Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.

The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction. To understand the nature of the interaction between Ti and CD3, chimeric molecules which included the COOH-terminal segments of Ti alpha or beta linked to the extracellular segment of CD8, were transfected into a mutant T cell deficient in Ti beta chain expression and cell surface CD3. Both chimeric chains were required to express the chimeric Ti and to restore CD3 surface expression. CD8/Ti and CD3 cointernalized and coimmunoprecipitated. Stimulation of the chimeric receptor induced transmembrane signaling events and cell activation. These results demonstrate that the Ti alpha and beta COOH termini containing the transmembrane domains are sufficient for structural and functional coupling of Ti to CD3

Grappling with Issues of Learning Science from Everyday Experiences: An Illustrative Case Study

There are different perceptions among researchers with regard to the infusion of everyday experience in the teaching of science: 1) it hinders the learning of science concepts; or, 2) it increases the participation and motivation of students in science learning. This article attempts to contemplate those different perspectives of everyday knowledge in science classrooms by using everyday contexts to teach grade 3 science in Singapore. In this study, two groups of grade 3 students were presented with a scenario that required them to apply the concept of properties of materials to design a shoe. Subsequently, the transcripts of classroom discussions and interactions were analyzed using the framework of sociocultural learning and an interpretative analytic lens. Our analysis suggests that providing an authentic everyday context is insufficient to move young learners of science from their everyday knowledge to scientific knowledge. Further, group interactions among young learners of science to solve an everyday issue need to be scaffolded to ensure meaningful, focused, and sustained learning. Implications for research in science learning among younger students are discussed

Non-equilibrium spatial distribution of Rashba spin torque in ferromagnetic metal layer

We study the spatial distribution of spin torque induced by a strong Rashba spin-orbit coupling (RSOC) in a ferromagnetic (FM) metal layer, using the Keldysh non-equilibrium Green's function method. In the presence of the s-d interaction between the non-equilibrium conduction electrons and the local magnetic moments, the RSOC effect induces a torque on the moments, which we term as the Rashba spin torque. A correlation between the Rashba spin torque and the spatial spin current is presented in this work, clearly mapping the spatial distribution of Rashba Spin torque in a nano-sized ferromagnetic device. When local magnetism is turned on, the out-of-plane (Sz) Spin Hall effect (SHE) is disrupted, but rather unexpectedly an in-plane (Sy) SHE is detected. We also study the effect of Rashba strength (\alpha_R) and splitting exchange (\Delta) on the non-equilibrium Rashba spin torque averaged over the device. Rashba spin torque allows an efficient transfer of spin momentum such that a typical switching field of 20 mT can be attained with a low current density of less than 10^6 A/cm^2

Electron and trap dynamics in As-ion-implanted and annealed GaAs

The ultrafast dynamics of As-ion-implanted and annealed GaAs is investigated using transmission pump–probe measurements.Carrier recombination time was found to increase from 4 to 40 ps with increasing annealing temperature. At lower annealing temperatures, the transmitted optical signal is dominated by induced absorption and at higher annealing temperatures this effect is replaced by induced transparency.This work was supported in part by the EC INCOCOPERNICUS project ‘‘DUO—devices for ultrafast optoelectronics’’ and the Lithuanian Science and Study Foundation

Learning circuits with few negations

Monotone Boolean functions, and the monotone Boolean circuits that compute them, have been intensively studied in complexity theory. In this paper we study the structure of Boolean functions in terms of the minimum number of negations in any circuit computing them, a complexity measure that interpolates between monotone functions and the class of all functions. We study this generalization of monotonicity from the vantage point of learning theory, giving near-matching upper and lower bounds on the uniform-distribution learnability of circuits in terms of the number of negations they contain. Our upper bounds are based on a new structural characterization of negation-limited circuits that extends a classical result of A. A. Markov. Our lower bounds, which employ Fourier-analytic tools from hardness amplification, give new results even for circuits with no negations (i.e. monotone functions)

Clostridium difficile colitis in patients after kidney and pancreas-kidney transplantation

Limited data exist about Clostridium difficile colitis (CDC) in solid organ transplant patients. Between 1/1/99 and 12/31/02, 600 kidney and 102 pancreas–kidney allograft recipients were transplanted. Thirty-nine (5.5%) of these patients had CDC on the basis of clinical and laboratory findings. Of these 39 patients, 35 have information available for review. CDC developed at a median of 30 days after transplantation, and the patients undergoing pancreas–kidney transplantation had a slightly higher incidence of CDC than recipients of kidney alone (7.8% vs. 4.5%, P> 0.05). All but one patient presented with diarrhea. Twenty-four patients (64.9%) were diagnosed in the hospital, and CDC occurred during first hospitalization in 14 patients (40%). Treatment was with oral metronidazole (M) in 33 patients (94%)and M + oral vancomycin (M + V) in 2 patients. Eight patients had recurrent CDC, which occurred at a median of 30 days (range 15–314) after the first episode. Two patients (5.7%) developed fulminant CDC, presented with toxic megacolon, and underwent colectomy. One of them died; the other patient survived after colectomy. CDC should be considered as a diagnosis in transplant patients with history of diarrhea after antibiotic use, and should be treated aggressively before the infection becomes complicated

Kinetic description of hadron-hadron collisions

A transport model based on the mean free path approach to describe pp collisions is proposed. We assume that hadrons can be treated as bags of partons similarly to the MIT bag model. When the energy density in the collision is higher than a critical value, the bags break and partons are liberated. The partons expand and can make coalescence to form new hadrons. The results obtained compare very well with available data and some prediction for higher energies collisions are discussed. Based on the model we suggest that a QGP could already be formed in the pp collisions at high energies