patients without cancer. METHODS AND FINDINGS: We examined sera from patients referred for pelvic mass symptoms to a tertiary university clinic. A total of 127 were diagnosed with epithelial ovarian cancer while 386 had a benign condition. A screen for IgG anti-nuclear antibodies (ANA) by indirect immunofluorescence on HEp-2 cells confirmed a highly significant overrepresentation of ANA in the cancer group where 40% had detectable (i.e., a titer ≥160) ANA compared with less than 12% in the benign group. The overrepresentation of ANA in the cancer group persisted (p<0.0001) after matching the age-profile of the benign group with the ovarian cancer group. Only 19 out of 127 patients in the age-matched benign subgroup were positive for ANA corresponding to an 85% specificity at 40% sensitivity of ANA as the only marker for malignancy. No correlation of ANA positivity in either group with specific bands in immunoblots could be demonstrated even though immunoblot positivity was clearly increased in the malignant group (41% vs. 3%). The presence, strength, and type of ANA did not correlate with serum CA-125 values or with staging, and ANA outcome did not contribute with independent diagnostic information. However, survival was significantly shorter in ANA-positive compared with ANA-negative cancer patients and patients with CA-125 below the median CA-125 value in the cancer group had a significantly decreased survival when positive for ANA. ANA status made no difference in the group with CA-125 values above the median. Also, there was a significant correlation between speckled ANA-strength and histological tumor grade. CONCLUSIONS: Circulating antibodies are a promising source for new biomarkers in cancer. Characterization of epitope specificities and measurements of consecutive samples will be important for further elucidating the role of ANA in evaluating ovarian cancer patients
The influence of preanalytical conditions on the DJ-1 concentration in human cerebrospinal fluid
Filaggrin is a predominant member of the denaturation-resistant nickel-binding proteome of human epidermis
The DJ-1 concentration in cerebrospinal fluid does not differentiate among parkinsonian syndromes
Quantitative Proteome Profiling of Normal Human Circulating Microparticles
Circulating microparticles (MPs) are produced as part
of normal
physiology. Their numbers, origin, and composition change in pathology.
Despite this, the normal MP proteome has not yet been characterized
with standardized high-resolution methods. We here quantitatively
profile the normal MP proteome using nano-LC–MS/MS on an LTQ-Orbitrap
with optimized sample collection, preparation, and analysis of 12
different normal samples. Analytical and procedural variation were
estimated in triply processed samples analyzed in triplicate from
two different donors. Label-free quantitation was validated by the
correlation of cytoskeletal protein intensities with MP numbers obtained
by flow cytometry. Finally, the validity of using pooled samples was
evaluated using overlap protein identification numbers and multivariate
data analysis. Using conservative parameters, 536 different unique
proteins were quantitated. Of these, 334 (63%) were present in all
samples and represent an MP core proteome. Technical triplicates showed
<10% variation in intensity within a dynamic range of almost 5
decades. Differences due to variable MP numbers and losses during
preparative steps could be normalized using cytoskeletal MP protein
intensities. Our results establish a reproducible LC–MS/MS
procedure, provide a simple and robust MP preparation method, and
yield a baseline MP proteome for future studies of MPs in health and
disease