45,549 research outputs found
Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.
The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction. To understand the nature of the interaction between Ti and CD3, chimeric molecules which included the COOH-terminal segments of Ti alpha or beta linked to the extracellular segment of CD8, were transfected into a mutant T cell deficient in Ti beta chain expression and cell surface CD3. Both chimeric chains were required to express the chimeric Ti and to restore CD3 surface expression. CD8/Ti and CD3 cointernalized and coimmunoprecipitated. Stimulation of the chimeric receptor induced transmembrane signaling events and cell activation. These results demonstrate that the Ti alpha and beta COOH termini containing the transmembrane domains are sufficient for structural and functional coupling of Ti to CD3
Non-equilibrium spatial distribution of Rashba spin torque in ferromagnetic metal layer
We study the spatial distribution of spin torque induced by a strong Rashba
spin-orbit coupling (RSOC) in a ferromagnetic (FM) metal layer, using the
Keldysh non-equilibrium Green's function method. In the presence of the s-d
interaction between the non-equilibrium conduction electrons and the local
magnetic moments, the RSOC effect induces a torque on the moments, which we
term as the Rashba spin torque.
A correlation between the Rashba spin torque and the spatial spin current is
presented in this work, clearly mapping the spatial distribution of Rashba Spin
torque in a nano-sized ferromagnetic device. When local magnetism is turned on,
the out-of-plane (Sz) Spin Hall effect (SHE) is disrupted, but rather
unexpectedly an in-plane (Sy) SHE is detected. We also study the effect of
Rashba strength (\alpha_R) and splitting exchange (\Delta) on the
non-equilibrium Rashba spin torque averaged over the device. Rashba spin torque
allows an efficient transfer of spin momentum such that a typical switching
field of 20 mT can be attained with a low current density of less than 10^6
A/cm^2
Electron and trap dynamics in As-ion-implanted and annealed GaAs
The ultrafast dynamics of As-ion-implanted and annealed GaAs is investigated using transmission pump–probe measurements.Carrier recombination time was found to increase from 4 to 40 ps with increasing annealing temperature. At lower annealing temperatures, the transmitted optical signal is dominated by induced absorption and at higher annealing temperatures this effect is replaced by induced transparency.This work was supported in part by the EC INCOCOPERNICUS
project ‘‘DUO—devices for ultrafast optoelectronics’’
and the Lithuanian Science and Study Foundation
Learning circuits with few negations
Monotone Boolean functions, and the monotone Boolean circuits that compute
them, have been intensively studied in complexity theory. In this paper we
study the structure of Boolean functions in terms of the minimum number of
negations in any circuit computing them, a complexity measure that interpolates
between monotone functions and the class of all functions. We study this
generalization of monotonicity from the vantage point of learning theory,
giving near-matching upper and lower bounds on the uniform-distribution
learnability of circuits in terms of the number of negations they contain. Our
upper bounds are based on a new structural characterization of negation-limited
circuits that extends a classical result of A. A. Markov. Our lower bounds,
which employ Fourier-analytic tools from hardness amplification, give new
results even for circuits with no negations (i.e. monotone functions)
Clostridium difficile colitis in patients after kidney and pancreas-kidney transplantation
Limited data exist about Clostridium difficile colitis (CDC) in solid organ transplant patients. Between 1/1/99 and 12/31/02, 600 kidney and 102 pancreas–kidney allograft recipients were transplanted. Thirty-nine (5.5%) of these patients had CDC on the basis of clinical and laboratory findings. Of these 39 patients, 35 have information available for review. CDC developed at a median of 30 days after transplantation, and the patients undergoing pancreas–kidney transplantation had a slightly higher incidence of CDC than recipients of kidney alone (7.8% vs. 4.5%, P> 0.05). All but one patient presented with diarrhea. Twenty-four patients (64.9%) were diagnosed in the hospital, and CDC occurred during first hospitalization in 14 patients (40%). Treatment was with oral metronidazole (M) in 33 patients (94%)and M + oral vancomycin (M + V) in 2 patients. Eight patients had recurrent CDC, which occurred at a median of 30 days (range 15–314) after the first episode. Two patients (5.7%) developed fulminant CDC, presented with toxic megacolon, and underwent colectomy. One of them died; the other patient survived after colectomy. CDC should be considered as a diagnosis in transplant patients with history of diarrhea after antibiotic use, and should be treated aggressively before the infection becomes complicated
Evidence of Spatially Inhomogeous Pairing on the Insulating Side of a Disorder-Tuned Superconductor-Insulator Transition
Measurements of transport properties of amorphous insulating indium oxide
thin films have been interpreted as evidence of the presence of superconducting
islands on the insulating side of a disorder-tuned superconductor-insulator
transition. Although the films are not granular, the behavior is similar to
that observed in granular films. The results support theoretical models in
which the destruction of superconductivity by disorder produces spatially
inhomogenous pairing with a spectral gap.Comment: Revised title and content/argument. Totals: 4 pages, 3 figure
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