Wound healing of end-to-end small intestinal anastomosis was studied and compared with previously reported data on side-to-side small intestinal anastomotic wound. The healing process of end-to-end anastomosis was basically similar to that of side-to-side anastomosis. However, an increase in vascularity at the anastomotic site is less severe and mucosal regeneration on the defect is more delayed in end-to-end anastomosis than those in side-to-side anastomosis