市販おにぎりの細菌汚染および保存による細菌の挙動

Recently rice balls with various stuffing are seen sold in many places like convenience stores and delicatessen. We surveyed bacterial contamination in them mainly mixed with marine food. Research was made on bacterial action after purchase to expiry date, and also on how they react to an added Escherichia coli, in particular when the preserving condition is worse. The level of general bacteria, coliforms and Staphylococcus aureus in rice balls are kept at 10^5CFU/g, but some expired rice balls indicate over 10^7CFU/g. Also, some rice balls showed increased bacteria over 10^7CFU/g, when E.coli is added and it is left at room temperature. Therefore, rice ball products need to be eaten soon after purchase and there is need to be cautious about the temperature of its preservation

Prognostic impact of clinical factors for immune checkpoint inhibitor with or without chemotherapy in older patients with non-small cell lung cancer and PD-L1 TPS ≥ 50%

IntroductionThe proportion of older patients diagnosed with advanced-stage non-small cell lung cancer (NSCLC) has been increasing. Immune checkpoint inhibitor (ICI) monotherapy (MONO) and combination therapy of ICI and chemotherapy (COMBO) are standard treatments for patients with NSCLC and programmed cell death ligand-1 (PD-L1) tumor proportion scores (TPS) ≥ 50%. However, evidence from the clinical trials specifically for older patients is limited. Thus, it is unclear which older patients benefit more from COMBO than MONO.MethodsWe retrospectively analyzed 199 older NSCLC patients of Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 and PD-L1 TPS ≥ 50% who were treated with MONO or COMBO. We analyzed the association between treatment outcomes and baseline patient characteristics in each group, using propensity score matching.ResultsOf the 199 patients, 131 received MONO, and 68 received COMBO. The median overall survival (OS; MONO: 25.2 vs. COMBO: 42.2 months, P = 0.116) and median progression-free survival (PFS; 10.9 vs. 11.8 months, P = 0.231) did not significantly differ between MONO and COMBO group. In the MONO group, OS was significantly shorter in patients without smoking history compared to those with smoking history [HR for smoking history against non-smoking history: 0.36 (95% CI: 0.16-0.78), P = 0.010]. In the COMBO group, OS was significantly shorter in patients with PS 1 than those with PS 0 [HR for PS 0 against PS 1: 3.84 (95% CI: 1.44-10.20), P = 0.007] and for patients with squamous cell carcinoma (SQ) compared to non-squamous cell carcinoma (non-SQ) [HR for SQ against non-SQ: 0.17 (95% CI: 0.06-0.44), P < 0.001]. For patients with ECOG PS 0 (OS: 26.1 months vs. not reached, P = 0.0031, PFS: 6.5 vs. 21.7 months, P = 0.0436) or non-SQ (OS: 23.8 months vs. not reached, P = 0.0038, PFS: 10.9 vs. 17.3 months, P = 0.0383), PFS and OS were significantly longer in the COMBO group.ConclusionsECOG PS and histological type should be considered when choosing MONO or COMBO treatment in older patients with NSCLC and PD-L1 TPS ≥ 50%

ゾル-ゲル法による多孔質シりカ担体への酵母の固定化

The porous silica gels were prepared from tetramethoxysilane (TMOS)-polyethyleneglycol (PEG)-H_2O-methanol solution by the sol-gel process. Microstructure of gel was affected by the composition of starting solutions. The pore diameter of porous gels ranged from 0.1μm to 10μn. The pore diameter increased with increasing H_2O and H_2SO_4 contents and with increasing molecular weight of PEG, whilst it decreased with increasing PEG concentration. Yeast cells were immobilized in porous silica gels prepared from TMOS-PEG solutions by the sol-gel process. Yeast cells were immobilized as spores. After incubation, yeast spores germed and growth of the yeasts were comfirmed

Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report

A 58-year-old woman with lung cancer complaint odynophagia by sour food. Endoscopic examination revealed severe erosion strictly limited to the esophagus. Drug-induced esophagitis was suspected. She was taking afatinib, loxoprofen, pregabalin, lorazepam, a formulation of butyric acid bacteria, and amino acid supplements for more than 1 month at the time of developing esophagitis. Her appetite was very poor for several days before developing the esophagitis. Although not definitive, the most probable cause of her esophagitis is an increased blood concentration of afatinib due to prolonged starved condition

多孔質ガラス担体に固定化した水銀還元酵素の作製及びその特性

The immobilized mercuric reductase covalently coupled to porous glass was prepared and its properties were investigated. Mercuric reductase immobilized on arylamino and carboxyl derivatives exhibited high relative activities about 20-30% compared with soluble enzymes. The optimum pH of mercuric reductase immobilized on these derivatives was 7.5, slightly higher than that of soluble state (7.0-7.2). The stability of mercuric reductase increased with immobilization onto arylamino derivative and the immobilized enzyme maintained at 30℃ for 29 days showed 80-90% of initial activity. As the application of immobilized enzyme, mercuric ion sensor was prepared and it was found that mercuric ion higher than 0.5μM was detectable with this sensor

Design, Implementation, and Evaluation of Optimizations in a Just-In-Time Compiler

The Java language incurs a runtime overhead for exception checks and object accesses without an interior pointer in order to ensure safety. It also requires type inclusion test, dynamic class loading, and dynamic method calls in order to ensure flexibility. A "JustIn -Time" (JIT) compiler generates native code from Java byte code at runtime. It must improve the runtime performance without compromising the safety and flexibility of the Java language. We designed and implemented effective optimizations for the JIT compiler, such as exception check elimination, common subexpression elimination, simple type inclusion test, method inlining, and resolution of dynamic method call. We evaluate the performance benefits of these optimizations based on various statistics collected using SPECjvm98 and two JavaSoft applications with byte code sizes ranging from 20000 to 280000 bytes. Each optimization contributes to an improvement in the performance of the programs. 1. Introduction Java [1] is a ..

Successful osimertinib rechallenge after osimertinib-induced pneumonitis in a patient with lung adenocarcinoma

Pneumonitis is a serious adverse event of EGFR-TKI treatment. Although several cases of EGFR-TKI rechallenge after EGFR-TKI-induced pneumonitis have been reported, little is known about post-pneumonitis osimertinib rechallenge. We describe a 69-year-old never-smoking Japanese woman with postoperative recurrent lung adenocarcinoma retreated with osimertinib after osimertinib-induced pneumonitis. Although osimertinib rechallenge must be carefully chosen based on risk/benefit analysis, osimertinib rechallenge after osimertinib-induced pneumonitis may be an option, with limited alternative therapeutic options. Keywords: Osimertinib, Pneumonitis, Rechallenge, Corticosteroi

Design, Implementation, and Evaluation of Optimizations in a Java ™ Just-In-Time Compiler

The Java language incurs a runtime overhead for exception checks and object accesses, which are executed without an interior pointer in order to ensure safety. It also requires type inclusion test, dynamic class loading, and dynamic method calls in order to ensure flexibility. A “Just-In-Time ” (JIT) compiler generates native code from Java byte code at runtime. It must improve the run-time performance without compromising the safety and flexibility of the Java language. We designed and implemented effective optimizations for a JIT compiler, such as exception check elimination, common subexpression elimination, simple type inclusion test, method inlining, and devirtualization of dynamic method call. We evaluate the performance benefits of these optimizations based on various statistics collected using SPECjvm98, its candidates, and two JavaSoft applications with byte code sizes ranging from 23000 to 280000 bytes. Each optimization contributes to an improvement in the performance of the programs. 1