The Direct Acyl-Alkylation of Arynes

An efficient and mild acyl-alkylation of arynes is described. The method is used to synthesize medium-sized carbocycles by the ring-expansion of cyclic β-ketoesters

Los fantasmas en el teatro de Itziar Pascual : memoria y construcción identitaria

Este ensayo ofrece un análisis de los personajes fantasmales y las sombras que aparecen en varias obras de Itziar Pascual (Fuga, El domador de sombras, Blue Mountain, La paz del crepúsculo, Père Lachaise, Despedida, Mascando ortigas y Variaciones sobre Rosa Parks), en las que se observa la estrecha relación que guarda la introducción de espectros con la reivindicación de la memoria y la indagación en la identidad tanto individual como colectiva.This essay offers an analysis of the phantoms that appear in several plays by Itziar Pascual (Fuga, El domador de sombras, Blue Mountain, La paz del crepúsculo, Père Lachaise, Despedida, Mascando ortigas y Variaciones sobre Rosa Parks). There is a relationship between the presence of these spectral characters in theatre, the recovery of memory and the construction of personal and collective identity

Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction

A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems

A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C−H and C−C Bond Insertion Reactions

A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C−H and C−C bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories

Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: Applications to the total synthesis of alkaloids

Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in diverse contexts and the ability of this methodology to set the absolute configuration of multiple stereocenters in a single operation. The utility of an aryne C-C insertion reaction in accessing complex polycyclic frameworks is also described

Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction

A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems

Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/polyaneuploid giant cancer cells (PGCCs/PACCs) that resist antimitotic drugs

View full abstracthttps://openworks.mdanderson.org/leading-edge/1044/thumbnail.jp

The direct acyl-alkylation of arynes. Preparation of methyl 2-(2-acetylphenyl)acetate

[no abstract

A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C−H and C−C Bond Insertion Reactions

A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C−H and C−C bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories