959 research outputs found
Expression of killer cell immunoglobulin-like receptors (KIR) in sex-associated malignancies
Introduction: Sex shapes immune response with possible consequence on tumor immune escape. Acute lymphoblastic leukemia (ALL) predominates in males while ovarian cancer (OC) occurs in females. NK cells essential for
tumor killing may have male preponderance. Association of sex, NK cell activity and malignancies is unclear. We
hypothesize that sex differentially affects KIR expressions in sex-biased cancers. Method: Expression of inhibitory
(KIR2DL1-5 and KIR3DL1-3) and activating (KIR2DS1-2 and 4-5 and KIR3DS1) genes in B-, T-cell ALL, OC and normal controls were determined by reverse-transcription polymerase-chain-reaction. Result: All normal males (but not
females) expressed the framework genes and generally maintained haplotype A, except KIR3DL1. Normal females
expressed more activating KIRs. Frequencies of KIR2DL1, 2DL4 and 2DS2 were significantly reduced among ovarian
cancer patients. Sex difference in frequencies of KIR expression was not detected in ALL as majority were undetectable except framework gene KIR3DL2, was more frequent among T-ALL. Conclusion: Cancers may be associated
with reduced KIR expression and influence of sex requires investigation
X-linked microtubule-associated protein, Mid1, regulates axon development
Opitz syndrome (OS) is a genetic neurological disorder. The gene responsible for the X-linked form of OS, Midline-1 (MID1), encodes an E3 ubiquitin ligase that regulates the degradation of the catalytic subunit of protein phosphatase 2A (PP2Ac). However, how Mid1 functions during neural development is largely unknown. In this study, we provide data from in vitro and in vivo experiments suggesting that silencing Mid1 in developing neurons promotes axon growth and branch formation, resulting in a disruption of callosal axon projections in the contralateral cortex. In addition, a similar phenotype of axonal development was observed in the Mid1 knockout mouse. This defect was largely due to the accumulation of PP2Ac in Mid1-depleted cells as further down-regulation of PP2Ac rescued the axonal phenotype. Together, these data demonstrate that Mid1-dependent PP2Ac turnover is important for normal axonal development and that dysregulation of this process may contribute to the underlying cause of OS
Search for the decay
We search for radiative decays into a weakly interacting neutral
particle, namely an invisible particle, using the produced through the
process in a data sample of
decays collected by the BESIII detector
at BEPCII. No significant signal is observed. Using a modified frequentist
method, upper limits on the branching fractions are set under different
assumptions of invisible particle masses up to 1.2 . The upper limit corresponding to an invisible particle with zero mass
is 7.0 at the 90\% confidence level
The 2nd Workshop on Maritime Computer Vision (MaCVi) 2024
The 2nd Workshop on Maritime Computer Vision (MaCVi) 2024 addresses maritime
computer vision for Unmanned Aerial Vehicles (UAV) and Unmanned Surface
Vehicles (USV). Three challenges categories are considered: (i) UAV-based
Maritime Object Tracking with Re-identification, (ii) USV-based Maritime
Obstacle Segmentation and Detection, (iii) USV-based Maritime Boat Tracking.
The USV-based Maritime Obstacle Segmentation and Detection features three
sub-challenges, including a new embedded challenge addressing efficicent
inference on real-world embedded devices. This report offers a comprehensive
overview of the findings from the challenges. We provide both statistical and
qualitative analyses, evaluating trends from over 195 submissions. All
datasets, evaluation code, and the leaderboard are available to the public at
https://macvi.org/workshop/macvi24.Comment: Part of 2nd Workshop on Maritime Computer Vision (MaCVi) 2024 IEEE
Xplore submission as part of WACV 202
Observation of in
Using a sample of events recorded with
the BESIII detector at the symmetric electron positron collider BEPCII, we
report the observation of the decay of the charmonium state
into a pair of mesons in the process
. The branching fraction is measured for the first
time to be , where the first uncertainty is
statistical, the second systematic and the third is from the uncertainty of
. The mass and width of the are
determined as MeV/ and
MeV.Comment: 13 pages, 6 figure
Precise Measurements of Branching Fractions for Meson Decays to Two Pseudoscalar Mesons
We measure the branching fractions for seven two-body decays to
pseudo-scalar mesons, by analyzing data collected at
GeV with the BESIII detector at the BEPCII collider. The branching fractions
are determined to be ,
,
,
,
,
,
,
where the first uncertainties are statistical, the second are systematic, and
the third are from external input branching fraction of the normalization mode
. Precision of our measurements is significantly improved
compared with that of the current world average values
Observation of and confirmation of its large branching fraction
The baryonic decay is observed, and the
corresponding branching fraction is measured to be
, where the first uncertainty is statistical
and second systematic. The data sample used in this analysis was collected with
the BESIII detector operating at the BEPCII double-ring collider with
a center-of-mass energy of 4.178~GeV and an integrated luminosity of
3.19~fb. The result confirms the previous measurement by the CLEO
Collaboration and is of greatly improved precision, which may deepen our
understanding of the dynamical enhancement of the W-annihilation topology in
the charmed meson decays
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