CAutoCSD-evolutionary search and optimisation enabled computer automated control system design

This paper attempts to set a unified scene for various linear time-invariant (LTI) control system design schemes, by transforming the existing concept of 'Computer-Aided Control System Design' (CACSD) to the novel 'Computer-Automated Control System Design' (CAutoCSD). The first step towards this goal is to accommodate, under practical constraints, various design objectives that are desirable in both time and frequency-domains. Such performance-prioritised unification is aimed to relieve practising engineers from having to select a particular control scheme and from sacrificing certain performance goals resulting from pre-committing to the adopted scheme. With the recent progress in evolutionary computing based extra-numeric, multi-criterion search and optimisation techniques, such unification of LTI control schemes becomes feasible, analytically and practically, and the resultant designs can be creative. The techniques developed are applied to, and illustrated by, three design problems. The unified approach automatically provides an integrator for zero-steady state error in velocity control of a DC motor, meets multiple objectives in designing an LTI controller for a non-minimum phase plant and offers a high-performing LTI controller network for a nonlinear chemical process

Improvement of dielectric loss of doped Ba0.5Sr0.5TiO3 thin films for tunable microwave devices

Al2O3-Ba0.5Sr0.5TiO3 (Al2O3-BST) thin films, with different Al2O3 contents, were deposited on (100) LaAlO3 substrate by pulsed laser deposition (PLD) technique. The Al2O3-BST films was demosnstrated to be a suitable systems to fabricate ferroelectric thin films with low dielectric loss and higher figure of merit for tunable microwave devices. Pure BST thin films were also fabricated for comparison purpose. The films' structure and morphology were analyzed by X-ray diffractiopn and scanning electron microscopy, respectively; nad showed that the surface roughness for the Al2O3-BST films increased with the Al2O3 content. Apart from that, the broadening in the intensity peak in XRD result indicating the grain size of the Al2O3-BST films reduced with the increasing of Al2O3 dopant. We measured the dielctric properties of Al2O3-BST films with a home-made non-destructive dual resonator method at frequency ~ 7.7 GHZ. The effect of doped Al2O3 into BST thin films significantly reduced the dielectric constant, dielectric loss and tunability compare to pure BST thin film. Our result shows the figure of merit (K), used to compare the films with varied dielectric properties, increased with the Al2O3 content. Therefore Al2O3-BST films show the potential to be exploited in tunable microwave devices.Comment: 8 pages, 4 figures, 1 table. Accepted & tentatively for Feb 15 2004 issue, Journal of Applied Physic

E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton's Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants

10.1371/journal.pone.0163035PloS one119e0163035GUSTO (Growing up towards Healthy Outcomes

A single-phase three-level flying-capacitor PFC rectifier without electrolytic capacitors

A component-minimized and low-voltage-stress single-phase power factor correction rectifier without electrolytic capacitor is proposed in this paper. Component minimization is achieved by embedding an active pulsating-power-buffering (PPB) function within each switching period, such that typical add-on power electronic circuits for PPB are no longer needed. Additionally, with a three-level flying-capacitor configuration, the voltage stresses of switching devices can be reduced more than 50% as compared to existing solutions that are based on embedded PPB. The relationship between the inductance requirement and the patterns of the modulation carriers, and how it can be utilized to minimize the magnetics of the rectifier, is also discussed. A 110 W hardware prototype is designed and tested to demonstrate the feasibilities of the proposed rectifier. An input power factor of more than 0.97, peak efficiency of 95.1%, and an output voltage ripple of less than 4.3% across a wide load range have been experimentally obtained.</p

Design Considerations for Voltage Sensorless Control of a PFC Single-Phase Rectifier Without Electrolytic Capacitors

In this paper, a voltage sensorless controller is developed for a two-switch single-phase rectifier that involves power factor correction and active pulsating power buffering without electrolytic capacitors. While a two-switch rectifier normally requires four sensed signals for control, only one current sensor is required in this proposal, thereby offering advantages such as low cost, high compactness, isolation between control and power circuits, and improved reliability. While the basic operating principle follows that of a conventional voltage sensorless controller for single-switch converters, several critical design considerations are the key to the success of the implementation which is explained in detail. The feasibilities of the controller are experimentally testified with a 100-W rectifier prototype regarding both steady state and dynamic performance.</p

Effects of a portion design plate on food group guideline adherence among hospital staff

Food group guideline adherence is vital to prevent obesity and diabetes. Various studies have demonstrated that environmental variables influence food intake behaviour. In the present study we examined the effect of a portion design plate with food group portion guidelines demarcated by coloured lines (ETE Plate™). A two-group quasi-experimental design was used to measure proportions of carbohydrate, vegetable and protein portions and user experience in a hospital staff lounge setting in Singapore. Lunch was served on the portion design plate before 12.15 hours. For comparison, a normal plate (without markings) was used after 12.15 hours. Changes in proportions of food groups from 2 months before the introduction of the design plate were analysed in a stratified sample at baseline (859 subjects, all on normal plates) to 1, 3 and 6 months after (in all 1016 subjects on the design plate, 968 subjects on the control plate). A total of 151 participants were asked about their experiences and opinions. Between-group comparisons were performed using ___t___ tests. Among those served on the portion design plate at 6 months after its introduction, the proportion of vegetables was 4·71 % (P < 0·001) higher and that of carbohydrates 2·83 % (P < 0·001) lower relative to the baseline. No significant change was found for proteins (−1·85 %). Over 6 months, we observed different change patterns between the different food group proportions. While participants were positive about the portion design plate, they did not think it would influence their personal behaviour. A portion design plate might stimulate food group guideline adherence among hospital staff and beyond

Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation

While nonmyeloablative peripheral blood stem cell transplantation (NST) has shown efficacy against several solid tumors, it is untested in nasopharyngeal cancer (NPC). In a phase II clinical trial, 21 patients with pretreated metastatic NPC underwent NST with sibling PBSC allografts, using CY conditioning, thymic irradiation and in vivo T-cell depletion with thymoglobulin. Stable lymphohematopoietic chimerism was achieved in most patients and prophylactic CYA was tapered at a median of day +30. Seven patients (33%) showed partial response and three (14%) achieved stable disease. Four patients were alive at 2 years and three showed prolonged disease control of 344, 525 and 550 days. With a median follow-up of 209 (4–1147) days, the median PFS was 100 days (95% confidence interval (CI), 66–128 days), and median OS was 209 days (95% CI, 128–236 days). Patients with chronic GVHD had better survival—median OS 426 days (95% CI, 194–NE days) vs 143 days (95% CI, 114–226 days) (P=0.010). Thus, NST may induce meaningful clinical responses in patients with advanced NPC