46 research outputs found
The Direct Acyl-Alkylation of Arynes
An efficient and mild acyl-alkylation of arynes is described. The method is used to synthesize medium-sized carbocycles by the ring-expansion of cyclic 尾-ketoesters
Los fantasmas en el teatro de Itziar Pascual : memoria y construcci贸n identitaria
Este ensayo ofrece un an谩lisis de los personajes fantasmales y las sombras que aparecen en varias obras de Itziar Pascual (Fuga, El domador de sombras, Blue Mountain, La paz del crep煤sculo, P猫re Lachaise, Despedida, Mascando ortigas y Variaciones sobre Rosa Parks), en las que se observa la estrecha relaci贸n que guarda la introducci贸n de espectros con la reivindicaci贸n de la memoria y la indagaci贸n en la identidad tanto individual como colectiva.This essay offers an analysis of the phantoms that appear in several plays by Itziar Pascual (Fuga, El domador de sombras, Blue Mountain, La paz del crep煤sculo, P猫re Lachaise, Despedida, Mascando ortigas y Variaciones sobre Rosa Parks). There is a relationship between the presence of these spectral characters in theatre, the recovery of memory and the construction of personal and collective identity
Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction
A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems
A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C鈭扝 and C鈭扖 Bond Insertion Reactions
A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C鈭扝 and C鈭扖 bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories
Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: Applications to the total synthesis of alkaloids
Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in diverse contexts and the ability of this methodology to set the absolute configuration of multiple stereocenters in a single operation. The utility of an aryne C-C insertion reaction in accessing complex polycyclic frameworks is also described
Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction
A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems
Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/polyaneuploid giant cancer cells (PGCCs/PACCs) that resist antimitotic drugs
View full abstracthttps://openworks.mdanderson.org/leading-edge/1044/thumbnail.jp
A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C鈭扝 and C鈭扖 Bond Insertion Reactions
A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C鈭扝 and C鈭扖 bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories