MENUMBUHKAN JIWA WIRAUSAHA BAGI JEMAAT PEREMPUAN DI GEREJA HKBP RESSORT WARAKAS JAKARTA

Pandemi Covid-19 membuat pemerintah Indonesia terpaksa membuat kebijakan Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) guna menekan penambahan kasus orang terpapar Covid-19 setiap harinya. Salah satu dampak dari pengetatan tersebut adalah banyaknya pekerja yang diberhentikan ataupun mengalami penurunan pendapatan akibat pengurangan jam kerja dan dirumahkan sementara. Hal ini tentu secara signifikan memengaruhi kebiasaan orang mengelola dan menggunakan uang dalam keluarga. Dalam kondisi seperti ini, kaum wanita dituntut untuk berperan lebih dalam menjaga ekonomi keluarga. Salah satunya adalah dengan mengidentifikasi peluang usaha yang ada dan memanfaatkannya. Itu sebabnya dalam rangka merayakan Parheheon Ina sekaligus memperingati hari Kartini, Gereja HKBP Ressort Warakas bekerjasama dengan Fakultas Ekonomi dan Bisnis Universitas Pelita Harapan mengadakan seminar dengan tema kewirausahaan untuk membangun serta menumbuhkan jiwa wirausaha jemaat wanita di Gereja tersebut sehingga dapat menambah pendapatan dan mendukung ketahanan finansial keluarga di tengah pandemi. Seminar telah dilakukan pada tanggal 23 April 2022 dan mendapatkan respons yang baik dari para peserta yang mendapatkan wawasan baru dan terinspirasi untuk memulai serta mengembangkan sebuah usaha

Advancing Technology for NASA Science with Small Spacecraft

NASA’s Science Mission Directorate (SMD) is strategically promoting the use of small spacecraft to advance its science portfolio. Related to this effort are an increasing number of targeted investments in instrument- and platform-based technologies, which are critical for achieving successful science missions with small spacecraft. Beginning in 2012, SMD’s technology programs began to accommodate the use of CubeSats for validation of new science instruments. Since that time the Directorate has expanded the use of CubeSats and small satellites not only for validating instruments for future, conventional-class missions but also to enable a new class of focused science missions that fill an important role in democratizing scientific discovery. To enable such missions, the Directorate has recently modified the portfolios of the Agency’s technology programs to accommodate this need. This paper outlines some of the processes that are used to craft the technology solicitations and discusses some of the recent selections that have been made. It is intended to help future proposers of small satellite missions to better understand the opportunities available through NASA technology solicitations

Evaluation of meteorological drought and flood scenarios over Kenya, East Africa

This work examines drought and flood events over Kenya from 1981 to 2016 using the Standardized Precipitation–Evapotranspiration Index (SPEI). The spatiotemporal analysis of dry and wet events was conducted for 3 and 12 months. Extreme drought incidences were observed in the years 1987, 2000, 2006, and 2009 for SPEI-3, whilst the SPEI-12 demonstrated the manifestation of drought during the years 2000 and 2006. The SPEI showed that the wettest periods, 1997 and 1998, coincided with the El Nino event for both time steps. SPEI-3 showed a reduction in moderate drought events, while severe and extreme cases were on the increase tendencies towards the end of the twentieth century. Conversely, SPEI-12 depicted an overall increase in severe drought occurrence over the study location with ab observed intensity of −1.54 and a cumulative frequency of 64 months during the study period. Wet events showed an upward trend in the western and central highlands, while the rest of the regions showed an increase in dry events during the study period. Moreover, moderate dry/wet events predominated, whilst extreme events occurred least frequently across all grid cells. It is apparent that the study area experienced mild extreme dry events in both categories, although moderately severe dry events dominated most parts of the study area. A high intensity and frequency of drought was noted in SPEI-3, while the least occurrences of extreme events were recorded in SPEI-12. Though drought event prevailed across the study area, there was evidence of extreme flood conditions over the recent decades. These findings form a good basis for next step of research that will look at the projection of droughts over the study area based on regional climate models

Quantile mapping bias correction on Rossby Centre Regional Climate Models for precipitation analysis over Kenya, East Africa

This study uses the quantile mapping bias correction (QMBC) method to correct the bias in five regional climate models (RCMs) from the latest output of the Rossby Center Climate Regional Model (RCA4) over Kenya. The outputs were validated using various scalar metrics such as root-mean-square difference (RMSD), mean absolute error (MAE), and mean bias. The study found that the QMBC algorithm demonstrates varying performance among the models in the study domain. The results show that most of the models exhibit reasonable improvement after corrections at seasonal and annual timescales. Specifically, the European Community Earth-System (EC-EARTH) and Commonwealth Scientific and Industrial Research Organization (CSIRO) models depict remarkable improvement as compared to other models. On the contrary, the Institute Pierre Simon Laplace Model CM5A-MR (IPSL-CM5A-MR) model shows little improvement across the rainfall seasons (i.e., March–May (MAM) and October–December (OND)). The projections forced with bias-corrected historical simulations tallied observed values demonstrate satisfactory simulations as compared to the uncorrected RCMs output models. This study has demonstrated that using QMBC on outputs from RCA4 is an important intermediate step to improve climate data before performing any regional impact analysis. The corrected models may be used in projections of drought and flood extreme events over the study area

Impact of DNA-binding position variants on yeast gene expression

Transcription factors (TFs) regulate gene expression by binding to specific binding sites (TFBSs) in gene promoters. TFBS motifs may contain one or more variable positions. Although the prevailing assumption is that nucleotide variants at such positions are functionally equivalent, there is increasing evidence that such variants play a role in regulation of gene expression. In this article, we propose a method for studying the relationship between the expression of target genes and nucleotide variants in TFBS motifs at a genome-wide scale in Saccharomyces cerevisiae, especially the combinatorial effects of variants at two positions. Our analysis shows that nucleotide variations in more than one-third of variable positions and in 20% of dependent position pairs are highly correlated to gene expression. We define such positions as ‘functional’. However, some positions are only functional as dependent pairs, but not individually. In addition, a significant proportion of the functional positions have been well conserved across all yeast-related species studied. We also find that some positions require the presence of co-occurring TFs, while others maintain their functionality in the absence of a co-occurring TF. Our analysis supports the importance of nucleotide variants at variable positions of TFBSs in gene regulation

Implementasi Pengamanan Citra Digital Berbasis Metode Kriptografi Vernam Cipher

Penggunaan media online dalam melakukan aktivitas telah semakin marak terjadi pada dinamika masyarakat modern. Salah satu obyek sasaran dalam aktivitas online adalah citra digital. Citra digital ini dapat diperuntukan untuk kalangan terbatas saja sehingga mudah menjadi sasaran oleh peretas, terutama jika data citra digital tersebut bersifat penting. Disinilah kriptografi mengambil peran penting dalam mengamankan citra digital. Dengan menggunakan teknik Vernam Cipher, pesan citra digital dapat diacak dengan kunci yang berbeda untuk setiap karakter, sehingga pesan citra digital hanya dapat dibaca oleh penerima saja. Hasil enkripsi akan menghasilkan citra baru dengan adanya perubahan pada intensitas warna piksel. Dari 12 gambar dengan ukuran kurang dari 100 KB, tingkat keberhasilannya adalah 100%. Algoritma ini sangat cepat, dengan kecepatan enkripsi rata-rata 0,007785 dan dekripsi 0,006903 untuk gambar berformat JPEG dan memiliki ukuran piksel 384x384 Berdasarkan penelitian tersebut maka dapat disimpulkan bahwa Algoritma Vernam Cipher adalah algoritma yang baik dan cepat

Primary tubercular caecal perforation: a rare clinical entity

<p>Abstract</p> <p>Background</p> <p>Intestinal tuberculosis is a common problem in endemic areas, causing considerable morbidity and mortality. An isolated primary caecal perforation of tubercular origin is exceptionally uncommon.</p> <p>Case presentation</p> <p>We report the case of a 39 year old male who presented with features of perforation peritonitis, which on laparotomy revealed a caecal perforation with a dusky appendix. A standard right hemicolectomy with ileostomy and peritoneal toileting was done. Histopathology revealed multiple transmural caseating granulomas with Langerhans-type giant cells and acid-fast bacilli, consistent with tuberculosis, present only in the caecum.</p> <p>Conclusions</p> <p>We report this extremely rare presentation of primary caecal tuberculosis to sensitize the medical fraternity to its rare occurrence, which will be of paramount importance owing to the increasing incidence of tuberculosis all over the world, especially among the developing countries.</p

Fermentation and purification strategies for the production of betulinic acid and its lupane-type precursors in Saccharomyces cerevisiae

Microbial production of plant derived, biologically active compounds has the potential to provide economic and ecologic alternatives to existing low productive, plant-based processes. Current production of the pharmacologically active cyclic triterpenoid betulinic acid is realized by extraction from the bark of plane tree or birch. Here, we reengineered the reported betulinic acid pathway into Saccharomyces cerevisiae and used this novel strain to develop efficient fermentation and product purification methods. Fed-batch cultivations with ethanol excess, using either an ethanol-pulse feed or controlling a constant ethanol concentration in the fermentation medium, significantly enhanced production of betulinic acid and its triterpenoid precursors. The beneficial effect of excess ethanol was further exploited in nitrogen-limited resting cell fermentations, yielding betulinic acid concentrations of 182mg/L, and total triterpenoid concentrations of 854mg/L, the highest concentrations reported so far. Purification of lupane-type triterpenoids with high selectivity and yield was achieved by solid-liquid extraction without prior cell disruption using polar aprotic solvents such as acetone or ethyl acetate and subsequent precipitation with strong acids. This study highlights the potential of microbial production of plant derived triterpenoids in S. cerevisiae by combining metabolic and process engineering

Further investigation of confirmed urinary tract infection (UTI) in children under five years: a systematic review.

Background: Further investigation of confirmed UTI in children aims to prevent renal scarring and future complications. Methods: We conducted a systematic review to determine the most effective approach to the further investigation of confirmed urinary tract infection (UTI) in children under five years of age. Results: 73 studies were included. Many studies had methodological limitations or were poorly reported. Effectiveness of further investigations: One study found that routine imaging did not lead to a reduction in recurrent UTIs or renal scarring. Diagnostic accuracy: The studies do not support the use of less invasive tests such as ultrasound as an alternative to renal scintigraphy, either to rule out infection of the upper urinary tract (LR- = 0.57, 95%CI: 0.47, 0.68) and thus to exclude patients from further investigation or to detect renal scarring (LR+ = 3.5, 95% CI: 2.5, 4.8). None of the tests investigated can accurately predict the development of renal scarring. The available evidence supports the consideration of contrast-enhanced ultrasound techniques for detecting vesico-ureteric reflux (VUR), as an alternative to micturating cystourethrography (MCUG) (LR+ = 14.1, 95% CI: 9.5, 20.8; LR- = 0.20, 95%CI: 0.13, 0.29); these techniques have the advantage of not requiring exposure to ionising radiation. Conclusion: There is no evidence to support the clinical effectiveness of routine investigation of children with confirmed UTI. Primary research on the effectiveness, in terms of improved patient outcome, of testing at all stages in the investigation of confirmed urinary tract infection is urgently required