A theorem for the beam splitter entangler

It is conjectured that the an entanglement output states from a beam splitter requires the nonclassicality in the input state(M.S. Kim, W. Son, V. Buzek and P. L. Knight, Phys. Rev. A, 65, 032323(2002)). Here we give a proof for this conjecture.Comment: Two relevant literatures added. To appear in Phys. Rev.

Properties of a beam splitter entangler with Gaussian input states

An explicit formula is given for the quantity of entanglement in the output state of a beam splitter, given the squeezed vacuum states input in each mode.Comment: To appear in Phys. Rev.

Continuous-variable quantum teleportation of entanglement

Entangled coherent states can be used to determine the entanglement fidelity for a device that is designed to teleport coherent states. This entanglement fidelity is universal, in that the calculation is independent of the use of entangled coherent states and applies generally to the teleportation of entanglement using coherent states. The average fidelity is shown to be a poor indicator of the capability of teleporting entanglement; i.e., very high average fidelity for the quantum teleportation apparatus can still result in low entanglement fidelity for one mode of the two-mode entangled coherent state.Comment: 5 pages, 1 figure, published versio

Clinical and Laboratory Associations with Methotrexate Metabolism Gene Polymorphisms in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that causes loss of joint function and significantly reduces quality of life. Plasma metabolite concentrations of disease-modifying anti-rheumatic drugs (DMARDs) can influence treatment efficacy and toxicity. This study explored the relationship between DMARD-metabolising gene variants and plasma metabolite levels in RA patients. DMARD metabolite concentrations were determined by tandem mass-spectrometry in plasma samples from 100 RA patients with actively flaring disease collected at two intervals. Taqman probes were used to discriminate single-nucleotide polymorphism (SNP) genotypes in cohort genomic DNA: rs246240 (ABCC1), rs1476413 (MTHFR), rs2231142 (ABCG2), rs3740065 (ABCC2), rs4149081 (SLCO1B1), rs4846051 (MTHFR), rs10280623 (ABCB1), rs16853826 (ATIC), rs17421511 (MTHFR) and rs717620 (ABCC2). Mean plasma concentrations of methotrexate (MTX) and MTX-7-OH metabolites were higher (p < 0.05) at baseline in rs4149081 GA genotype patients. Patients with rs1476413 SNP TT or CT alleles have significantly higher (p < 0.001) plasma poly-glutamate metabolites at both study time points and correspondingly elevated disease activity scores. Patients with the rs17421511 SNP AA allele reported significantly lower pain scores (p < 0.05) at both study intervals. Genotyping strategies could help prioritise treatments to RA patients most likely to gain clinical benefit whilst minimizing toxicity

Homodyne Bell's inequalities for entangled mesoscopic superpositions

We present a scheme for demonstrating violation of Bell's inequalities using a spin-1/2 system entangled with a pair of classically distinguishable wave packets in a harmonic potential. In the optical domain, such wave packets can be represented by coherent states of a single light mode. The proposed scheme involves standard spin-1/2 projections and measurements of the position and the momentum of the harmonic oscillator system, which for a light mode can be realized by means of homodyne detection. We discuss effects of imperfections, including non-unit efficiency of the homodyne detector, and point out a close link between the visibility of interference and violation of Bell's inequalities in the described scheme.Comment: 6 pages, 3 figures. Extended version, journal reference adde

The effect of grain size on electrical transport and magnetic properties of La0.9Te0.1MnO3

The effect of grain size on structural, magnetic and transport properties in electron-doped manganites La0.9Te0.1MnO3 has been investigated. All samples show a rhombohedral structure with the space group at room temperature. It shows that the Mn-O-Mn bond angle decreases and the Mn-O bond length increases with the increase of grain size. All samples undergo paramagnetic (PM)-ferromagnetic (FM) phase transition and an interesting phenomenon that both magnetization and the Curie temperature decrease with increasing grain size is observed, which is suggested to mainly originate from the increase of the Mn-O bond length . Additionally, obviously increases with decreasing grain size due to the increase of both the height and width of tunneling barriers with decreasing the grain size. The results indicate that both the intrinsic colossal magnetoresistance (CMR) and the extrinsic the extrinsic interfacial magnetoresistance (IMR) can be effectively tuned in La0.9Te0.1MnO3 by changing grain size.Comment: 15 pages,4 figures. Solid state communications 132(2004)83-8

Rising influence of synthetic biology in regenerative medicine

This is an Open Access Article. It is published by IET under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/Synthetic biology is an emerging area of research that combines the investigative nature of biology with the constructive nature of engineering. Despite the field being in its infancy, it has already aided the development of a myriad of industrially and pharmaceutically useful compounds, devices and therapies and is now being applied within the field of regenerative medicine. By combining synthetic biology with regenerative medicine, the engineering of cells and organisms offers potential avenues for applications in tissue engineering, bioprocessing, biomaterial and scaffold development, stem cell therapies and even gene therapies. This review aims to discuss how synthetic biology has been applied within these distinct areas of regenerative medicine, the challenges it faces and any future possibilities this exciting new field may hold

The effect of oxygen stoichiometry on electrical transport and magnetic properties of La0.9Te0.1MnOy

The effect of the variation of oxygen content on structural, magnetic and transport properties in the electron-doped manganites La0.9Te0.1MnOy has been investigated. All samples show a rhombohedral structure with the space group . The Curie temperature decreases and the paramagnetic-ferromagnetic (PM-FM) transition becomes broader with the reduction of oxygen content. The resistivity of the annealed samples increases slightly with a small reduction of oxygen content. Further reduction in the oxygen content, the resistivity maximum increases by six orders of magnitude compared with that of the as-prepared sample, and the r(T) curves of samples with y = 2.86 and y = 2.83 display the semiconducting behavior () in both high-temperature PM phase and low-temperature FM phase, which is considered to be related to the appearance of superexchange ferromagnetism (SFM) and the localization of carriers. The results are discussed in terms of the combined effects of the increase in the Mn2+/(Mn2++Mn3+) ratio, the partial destruction of double exchange (DE) interaction, and the localization of carriers due to the introduction of oxygen vacancies in the Mn-O-Mn network.Comment: 20 pages, 8 figure

Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA

Diagnosing post-transplant lymphoproliferative disorder (PTLD) is challenging and often requires invasive procedures. Analyses of cell-free DNA (cfDNA) isolated from plasma is minimally invasive and highly effective for genomic profiling of tumors. We studied the feasibility of using cfDNA to profile PTLD and explore its potential to serve as a screening tool. We included seventeen patients with monomorphic PTLD after solid organ transplantation in this multi-center observational cohort study. We used low-coverage whole genome sequencing (lcWGS) to detect copy number variations (CNVs) and targeted next-generation sequencing (NGS) to identify Epstein-Barr virus (EBV) DNA load and somatic single nucleotide variants (SNVs) in cfDNA from plasma. Seven out of seventeen (41%) patients had EBV-positive tumors, and 13/17 (76%) had stage IV disease. Nine out of seventeen (56%) patients showed CNVs in cfDNA, with more CNVs in EBV-negative cases. Recurrent gains were detected for 3q, 11q, and 18q. Recurrent losses were observed at 6q. The fraction of EBV reads in cfDNA from EBV-positive patients was 3-log higher compared to controls and EBV-negative patients. 289 SNVs were identified, with a median of 19 per sample. SNV burden correlated significantly with lactate dehydrogenase levels. Similar SNV burdens were observed in EBV-negative and EBV-positive PTLD. The most commonly mutated genes were TP53 and KMT2D (41%), followed by SPEN, TET2 (35%), and ARID1A, IGLL5, and PIM1 (29%), indicating DNA damage response, epigenetic regulation, and B-cell signaling/NFkB pathways as drivers of PTLD. Overall, CNVs were more prevalent in EBV-negative lymphoma, while no difference was observed in the number of SNVs. Our data indicated the potential of analyzing cfDNA as a tool for PTLD screening and response monitoring.</p