EXPERIMENTAL STUDIES IN INTESTINAL HEALING OF THE DOG : II OBSERVATION ON END-TO-END SMALL INTESTINAL ANASTOMOSIS

Wound healing of end-to-end small intestinal anastomosis was studied and compared with previously reported data on side-to-side small intestinal anastomotic wound. The healing process of end-to-end anastomosis was basically similar to that of side-to-side anastomosis. However, an increase in vascularity at the anastomotic site is less severe and mucosal regeneration on the defect is more delayed in end-to-end anastomosis than those in side-to-side anastomosis

TRANSPLANTATION OF CANINE TRANSMISSIBLE VENEREAL SARCOMA : AUTORADIOGRAPHIC STUDY WITH ^3H-THYMIDINE

Canine transmissible venereal sarcoma, maintained from puppy to puppy since 1967,was labeled with ^3H-thymidine and transplanted by subcutaneous injection in the hypogastric regions of two puppies. It was observed that the newly formed tumors were canine transmissible venereal sarcoma and that the tumor cells contained ^3H-thymidine. It was proved that the new tumors were caused by multiplication of the transplanted tumor cells

CLINICAL CASES OF INTESTINAL OBSTRUCTION WITH FOREIGN BODIES AND INTUSSUSCEPTION IN DOGS

The medical records of dogs treated in our veterinary hospital during a period of 15 years until 1978 were reviewed. Intestinal obstruction was diagnosed in 47 dogs, among which 51.06% were under 12 months of age and 80.85% were under 3 years. The period which elasped from the appearance of clinical signs to the operation of the obstructed intestines averaged about 5 days (ranging from 1 to 24 days). The presurgical hematological findings of 5 dogs with intestinal obstruction suggested hemoconcentration, low level chloride in the serum, and a rise in the whole blood pH. In the cases of intestinal obstruction in dogs, 87.23% were caused by foreign bodies and 12.77% with intussusceptions. The foreign bodies were stones (41.46%), corn-cobs (24.39%), and others. The cranial portions of the obstructing intestines were dilated 1.4 to 1.8 times as much as the caudal portions, and the intestines of the obstructing sites were 1.7 to 2.7 times larger than the caudal portions. The severely damaged intestines were excised partially from 2 patients and incised only from 45 patients. Three patients died during and after the intestinal operation, but 44 patients recovered to normal following surgery. Biopsy specimens of the caudal intestines of the obstructing sites revealed normal tissues, but the microscopical examinations showed epithelial desquamation, hyperaemic and hemorrhages in the lamina propria, and edema and hemorrhages in the muscle

Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla

Objectives: To investigate whether subendocardial and transmural myocardial infarction can be identified and differentiated using the peak circumferential and longitudinal strains measured by fast strain-encoded (SENC). Methods: Nineteen patients with ischemic heart diseases underwent imaging with fast SENC and late gadolinium enhancement (LGE) MRI at 3T. Fast SENC measurements were performed in three short-axis slices (basal, mid-ventricular and apical levels) and one long-axis view (four-chamber) to assess peak longitudinal and circumferential systolic strains. Results: All patients showed myocardial infarction with an average of 7 positive LGE segments. A total of 304 segments for longitudinal strains (LS) and 114 segments for circumferential strains (CS) could be analysed. Positive LGE segments showed lower peak CS and LS compared with the no-LGE segments (P < 0.0001 for both). Segments with subendocardial infarction showed reduced CS and LS compared with the no-LGE segments (P < 0.0001 for both). There was a significant difference in CS between subendocardial and transmural infarct segments (P = 0.03), but no significant difference in LS between them (P = 0.64). Conclusions: Fast SENC can identify old myocardial infarction and differentiate subendocardial from transmural infarction

Diaphragm dome height on chest radiography as a predictor of dynamic lung hyperinflation in COPD

Background and objective Dynamic lung hyperinflation (DLH) can play a central role in exertional dyspnoea in patients with COPD. Chest radiography is the basic tool for assessing static lung hyperinflation in COPD. However, the predictive capacity of DLH using chest radiography remains unknown. This study was conducted to determine whether DLH can be predicted by measuring the height of the right diaphragm (dome height) on chest radiography. Methods This single-centre, retrospective cohort study included patients with stable COPD with pulmonary function test, cardiopulmonary exercise test, constant load test and pulmonary images. They were divided into two groups according to the median of changes of inspiratory capacity (ΔIC=IC lowest − IC at rest). The right diaphragm dome height and lung height were measured on plain chest radiography. Results Of the 48 patients included, 24 were classified as having higher DLH (ΔIC ≤−0.59 L from rest; −0.59 L, median of all) and 24 as having lower DLH. Dome height correlated with ΔIC (r=0.66, p<0.001). Multivariate analysis revealed that dome height was associated with higher DLH independent of % low attenuation area on chest computed tomography and forced expiratory volume in 1 s (FEV1) % predicted. Furthermore, the area under the receiver operating characteristic curve of dome height to predict higher DLH was 0.86, with sensitivity and specificity of 83% and 75%, respectively, at a cut-off of 20.5 mm. Lung height was unrelated to ΔIC. Conclusion Diaphragm dome height on chest radiography may adequately predict higher DLH in patients with COPD